FDA imakoka mitundu yonse ya ranitidine kumsika waku US

Nkhani

Ranitidine, wodziwika ndi dzina lakeZantac, ndi mankhwala omwe amachepetsa kupanga asidi m'mimba. Nthawi zambiri amatengedwa kuti azitha kutentha pa chifuwa ndi GERD. Pa Seputembala 13, 2019 US Food and Drug Administration (FDA) idatulutsa a mawu kulengeza zakudziwika kwa chodetsa cha nitrosamine chotchedwa N-nitrosodimethylamine (NDMA) m'mankhwala ena a ranitidine, kuphatikiza Zantac-zomwe zimapangitsa malo ena ogulitsa mankhwala kuti asiye kugulitsa zinthu zonse za ranitidine. Pa Epulo 1, 2020, a FDA adapempha opanga mankhwala kuti atenge mitundu yonse ya ranitidine kumsika waku U.S.

Nchifukwa chiyani ranitidine ikukumbukiridwa?

A FDA akhala akufufuza NDMA ndi zosafunika zina za nitrosamine mu kuthamanga kwa magazi ndi mankhwala olephera mtima otchedwa Angiotensin II Receptor Blockers (ARBs) kuyambira chaka chatha, mawu oyambawo adawerengedwa. Pankhani ya ma ARB, a FDA adalimbikitsa kukumbukira zambiri chifukwa adapeza ma nitrosamines osavomerezeka.

Tadanenanso kuti mayeso oyambira adatsimikizira kuti ranitidine ili ndi NDMA yochepa. Izi zidapangitsa makampani azogulitsa Novartis (omwe amapanga mankhwala a Zantac komanso generic a ranitidine) ndi Apotex (zomwe zimapangitsa Wal-Zan) kukumbukira zinthu zawo zonse za ranitidine zogulitsidwa ku US.

Maunyolo akuluakulu ogulitsa mankhwala adachotsa Zantac m'mashelefu awo. Mu mawu , CVS idawonetsa kuti izi zikuchitika mosamala kwambiri, ndipo lingaliro lakukoka mankhwala a mashelufu m'mashelefu lidapangidwa mwachindunji poyankha zidziwitso kuchokera ku US Food and Drug Administration (FDA) ponena kuti ranitidine Zogulitsa zitha kukhala ndi NDMA yotsika.

Mu Seputembala, Ramzi Yacoub, Chief Pharmacy Officer wa SingleCare, adalongosola, FDA idazindikira zosavomerezeka pazinthu zina za ranitidine ndipo yakumbukira mwakufuna kwawo pakadali pano. Izi sizimakhudza zinthu zonse za ranitidine pakadali pano. A FDA akupitiliza kuyesa mankhwala a ranitidine ochokera kumakina osiyanasiyana kuti awunikenso zoyipa zomwe zingachitike.

Mu Epulo chaka chino, a FDA adalengeza kuti pambuyo pofufuza, bungweli lidapeza kuti kuchuluka kwa NDMA kukuwonjezeka pakapita nthawi m'malo osungira. Mulingo wa NMDA udapezekanso kuti uchulukirachulukira pomwe ranitidine amasungidwa kutentha kwambiri. Kutanthauza, ogula atha kudziwitsidwa ndi NDMA yochulukirapo. Zotsatira izi zidapangitsa a FDA kuti atulutse zovuta kwambiri kumbukirani pempho .

Zomwe muyenera kuchita ngati mutatenga ranitidine

Anthu mamiliyoni ambiri aku America amagwiritsa ntchito mankhwala a ranitidine — mphamvu ndi mankhwala patebulo — kuti athane ndi vuto lakugaya chakudya. Ndi mankhwala ogwiritsira ntchito kwambiri a H2 omwe amaletsa zochita za histamine ndikuchepetsa kupangika kwa asidi m'mimba. M'malo mwake, ndizofala kuti anthu azimwa kawiri patsiku, kapena kupitilira apo. Omwe amapezeka ndi matenda a Zollinger-Ellison nthawi zambiri amatenga ranitidine katatu patsiku.

A FDA akukulimbikitsani kuti mulankhule ndi dokotala ngati mukumwa mankhwala a mphamvu-ranitidine musanamwe mankhwala. Aliyense amene atenga mphamvu zowonjezerapo asiyiretu kumwa, afufuze njira zina mothandizidwa ndi wamankhwala, ndikubwezera mankhwalawo kuti abwezeretsedwe. Muthanso kunena za zovuta zilizonse kapena zovuta ku FDA's MedWatch Pulogalamu Yotsutsa Zochitika Zoipa.

Kodi njira zina ndi ziti?

Ngakhale ranitidine imakumbukiridwa, aliyense amene akufuna mankhwala ochepetsa asidi nditha kupezabe mpumulo. Oletsa ma H2 ena, monga Pepcid ndipo Tagamet , akadapezekabe pakauntala kuti apereke kutentha kwa chifuwa ndi vuto la kudzimbidwa, ndipo sanakumbukiridwe.

Maantibayotiki monga Zolimbikitsa , Matamu , ndi Mylanta atha kukhala njira zabwino zakupha ndi vuto la kudzimbidwa. Kuphatikiza apo, ma proton pump inhibitors (PPIs) monga Nexium , Prilosec , ndipo Prevacid amathanso kupatsa mpumulo osadandaula za NDMA. Komabe, ma PPI ndiabwino kwambiri ndipo ali ndi mapanga omwe ayenera kukambirana ndi dokotala wanu.

Lankhulani ndi dokotala wanu poyamba

Mukamasintha mankhwala, lankhulani ndi akatswiri kuti mudziwe zomwe zilipo ndikuwona ngati njira yabwino pazosowa zanu. A FDA akuwonetsa kuti mungaganizire zinthu zina za OTC pamkhalidwe wanu, ngati kuli koyenera. Chifukwa mankhwala ambiri ochepetsa acid amangogwiritsidwa ntchito pakanthawi kochepa, dokotala wanu atha kusankha kuti asiye mankhwalawo.

Odwala omwe akufuna kusiya ranitidine ndikusintha njira ina yamankhwala ayenera kukambirana izi ndi dokotala, a Dr. Yacoub akulangiza. Pali mankhwala ena omwe amapezeka m'kalasi lomweli kapena magulu ena kuti athetse vuto lanu-koma odwala ayenera kufunsa wamankhwala kapena dokotala asanasinthe.