Momwe mankhwala a shuga Metformin angagwiritsidwire ntchito pochizira PCOS

Zambiri Zamankhwala

Polycystic Ovary Syndrome (PCOS) ndi vuto la mahomoni zomwe zimakhudza pafupifupi 5 miliyoni akazi ku United States. Zizindikiro za PCOS zimasiyanasiyana malinga ndi munthu, zomwe zimapangitsa kuti zikhale zovuta kuzizindikira. Amayi ambiri amavutika mwakachetechete, amakhala osazindikira kwa zaka zambiri.

Mabungwe osapindulitsa ku US konse amagwira ntchito kuti afalitse anthu za zizindikilo ndi njira zamankhwala zomwe zingapezeke-kuyambira pa kubereka mpaka metformin. Koma imakhalabe imodzi mwazovuta kwambiri, zosasungidwa, zomwe sizikupezeka komanso zopanda ndalama zomwe zimakhudza thanzi la amayi, akuti Sasha Ottey, director director wa PCOS Challenge Inc. yopanda phindu

Chifukwa chiyani azimayi ena amatenga PCOS, ndipo zimawakhudza bwanji?

Dr. Felice Gersh , OB-GYN wopambana mphotho, akuti PCOS ndiye vuto lomwe limafala kwambiri kwa azimayi obereka-koma limakhudza gawo lililonse la thupi la mkazi. Zimakhudza ntchito zonse zamagetsi komanso mbali zonse za msambo ndi chonde. Zizindikiro zofala Zitha kuphatikizira: palibe nthawi, nthawi yokhazikika, kapena nthawi yolemetsa; kupweteka kwa m'chiuno; kukula kwa tsitsi pankhope panu, lotchedwa hirsutism; ziphuphu; kunenepa kapena zovuta zolemetsa thupi; ndi zigamba za khungu lakuda bii.Malinga ndi EndrocrineWeb , azimayi omwe ali ndi PCOS atha kukhala ndi zotupa 25 kapena kupitilira apo pa ovary imodzi.

Pali fayilo ya zifukwa zosiyanasiyana chifukwa chomwe mkazi wazaka zoberekera atha kukhala ndi PCOS, koma kafukufuku akuwonetsa kuti ma genetics, insulin kukana, komanso kuchuluka kwa androgen (yemwenso amadziwika kuti mahomoni achimuna) ndizomwe zimawopsa.

PCOS imakhudza azimayi ochokera kosiyanasiyana. Amayi amitundu yonse ndi mafuko ali pachiwopsezo cha PCOS, akutero Dr. Kate Killoran OB-GYN ku Maine. Amayi ndi akazi onenepa kwambiri omwe ali ndi mbiri yakubanja nthawi zambiri amakhudzidwa.

Kodi mankhwala a PCOS ndi ati?

Ngakhale kulibe mankhwala a PCOS, pali njira zothetsera zizindikilo. Ndondomeko ya chithandizo cha wodwala aliyense idzakhala yosiyana pang'ono, kutengera mitundu yawo yazizindikiro.

Dr. Killoran akuti pali mankhwala ochepa omwe angaperekedwe kwa odwala PCOS, kutengera momwe matendawa amawakhudzira. Uwu si mndandanda wathunthu, koma umaphatikizapo:

• Kulera Zitha kuthandizira kuthana ndi zovuta zamsambo.
• Njira zolerera pakamwa zomwe zili ndi estrogen Zitha kuthandiza kukonza ziphuphu.
• Metformin kapena mankhwala ena amtundu wa insulini amatha kuthandizira pazovuta zamagetsi komanso kusintha chonde.
• Letrozole itha kuyambitsa ovulation pomwe azimayi omwe ali ndi PCOS akuyesera kutenga pakati.

Kusintha kwa moyo, makamaka masewera olimbitsa thupi komanso kusintha kwa zakudya zopatsa mphamvu kumatha kusintha kapena kusintha PCOS, Dr. Killoran akuwonjezera.

Kodi metformin imatani pa PCOS?

Metformin ndi mankhwala wamba omwe amagwiritsidwa ntchito pochiza PCOS. Idapangidwa koyambirira ndipo imaperekedwa kuti ichiritse Matenda a shuga a mtundu wachiwiri, matenda amadzimadzi ofanana ndi PCOS, akuti Dr. Laurence Gerlis , dokotala ku London, England.

Udindo wa metformin mthupi ndikuwongolera shuga wamagazi pothandiza thupi kuyankha bwino ku insulini yomwe imapanga mwachilengedwe, kuchepetsa kuchuluka kwa shuga komwe chiwindi chimapanga, ndikuchepetsa shuga omwe matumbo amayamwa pachakudya, malinga ndi Chakudya ndi Administration Administration (FDA).

Dr. Gerlis akuti metformin ya PCOS, ikagwiritsidwa ntchito pafupipafupi, imachepetsa magazi m'magazi poyeserera kuchuluka kwa insulin ndikuchepetsa zovuta zina zamavuto amtunduwu.

Kodi pali zovuta zoyipa zotenga metformin ya PCOS?

Pali zochepa zochepa zokhudzana ndi chitetezo chokhudzana ndi kagwiritsidwe ntchito ka metformin, kupatula kumasula matumbo, Dr. Gerlis akuti. Gasi, kutsekula m'mimba, ndi kupweteka m'mimba ndi zovuta zina za metformin.

Dokotala Gersh, kumbali inayo, sapereka mankhwala a metformin kwa odwala ake chifukwa amadziwika kuti ndi kusokoneza kwa endocrine ndi asayansi ena azachilengedwe. Ngakhale pali mikangano yambiri pozungulira iwo, ma endocrine osokoneza akhala akuganiziridwa kuti akuphatikizidwa ndimasinthidwe antchito oberekera, khansa ya m'mawere, momwe amakulira mosalekeza, ndi zina zambiri.

Kodi ndiyenera kutenga metformin yochuluka motani pa PCOS? Kodi metformin iyenera kutengedwa nthawi yayitali bwanji pa PCOS?

Palibe mgwirizano pamlingo wokhazikika kapena kutalika kwa metformin ya PCOS; mlingo wapakati ndi 1,500 mg tsiku lililonse. Madokotala nthawi zambiri yambitsani odwala pa 500 mg tsiku ndi tsiku, ndikuwonjezera mlingo pang'onopang'ono kuti muchepetse zovuta za metformin.

Metformin imapezeka kudzera mu mankhwala okhaokha, ndipo idavomerezedwa ndi Food and Drug Administration (FDA) in 1994 ku United States. Metformin amatengedwa pakamwa, ndipo ali zilipo pansi pamalondaZolemba, Glucophage , Nthabwala , ndi Riomet.

Popeza metformin imakhazikika bwino komanso imakhala yotetezeka, ndikulimbikitsidwa kuyiyambitsa koyambirira kwa kasamalidwe ka PCOS, Dr. Gerlis akulangiza.

Kodi metformin imathandiza bwanji PCOS ndi kuchepa thupi? Kodi metformin imathandizira bwanji kusabereka?

Pochepetsa thupi komanso kusabereka, mphamvu ya metformin siyodulidwa bwino.

Dr. Killoran akuti odwala omwe ali ndi PCOS omwe angafune kuyesa mankhwala a metformin kuti athetse matenda awo amakhala onenepa kwambiri kapena onenepa kwambiri ndipo amayesera kutenga pakati, kapena akuyesera kupewa matenda amadzimadzi, matenda amtima, kapena kukulitsa matenda a shuga.

Ngakhale kugwiritsa ntchito metformin kumayenderana ndi kuchepa kwa thupi, zotsatira zake sizikugwirizana, akutero.

Kodi pali njira zina zachilengedwe zopangira metformin ya PCOS?

Dr. Gersh amakhulupirira kuti njira imodzi yothanirana ndi PCOS ndi kusintha kwa moyo ndi zizolowezi zatsopano, monga kudya zakudya zopangidwa ndi mbewu, kuchepetsa kupsinjika, kuganizira kugona, komanso kuchita masewera olimbitsa thupi. Mankhwala achilengedwe omwe amalimbikitsidwa kwambiri pa PCOS akupeza njira zolimbikira ndikudya zakudya zambiri.

Kwa odwala ake, Dr. Gersh amalimbikitsa mavitamini osiyanasiyana, mogwirizana ndi kusintha kwa zakudya ndi masewera olimbitsa thupi kuti athetse matenda a PCOS. Mwachitsanzo, vitamini B12 ingalimbikitsidwe kuti imwetsedwe kapena itatha mankhwala a metformin, chifukwa malabsorption a vitamini B12 atha kukhala zotsatira za metformin ngati agwiritsidwa ntchito nthawi yayitali.

Pakadali pano, a Dr. Killoran ati PCOS imakhudza munthu aliyense mosiyanasiyana. Akuti ndikofunikira kuchiza PCOS ngakhale zizindikiro za wodwalayo sizikuvutitsa, komabe. Onse ayenera kudziwa kuopsa kwawo pamavuto azachipatala amtsogolo monga matenda amadzimadzi ndi matenda amtima, amalangiza. Lingaliro lakuchiza PCOS ndi zomwe ziyenera kukhazikika pazizindikiro za mkazi komanso kuchepetsa chiopsezo.

Ngati mukuganiza za metformin, pangani dongosolo lotsatira ndi dokotala wanu kuti muwone zomwe zili zoyenera kwa inu.