Kuyanjana kwa mankhwala a CBD: Kodi CBD ndiyabwino kumwa mankhwala omwe mungalandire?

Zambiri Zamankhwala

Ngati mwayendera sitolo yomwe imagulitsa zathanzi komanso zokongola posachedwapa, mwina mwawona kuti zinthu zomwe zili ndi CBD, kapena cannabidiol, zikuwoneka kuti ndizopsa mtima kwambiri. Mafuta, chokoleti, zowonjezera mavitamini, ngakhale zakumwa za kaboni, zikudzaza mashelufu — kukopa ogula ndi kunena kuti kugwiritsa ntchito imodzi mwa mankhwalawa kumachiritsa kugona, kuchepetsa nkhawa, kuchepetsa kutupa, kapena kuchiza PTSD.

Ndipo ogulitsa akugula, titero kunena kwake, lipoti laposachedwa lidawonetsa izi Kugulitsa kwa CBD akuyembekezeka kugunda $ 16 biliyoni pofika 2026, kuchokera pang'ono kupitirira $ 1 biliyoni mu 2018. Koma CBD ndi chiyani kwenikweni, ndipo ndi zotetezeka kwa anthu omwe akugwiritsa ntchito mankhwala akuchipatala? Musanagwiritse ntchito, ndikofunikira kuti muphunzire za momwe mungagwiritsire ntchito mankhwala osokoneza bongo a CBD.

Kodi chamba cha CBD?

Ngakhale CBD ndichimodzi mwazomwe zimagwiritsidwa ntchito mu chamba, kugwiritsa ntchito CBD komweko sikungakukwezeni (chinthu chomwe chimatchedwa tetrahydrocannabinol, kapena THC). CBD ilidi mamolekyulu mkati mwazomera zosiyanasiyana za chamba, ndipo pali umboni wosatsimikizika komanso kafukufuku woyambirira kuwonetsa kuti zomwe zimapangidwa kuchokera ku molekyuluyi zili ndi maubwino ena azaumoyo.

CBD imaganiziridwa kuti imagwira ntchito pama receptors ena muubongo wanu ndi ziwalo zina za thupi, m'njira zomwe zingathetsere kupweteka, kapena kuthandizira zovuta zina, monga zovuta zolanda ana. Komabe, monga chinthu chilichonse chachilengedwe, chakuti zimachokera kuzomera sizimangokhala zopanda vuto. Kwa anthu ena, makamaka omwe amamwa mankhwala akuchipatala, kugwiritsa ntchito CBD ndizowopsa. Zili ndi zotsatira za anticoagulant zomwe zimatha kuchepa magazi; amathanso kutsitsa kuthamanga kwa magazi. Izi zitha kukhala zowopsa kwa anthu omwe ali ndi matenda ena.

Zitsamba ndi mankhwala, akuti Rita Alloway, Pharm.D. , pulofesa wofufuza za nephrology ku University of Cincinnati College of Medicine. Kungoti [china] ndi mankhwala azitsamba… sizitanthauza kuti sichingagwirizane ndi mankhwala omwe mungakhale mukumwa.

Kodi CBD imagwirizana ndi mankhwala?

Mlanduwu: tacrolimus , mankhwala opatsirana pogonana omwe amagwiritsidwa ntchito popewera kukanidwa kwa ziwalo kwa odwala omwe adasinthidwa mtima, chiwindi, kapena impso. CBD imasokoneza kagayidwe ka tacrolimus, malinga ndi kafukufuku wopangidwa ndi Dr. Alloway , amene amakhazikika pambuyo kumuika immunosuppression. Ndipo chifukwa tacrolimus ndi njira yochepetsera yothandizira (kutanthauza kuti zenera pakati pa mphamvu ndi poizoni ndizochepa kwambiri), kusokonekera kumeneku kumatha kubweretsa zotsatira zoyipa zamankhwala (monga mavuto a impso kapena kukanidwa kwa ziwalo), akutero.

Kodi kuchuluka kwa malonda a CBD kuli okwanira kuti izi zitheke? Umboni sikunena kwenikweni mwanjira ina. Kafukufuku wa Dr. Alloway adakhudza kuchuluka kwa CBD komwe sikungapezeke pamalonda. Komabe, zikuwonetsa kuti kulumikizana ndi mankhwala kulipo, akutero. Kuphatikiza apo, tacrolimus imapukusidwa mthupi ndi gulu la michere yotchedwa cytochrome P450 ndi CBD ndi choletsa kudziwika za njirayi. Zimatanthauza chiyani? Ngati CBD ikuletsa kagayidwe kake ka tacrolimus, wodwalayo amatha kukhala ndi tacrolimus wambiri mthupi. Poganizira izi, amalimbikitsa aliyense amene amamwa tacrolimus kuti alankhule ndi gulu lawo lakuika asanagwiritse ntchito CBD. Musakhale ndi chiyembekezo, ngakhale-kugwiritsa ntchito mankhwala azitsamba, makamaka omwe ali ndi kuthekera kochita nawo, nthawi zambiri amakhumudwitsidwa ndi madotolo omwe akuyang'anira omwe akuwalandiranso (kuphatikiza Dr. Alloway).

Ponena za mankhwala ena, chabwino, ambiri sanaphunzirebe. Pali umboni woyambirira woti CBD itha kukhala ndi vuto lofananalo ndi msuzi wamphesa, kuwononga momwe thupi lanu limagwiritsirira ntchito mankhwala osokoneza bongo, komanso kukweza ma seramu amankhwala m'thupi lanu. Ndipo, chifukwacytochrome P450 imayambitsa kagayidwe ka mankhwala ambiri , pitirizani kusamala musanasakanize mankhwala aliwonse ndi CBD, Dr. Alloway akutero.

Nanga bwanji maubwino othandizira a CBD?

Ngakhale sizabwino kwenikweni za CBD kwa odwala omwe amagwiritsa ntchito tacrolimus, kwa anthu ena, CBD imasinthiratu moyo wawo mwanjira yabwino. Mwachitsanzo, mu 2018, mankhwala omwe amachokera ku CBD Epidiolex adalandira Kuvomerezeka ndi FDA zochizira matenda a Lennox-Gastaut ndi matenda a Dravet, mitundu iwiri yosowa kwambiri komanso yovuta kwambiri ya khunyu.

Koma zonena kuti zothandizira ku CBD pochiza matenda ena amisala komanso zamisala, sizidutsa, akutero Roger McIntyre, MD , pulofesa wa zamisala komanso zamankhwala ku University of Toronto.

Palibe gawo pakadali pano la CBD pakuthana ndi zovuta zamaganizidwe zomwe [ndimachiza], monga kukhumudwa, matenda ochititsa munthu kusinthasintha zochitika… nkhawa ndi ADHD, akutero. Tilibe chabe umboni womwe umachirikiza.

Kuphatikiza apo, mankhwala ambiri akuchipatala omwe amagwiritsidwa ntchito kuthana ndi mavutowa amapangidwa ndi cytochrome P450, zomwe zimapangitsa kuti CBD isokoneze chithandizo - m'malo mopititsa patsogolo chithandizo.

Dr. McIntrye, yemwe adalemba nawo a Phunziro la 2018 omwe adamaliza kunena kuti othandizira zaumoyo amafunikira zambiri za kuyanjana ndi mankhwala osokoneza bongo ndi CBD ndi mankhwala a psychotropic, akuti zambiri zakomwezi ndizosokoneza komanso zotsutsana. Chifukwa chake, akunenanso mawu a Dr. Alloway kuti ndichachidziwikire kuti odwala amachotsa kugwiritsa ntchito CBD ndi dokotala wawo asanapereke mwayi.

[Woperekayo] amamudziwa payekha ndipo amadziwa mankhwala ena omwe angawatenge kapena sangamwe, akufotokoza Dr. McIntyre. Amakhala ndi malingaliro owoneka bwino a mankhwala a wodwalayo, ndipo amakhala [ndi lingaliro labwino] ngati wodwalayo akutenga mankhwala ena omwe atha kuyanjana.