Waukulu >> Maphunziro A Zaumoyo >> Metformin vs. metformin ER: Kusiyana, kufanana, ndi zomwe zili zabwino kwa inu

Metformin vs. metformin ER: Kusiyana, kufanana, ndi zomwe zili zabwino kwa inu

Maphunziro a Zaumoyo

Metformin ndi mankhwala omwe amadziwika kuti amagwiritsidwa ntchito pochiza mtundu wachiwiri wa matenda ashuga. Ndiwo antidiabetic wothandizila omwe ali mgulu la mankhwala omwe amadziwika kuti biguanides. Zimagwira ntchito pochepetsa shuga (shuga wamagazi) kupanga chiwindi, kuchepa kwa shuga m'matumbo, komanso kuwonjezera chidwi cha insulin. Metformin imapangitsa kuti insulini imvetse bwino poonjezera kuchuluka kwa shuga m'magulu a thupi.

Mtundu wachiwiri wa shuga umapezeka thupi likagonjetsedwa ndi insulin. Insulini ndi mahomoni ofunikira omwe amapangidwa ndi kapamba ndipo amagwiritsidwa ntchito kunyamula shuga m'maselo amthupi kuti akhale ndi mphamvu. Thupi likalephera kugwiritsa ntchito insulini moyenera, kuchuluka kwa shuga m'magazi kumawuka komwe kumatha kuwononga mitsempha ndi mitsempha. Popanda chithandizo choyenera, matenda ashuga amatha kuyambitsa zovuta ndi kuwonongeka kwa ziwalo monga mtima ndi impso.

Metformin imapezeka mu fomu yotulutsira pomwepo (IR) ndi fomu yotulutsa-kutulutsa (ER). Ngakhale mitundu yonse ya metformin ili ndi zinthu zomwezo, zimatengedwa m'njira zosiyanasiyana. Amakhalanso ndi zovuta zina.

Kodi pali kusiyana kotani pakati pa metformin ndi metformin ER?

Metformin kapena metformin hydrochloride ndi dzina lodziwika bwino la Glucophage. Kutulutsa msanga metformin nthawi zambiri kumayikidwa ngati piritsi la 500 mg lomwe limatengedwa kawiri tsiku lililonse ndi chakudya. Palinso piritsi la 850 mg lomwe limatha kumwedwa kamodzi tsiku lililonse. Mlingo waukulu wa metformin ndi 2550 mg patsiku m'magawo ogawanika. Metformin imatha kuthana ndi matenda ashuga amtundu wa 2 mwa akulu komanso ana.

Metformin ER imadziwikanso ndi dzina loti Glucophage XR. Ndiwo mtundu wa metformin womasulidwa ndipo umangofunika kumwedwa kamodzi tsiku ndi tsiku ndi chakudya. Mlingo wokwanira wa tsiku ndi tsiku wa metformin ER ndi 2000 mg. Mosiyana ndi metformin yotulutsidwa mwachangu, metformin ER imangowonetsedwa kwa akulu omwe ali ndi matenda amtundu wa 2. Ilinso ndi zovuta zoyipa zochepa ndipo imatenga nthawi yayitali kuposa metformin yanthawi zonse.

YAM'MBUYO YOTSATIRA: Zambiri za Metformin | Zambiri za Metformin ER

Kusiyana kwakukulu pakati pa metformin ndi metformin ER
	Metformin	Metformin ER
Gulu la mankhwala osokoneza bongo	Zamgululi	Zamgululi
Chizindikiro cha Brand / generic	Mtundu wa generic ulipo	Mtundu wa generic ulipo
Kodi dzina lake ndi ndani?	Glucophage	Glucophage XR, Fortamet, Glumetza
Kodi mankhwalawa amabwera mwa mawonekedwe ati?	Piritsi lapakamwa	Piritsi lapakamwa, kutulutsa kwina
Kodi mulingo woyenera ndi uti?	500 mg kawiri tsiku lililonse kapena 850 mg kamodzi tsiku lililonse ndi chakudya	500 mg kamodzi tsiku lililonse ndi chakudya chamadzulo
Kodi mankhwalawa amatenga nthawi yayitali bwanji?	Kutalika kwakanthawi koyang'anira matenda ashuga	Kutalika kwakanthawi koyang'anira matenda ashuga
Ndani amagwiritsa ntchito mankhwalawa?	Akuluakulu ndi ana azaka 10 kapena kupitilira apo	Akuluakulu

Zomwe zimathandizidwa ndi metformin ndi metformin ER

Onse metformin ndi metformin ER ndi ovomerezeka ndi FDA kuti athetse mtundu wa 2 wa matenda ashuga. Malinga ndi Bungwe la American Diabetes Association (ADA) , metformin ndi mankhwala oyamba amtundu wa 2 matenda ashuga. Odwala omwe ali ndi A1c ochepera 9% panthawi yakuzindikira, metformin iyenera kuyambitsidwa ngati monotherapy pa Miyezo Yachipatala mu Matenda A shuga . Metformin itha kuthandizira kuwongolera glycemic control ndipo pamapeto pake kupewa zovuta zomwe zingayambike chifukwa cha matenda ashuga.

Sikuti metformin itha kugwiritsidwa ntchito pochiza mtundu wachiwiri wa matenda ashuga, itha kugwiritsidwanso ntchito pazosalemba. Omwe ali ndi matenda ashuga komanso kusala kudya kwa plasma (FPG) kungalimbikitsidwe metformin popewa kuyambika kwa matenda ashuga. Metformin imalimbikitsidwa ngati magawo ashuga yamagazi samayendetsedwa ndi zakudya komanso masewera olimbitsa thupi okha.

Metformin itha kugwiritsidwanso ntchito ngati njira yolembapo zochizira matenda ashuga. Matenda a shuga amtunduwu amapezeka mwa amayi apakati omwe amakonda kukhala ndi matenda ashuga. Komabe, insulin amayesedwa koyambirira.

Metformin yakhalanso anaphunzira kuchiza matenda a polycystic ovary (POCS). Matendawa amadziwika ndi kuchepa kwa mahomoni ogonana omwe angayambitse zotupa zam'mimba, kusintha kwa msambo, zovuta zapakati, ziphuphu, komanso kukana kwa insulin. Metformin itha kulamulidwa kuti ichepetse kukana kwa insulin, kuchepetsa kuchuluka kwa testosterone, komanso kusintha kusamba komanso kubereka.

Kugwiritsa ntchito mankhwala a antipsychotic, monga olanzapine, risperidone, ndi clozapine, kumatha kubweretsa kunenepa. Malinga ndi kafukufuku wina, Metformin yawonetsedwa kuti ndi othandiza pochizira kunenepa komwe kumapangitsa kuti munthu akhale wonenepa. Ndemanga imodzi idapeza kuti metformin idathandizira kuchepetsa kuchuluka kwa mthupi (BMI), kulemera kwa thupi, komanso kukana kwa insulin poyerekeza ndi placebo mwa iwo omwe ali ndi antipsychotic-induced weight.

Mkhalidwe	Metformin	Metformin ER
Type 2 kasamalidwe ka matenda ashuga	Inde	Inde
Type 2 kupewa kwa matenda ashuga	Kutumiza	Kutumiza
Gestational matenda a shuga	Kutumiza	Kutumiza
Matenda a Polycystic ovary	Kutumiza	Kutumiza
Kulemera chifukwa cha mankhwala a antipsychotic	Kutumiza	Kutumiza

Kodi metformin kapena metformin ER ndi yothandiza kwambiri?

Kutengera kafukufuku woyerekeza metformin ndi metformin ER yamtundu wa 2 shuga, metformin ER yapezeka kuti ikufanana ndi metformin moyenera. M'malo mwake, metformin ER itha kukhala yopambana kuposa metformin yokhazikika potengera zotsatira zake zoyipa komanso kugwiritsa ntchito mosavuta. Omwe ali ndi matenda a shuga amtundu wa 2 amatha kukhala ndi chizolowezi chomwa mapiritsi a metformin kamodzi patsiku m'malo mwa mapiritsi a tsiku ndi tsiku.

Mmodzi mwachisawawa, maphunziro azachipatala , metformin ER yapezeka kuti imagwira ntchito bwino kuposa metformin IR pochiza odwala matenda ashuga amtundu wa 2. Omwe amatenga metformin ER adakumana ndi vuto loyendetsa glycemic komanso lipid metabolism poyerekeza ndi metformin IR.

China china chosasintha, kuyesedwa kosawona anapeza kuti metformin ER kamodzi patsiku inali ndi mphamvu zofananira komanso chitetezo ku metformin wamba. Kuphatikiza apo, kafukufukuyu adapeza mwayi wokhala ndi dosing kamodzi patsiku ndi metformin ER. Metformin ndi metformin ER onse adakulitsa milingo ya HbA1c pamasabata a 24 pamitu yomwe sinayeserepo chithandizo china chilichonse cha matenda awo ashuga.

Kutulutsa kotulutsa metformin kumakondedwa m'malo mongotulutsa metformin. Zawonetsedwa kuti zili ndi kulolerana kwabwino ngakhale zitha kukhala zodula kuposa mapiritsi omwe amatulutsidwa mwachangu. Ndikofunika kufunsa upangiri wa zamankhwala kuchokera kwa akatswiri azaumoyo posankha njira yothandizila mtundu wachiwiri wa matenda ashuga.

Kuphunzira ndi kuyerekezera mtengo wa metformin vs. metformin ER

Metformin ndi mtundu wa Glucophage. Generic metformin imaphimbidwa ndi Medicare gawo D komanso mapulani ambiri a inshuwaransi. Glucophage wodziwika ndi dzina lake akhoza kukhala wotsika mtengo kwambiri ndipo amawononga mtengo wogulitsa wopitilira $ 150. Mtengo uwu ukhoza kuchepetsedwa pobweretsa khadi yotsitsa ya SingleCare ku pharmacy. Khadi la metformin SingleCare limatha kubweretsa mtengo mpaka $ 4 pamasiku 30 a metformin yotulutsidwa mwachangu.

Pafupifupi onse Medicare ndi mapulani a inshuwaransi azigwiritsa ntchito generic metformin ER. Glucophage XR yotchedwa Brand imatha kukhala pafupifupi $ 80 kutengera mankhwala omwe mukupitako. Ndi khadi ya Coupon ya SingleCare, generic metformin ER itha kugulidwa pamtengo wotsika mpaka $ 4 pamasiku 30 a mapiritsi a metformin ER kamodzi patsiku. Ngakhale ndi inshuwaransi, SingleCare imatha kupereka mtengo wotsika. Funsani ku pharmacy yanu kuti muwone ngati mungagwiritse ntchito mwayi wotsatsa ndi SingleCare.

Pezani khadi yotsitsa ya SingleCare

	Metformin	Metformin ER
Nthawi zambiri amakhala ndi inshuwaransi?	Inde	Inde
Nthawi zambiri amadzazidwa ndi Medicare?	Inde	Inde
Mlingo woyenera	Mapiritsi 500 mg (kuchuluka kwa mapiritsi 60)	Mapiritsi 500 mg (kuchuluka kwa mapiritsi 30)
Wopanga Medicare wamba	$ 0- $ 8	$ 0- $ 8
Mtengo wosakwatiwa	$ 4	$ 4

Zotsatira zoyipa za metformin vs. metformin ER

Metformin imayambitsa zovuta zomwe zimakhudza dongosolo la m'mimba (GI). Izi zotsatira zoyipa Phatikizani kutsekula m'mimba, mseru, kusanza, mpweya (flatulence), kudzimbidwa, kusapeza m'mimba kapena kukhumudwa m'mimba. Metformin IR imayambitsanso kutopa kapena kusowa mphamvu (asthenia) komanso kupweteka mutu.

Metformin ER ili ndi zovuta zochepa poyerekeza ndi metformin. Zotsatira zoyipa zomwe zimakhudzana ndi metformin ER ndi kutsegula m'mimba, mseru, ndi kusanza. Metformin ER ingayambitsenso kudzimbidwa mwa anthu ena. Ngakhale metformin ER imatha kuyambitsa zovuta zina za GI monga kudzimbidwa ndi kupunduka, zotsatirazi sizimachitika kawirikawiri poyerekeza ndi metformin wamba.

Zotsatira zina zoyipa zomwe zimatha kuchitika ndi metformin ndi metformin ER ndi chizungulire, kupepuka mutu, komanso kusokonezeka kwa kukoma. Zotsatira zina zoyipa kwambiri za metformin ndi metformin ER zimaphatikizapo kuvulala kwa chiwindi ndi hypoglycemia (shuga wotsika magazi).

	Metformin	Metformin ER
Zotsatira zoyipa	Zoyenera?	Pafupipafupi	Zoyenera?	Pafupipafupi
Kutsekula m'mimba	Inde	53%	Inde	10%
Nseru kapena kusanza	Inde	26%	Inde	7%
Kudzikweza	Inde	12%	Inde	1% -5%
Asthenia	Inde	9%	Ayi	-
Kudzimbidwa	Inde	7%	Inde	1% -5%
Kukhumudwa m'mimba	Inde	6%	Inde	1% -5%
Mutu	Inde	6%	Inde	1% -5%
Kudzimbidwa	Ayi	-	Inde	1% -5%
Lawani chisokonezo	Inde	1% -5%	Inde	1% -5%
Chizungulire / mutu wopepuka	Inde	1% -5%	Inde	1% -5%

Uwu sungakhale mndandanda wathunthu. Funsani dokotala wanu kapena wamankhwala pazotsatira zomwe zingachitike.
Gwero: DailyMed ( Metformin ), Tsiku Lililonse ( Metformin ER )

Kuyanjana kwa mankhwala a metformin vs. metformin ER

Metformin ndi metformin ER amatha kulumikizana ndi mankhwala osiyanasiyana. Kuyanjana kwa mankhwala nthawi zambiri kumabweretsa kusintha kwa magazi m'magazi, chiopsezo chowonjezeka cha lactic acidosis , kapena kudzikundikira kwa metformin m'magazi komwe kumatha kuonjezera ngozi yoyipa.

Kutenga metformin ndi mankhwala otchedwa carbonic anhydrase inhibitors kumatha kuonjezera chiopsezo cha lactic acidosis, chiwopsezo chowopsa kuchokera ku lactate wambiri m'thupi. Mankhwalawa amaphatikizapo topiramate ndi acetazolamide pakati pa ena.

Mankhwala monga dolutegravir, cimetidine, ndi ranolazine amatha kuchepetsa chilolezo cha metformin. Izi zitha kubweretsa kuchuluka kwa metformin m'magazi ndikuwonjezera chiopsezo cha zovuta.

Mankhwala ena monga okodzetsa, corticosteroids, phenothiazines, estrogens, njira zakulera zam'kamwa, komanso zotchingira calcium njira zimatha kusokoneza kuwongolera kwa shuga. Kumwa mankhwala aliwonsewa ndi metformin kumatha kubweretsa hyperglycemia (shuga wambiri wamagazi). Kugwiritsa ntchito insulini kapena sulfonylurea kapena mankhwala a glinide ndi metformin kumatha kubweretsa chiopsezo chowonjezeka cha hypoglycemia .

Mankhwala osokoneza bongo	Gulu la Mankhwala	Metformin	Metformin ER
Topiramate Acetazolamide Zonisamide Dichlorphenamide	Mpweya wa anhydrase inhibitors	Inde	Inde
Dolutegravir Cimetidine Vandetanib Ranolazine	Mankhwala omwe amachepetsa chilolezo cha metformin mthupi	Inde	Inde
Insulini	Insulini	Inde	Inde
Glimepiride Glipizide Glyburide Wobwezeretsanso Gulu	Kubisa kwa insulin	Inde	Inde
Hydrochlorothiazide Chlorthalidone Indapamide Furosemide Bumetanide Torsemide Asidi amtundu	Okodzetsa	Inde	Inde
Zamgululi Prednisone Hydrocortisone Dexamethasone Fludrocortisone	Corticosteroids	Inde	Inde
Chlorpromazine Mesoridazine Zowonjezera Thioridazine	Phenothiazines	Inde	Inde
MulembeFM	Mankhwala a chithokomiro	Inde	Inde
Mankhwala osokoneza bongo Ethinyl estradiol Wotsogola Norethindrone Desogestrel	Estrogens ndi njira zakulera zam'kamwa	Inde	Inde
Phenytoin	Antiepileptic	Inde	Inde
Niacin	Nicotinic asidi	Inde	Inde
Ephedrine	Wachifundo	Inde	Inde
Amlodipine Diltiazem Felodipine Nicardipine Nifedipine Kutumiza	Njira yoletsa calcium	Inde	Inde
Isoniazid	Maantibayotiki	Inde	Inde

Izi sizingakhale mndandanda wathunthu wazomwe zingachitike mukamagwiritsa ntchito mankhwala osokoneza bongo. Funsani dokotala ndi mankhwala onse omwe mukumwa.

Machenjezo a metformin vs. metformin ER

Metformin imatha kuyambitsa lactic acidosis nthawi zambiri. Lactic acidosis imachitika pakakhala kuti lactate ili ndi magazi ambiri. Matendawa amatha kutsika magazi, hypothermia, ngakhale kufa. Zizindikiro zina za lactic acidosis zimaphatikizapo kufooka kwachilendo, kutsegula m'mimba, kupweteka m'mimba, ndi kukokana. Pitani kuchipatala mwachangu ngati muwonetsa izi.

Metformin ikhoza kuchepa vitamini B12 milingo mthupi. Popita nthawi izi zimatha kubweretsa kuchepa kwa vitamini B12. Mavitamini a B12 amayenera kuyang'aniridwa zaka ziwiri kapena zitatu zilizonse akamamwa metformin nthawi yayitali.

Ngakhale ndizosowa, metformin imatha kuyambitsa hypoglycemia ngati itengedwa ndi insulin kapena insulin secretagogue monga glipizide kapena repaglinide. Nthawi zambiri, metformin imatha kuyambitsa hypoglycemia ikamamwa mowa kapena zakudya zosakwanira.

Mafunso omwe amafunsidwa pafupipafupi za metformin vs. metformin ER

Kodi metformin ndi chiyani?

Metformin ndi mankhwala akuchipatala omwe amavomerezedwa kuti athetse mtundu wa 2 wa matenda ashuga mwa akulu ndi ana azaka 10 kapena kupitilira apo. Kutulutsa msanga metformin nthawi zambiri kumatengedwa kawiri tsiku lililonse ndikudya. Amayesedwa ngati chithandizo choyamba cha mtundu wa 2 shuga akaphatikizidwa ndi yoyenera kadyedwe ndi masewera olimbitsa thupi .

Kodi metformin ER ndi chiyani?

Metformin ER ndiyo mawonekedwe omasulidwa a metformin. Imadziwikanso ndi mayina odziwika kuti Glucophage XR, Glumetza, kapena Fortamet. Metformin ER imatenga nthawi yayitali kuposa metformin wamba ndipo imakhala ndi zovuta zochepa. Amapatsidwa kamodzi tsiku lililonse ndi chakudya chamadzulo.

Kodi metformin ndi metformin ER ndizofanana?

Ayi. Metformin ndi metformin ER sizofanana. Metformin ndiye mtundu womwe umatulutsidwa pomwe metformin ER ndiyomwe imatulutsidwa. Metformin imavomerezedwa kuchiza matenda a shuga amtundu wa 2 mwa akulu ndi ana azaka 10 kapena kupitilira pomwe metformin ER imangovomerezedwa kuthana ndi matenda a shuga a mtundu wa 2 mwa akulu.

Kodi metformin ndi metformin ER zili bwino?

Metformin ER imawerengedwa kuti ndi njira yabwinoko chifukwa imangofunika kutengedwa kamodzi tsiku lililonse. Ndizofanana kapena zothandiza kuposa metformin ndipo sizimayambitsa zovuta zina.

Kodi nditha kugwiritsa ntchito metformin ndi metformin ER ndili ndi pakati?

Metformin itha kugwiritsidwa ntchito panthawi yapakati ngati maubwino apitilira zoopsa zake. Maphunziro a zinyama onetsani kuti palibe zotsatirapo zoyipa kwa mwana wosabadwayo. Komabe, chiopsezo cha kupunduka kwa kubadwa sichingafanane. Lankhulani ndi dokotala kuti muwone ngati metformin ili yoyenera pamene muli ndi pakati kapena mukuyamwitsa.

Kodi ndingagwiritse ntchito metformin ndi metformin ER ndi mowa?

Sikulimbikitsidwa kuti mutenge metformin kapena metformin ER ndi mowa. Kumwa mowa kumatha kusintha shuga m'magazi ndipo kumawonjezera chiopsezo cha hyperglycemia kapena hypoglycemia.