FDA ivomereza Erleada, chithandizo chatsopano cha khansa ya prostate

Nkhani

Ngakhale pali mankhwala ambiri omwe amapezeka kuchiza khansa ya prostate , mu February 2018, the Food and Drug Administration (FDA) ivomerezedwa mankhwala oyamba a zotupa zosafalikira (zotsekemera zosagwira metastatic) zotupa: Erleada (apalutamide). Chivomerezocho ndi nkhani yabwino kwambiri kwa odwala omwe ali ndi khansa ya prostate, yomwe (malinga ndi American Cancer Society) panali milandu yatsopano 174,650 ku US mu 2019 mokha.

ZOCHITIKA: Kuyambira Seputembara 2019, Erleadea adavomerezedwanso kuti agwiritsidwe ntchito kwa odwala omwe ali ndi khansa ya prostate.

Erleada vs. mankhwala a mahomoni

Nthawi zambiri, odwala omwe ali ndi khansa ya prostate amapatsidwa mankhwala amtundu wotchedwa mankhwala a mahomoni . Izi zimachepetsa kuchuluka kwa androgen m'thupi, yomwe ndi mahomoni omwe amatha kupangitsa kuti khansa ikule pakapita nthawi. Komabe, odwala ena omwe ali ndi khansa ya prostate samvera mankhwalawa. M'mbuyomu, zinali zovuta kuneneratu ngati mankhwala a mahomoni azigwira bwino ntchito pochiza khansa ya prostate ya wodwala, motero njira yoyeserera ndi yolakwika yakhala ikugwiritsidwa ntchito (ngakhale izi zikuyengedwa) .

Erleada Ndi piritsi yomwe imaperekedwa kuti imwenso kamodzi patsiku (monga mapiritsi anayi 60 mg, pamlingo wathunthu wa 240 mg tsiku lililonse). Amapangidwa kuti azigwiritsidwa ntchito pomwe mankhwala a mahomoni ndikuchepetsa kwa androgen sikokwanira kuyimitsa kukula kwa khansa ya prostate. Malinga ndi zambiri zamalonda , Erleada ayenera kuperekedwa limodzi ndi gonadotropin-release hormone (GnRH) analog (kapena wodwalayo amayenera kukhala ndi orchiectomy yapakati, zomwe zikutanthauza kuchotsa machende onse awiri).

Kuwunika koyambirira kwa FDA

Kufunsira kuvomerezedwa kudasungidwa pansi pa a FDA Kuwunika Kwambiri dongosolo, lomwe lakonzedwa kuti lifulumizitse kuwunikanso kwa mankhwala ena omwe ali ndi kuthekera kokulitsa mphamvu ya chithandizo cha matenda akulu monga khansa. Kuwunikaku kumayang'ana kuyesa kwachipatala, komwe odwala amapatsidwa Erleada kapena placebo limodzi ndi mankhwala ena. Odwala omwe adatenga Erleada adakhala ndi miyezi 40.5 yopanda metastasis, poyerekeza ndi miyezi 16.2 mwa odwala omwe adapatsidwa malowa, kutsika kwa 72% pangozi yakufa.

Zotsatira zoyipa

Mofanana ndi mankhwala ambiri omwe amagwiritsidwa ntchito pochiza khansa, pali zovuta zina zomwe zimadza chifukwa chomwa Erleada. Zotsatira zoyipa kwambiri zimaphatikizapo (koma sizimangokhala) kutopa, zotupa, kuthamanga kwa magazi, kupweteka kwamagulu, kuonda, ndi kutsegula m'mimba. Chithandizo cha khansa ya prostate ndi Erleada chingathenso kufooketsa mafupa ndi minofu, ndikuwonjezera ngozi zakugwa ndi kusweka. Erleada amatha kuyambitsa matenda amtima; Kutsekeka kwamitsempha yotsogolera kumwalira kwachitika mwa anthu ena omwe amathandizidwa ndi mankhwalawa. Palinso chiopsezo chowonjezeka cha kugwidwa mukamamwa Erleada. Mwakutero, odwala ayenera kupewa chilichonse chomwe chingachitike ngati kugwidwa kapena kutayika kwadzidzidzi kungadzipweteke kapena kuchititsa ena. Erleada amathanso kuyambitsa zovuta za chonde.

Kuyanjana ndi mankhwala ena

Erleada amatha kucheza ndi mankhwala osiyanasiyana. Erleada, polowerera ma enzyme ena, amachepetsa mphamvu ya mankhwala ena omwe amakonzedwa ndi ma enzyme omwewo. Odwala akuyenera kukambirana ndi adotolo awo, ndikuwadziwitsa za mankhwala omwe akumwa pakadali pano asanasankhe kugwiritsa ntchito Erleada.