Eliquis vs Warfarin: Kusiyana Kwakukulu ndi Kufanana

Mankhwala osokoneza bongo Vs. Mnzanu

Mwina mudamvapo za Eliquis (apixaban) ndi warfarin ngati mwapezeka kuti muli ndi vuto lomwe limafuna kugwiritsa ntchito anticoagulant. Kupanda kutero amadziwika kuti opopera magazi, Eliquis ndi warfarin atha kugwiritsidwa ntchito popewa kupangika kwa magazi. Poletsa magazi kuundana, mankhwalawa amachepetsa chiopsezo cha zinthu monga deep vein thrombosis (DVT) ndi stroke mu atrial fibrillation. Ngakhale mankhwala onsewa ali ndi ntchito zofananira, amasiyana m'njira zingapo.

Eliquis

Eliquis (Eliquis ndi chiyani?) Ndi dzina la apixaban. Imagwira ngati inhibitor yosankha ya factor Xa, chinthu chofunikira pakupanga ma clot. Poletsa mwachindunji chigawochi, kuchepa kwa platelet ndi thrombus kumachepetsa komwe kumachepetsa magazi.

Eliquis akuwonetsedwa kuti amachepetsa chiwopsezo cha kupwetekedwa ndi dongosolo la embolism mwa odwala omwe ali ndi ma nonvalvular atrial fibrillation. Itha kugwiritsidwanso ntchito kupewetsa ndikuchiza kwambiri vein thrombosis (DVT) ndi pulmonary embolism (PE) mwa anthu ena.

Eliquis imatha kuperekedwa ngati mapiritsi amlomo a 2.5 mg ndi 5 mg. Pakadali pano, palibe piritsi lodziwika bwino lomwe likupezeka. Mlingo woyenera umasiyanasiyana kutengera momwe akuchiritsira. Mosasamala mphamvu zake, nthawi zambiri amathiridwa kawiri tsiku lililonse. Kuwunika pamiyeso yamalabu ndi INR sikofunikira kwenikweni ndi mankhwalawa.

Kusintha kwa dosing kuyenera kupangidwa mwa iwo omwe ali ndi zosachepera 2 za izi: zaka za 80 zakubadwa kapena kupitilira, kulemera kwa thupi kapena ochepera 60 kg (pafupifupi 132 lbs), kapena serum creatinine kapena wamkulu kuposa 1.5 mg / dL . Kugwiritsa ntchito Eliquis sikuvomerezeka kwa odwala apakati kapena omwe ali ndi vuto lalikulu la chiwindi.

Mukufuna mtengo wabwino kwambiri pa Eliquis?

Lowani zidziwitso zamitengo ya Eliquis kuti mudziwe kuti mitengo isintha liti!

Pezani zidziwitso zamitengo

Warfarin

Warfarin (Kodi Warfarin ndi chiyani?) Ndi dzina lodziwika bwino la Coumadin. Zimalepheretsa kutsekedwa kwa magazi ngati wotsutsana ndi vitamini K. Vitamini K ndichinthu chofunikira kwambiri chomwe chimafunika pamodzi ndi zinthu zina kuti apange minyewa mthupi. Poletsa vitamini K, kuundana kwatsopano sikungapangike.

Warfarin imawonetsedwa kuti imachiza ndikupewa ma DVTs ndi ma PE mofanana ndi Eliquis. Amagwiritsidwanso ntchito pochiza ndikupewa zovuta zamagazi zomwe zimatha kubwera ndi kutaya kwamatenda ndikusintha kwa valavu yamtima. Kuphatikiza apo, warfarin imatha kuchepetsa chiopsezo chamtsogolo cha matenda amtima ndi sitiroko mutadwala matenda amtima.

Mosiyana ndi Eliquis, warfarin imapezeka ngati mankhwala abwinobwino m'mapiritsi apakamwa okhala ndi mphamvu ya 1 mg, 2 mg, 2.5 mg, 3 mg, 4 mg, 5 mg, 6 mg, 7.5 mg, ndi 10 mg. Mankhwala a Warfarin amasintha kwambiri kutengera momwe amathandizira kuchipatala. Chifukwa cha mphamvu zosiyanasiyana zomwe zilipo, warfarin dosing ndiyosunthika komanso yopangidwa mwapadera kwambiri.

INR, kapena kuchuluka kwapadziko lonse lapansi, kuyenera kuyang'aniridwa pafupipafupi mukamamwa mankhwalawa popeza milingo iyi imazindikira kusintha kwa dosing, zakudya, ndi zina. Magulu azachiritso a INR amakhala pakati pa 2.0 ndi 3.0.

Pezani khadi yochotsera mankhwala

Eliquis vs Warfarin Mbali ndi Kuyerekeza Kwachiphamaso

Eliquis ndi warfarin ndi ma anticoagulants awiri omwe ali ndi mawonekedwe ofanana. Amakhalanso ndi zosiyana zingapo momwe amagwirira ntchito komanso momwe amagwirira ntchito ndi mankhwala ena. Zofanana ndi zosiyana izi zitha kufufuzidwa pansipa.

Eliquis	Warfarin
Yotchulidwa Kwa
Sitiroko ndi chiopsezo cha embolism mu fibrillation ya atvalvular Chithandizo cha DVT ndi PE DVT ndi PE prophylaxis	Kupewa ndi kuchiza zovuta kuchokera ku fibrillation ya atrial ndikusintha kwa valavu yamtima Kuchepetsa chiopsezo cha imfa, matenda amtima obwerezabwereza, ndi sitiroko pambuyo povulala kwamtima koyamba Chithandizo cha DVT ndi PE DVT ndi PE prophylaxis
Gulu la Mankhwala
Wotsutsa Factor Xa choletsa	Wotsutsa Wotsutsana ndi Vitamini K
Wopanga
Mtengo wa magawo Bristol-Myers Squibb	Zowonjezera
Zotsatira zoyipa
Magazi Kulalata Kutuluka magazi m'kamwa Msambo wambiri Mphuno imatuluka magazi	Magazi Kulalata Kutuluka magazi m'kamwa Msambo wambiri Mphuno imatuluka magazi Alopecia Kutupa
Kodi pali generic?
Palibe generic yomwe ilipo	Palibe generic yomwe ilipo
Kodi imakhala ndi inshuwaransi?
Zimasiyanasiyana malinga ndi omwe amakupatsani	Zimasiyanasiyana malinga ndi omwe amakupatsani
Mafomu a Mlingo
Piritsi lapakamwa	Piritsi lapakamwa
Avereji ya Mtengo wa Cash
497 (pa mapiritsi 60)	43 (pa mapiritsi 100)
Mtengo Wotsatsa Wa singleCare
Mtengo wa Eliquis	Mtengo wa Warfarin
Kuyanjana kwa Mankhwala Osokoneza bongo
P-gp ndi CYP3A4 zoletsa P-gp ndi CYP3A4 inducers Maantibayotiki Othandizira ma antiplatelet NSAIDs	CYP2C9 zoletsa Othandizira a CYP2C9 CYP1A2 zoletsa Othandizira a CYP1A2 CYP3A4 zoletsa Othandizira a CYP3A4 Maantibayotiki Othandizira ma antiplatelet NSAIDs SSRIs
Kodi nditha kugwiritsa ntchito pokonzekera kutenga pakati, kutenga pakati, kapena kuyamwitsa?
Eliquis ali mgulu la Mimba B. Palibe maphunziro odzipereka omwe amayesa Eliquis mwa amayi apakati. Funsani dokotala pazomwe mungachite ngati mukukonzekera kutenga pakati kapena kuyamwitsa.	Warfarin ili m'gulu la Mimba X. Warfarin itha kuyambitsa vuto la fetus ndipo imatsutsana kuti igwiritsidwe ntchito kwa amayi apakati.

Chidule

Eliquis ndi warfarin ndi mankhwala awiri a anticoagulant omwe amagwira ntchito m'njira zosiyanasiyana. Eliquis amachita ngati Xa inhibitor pomwe warfarin ndi wotsutsana ndi vitamini K. Ngakhale amasiyana pamachitidwe, amatulutsa mphamvu yomweyo.

Onse a Eliquis ndi warfarin ali ndi zisonyezo zofananira zochizira komanso kupewa thrombosis (DVTs ndi PEs). Ngakhale Eliquis imatha kuletsa zovuta kuchokera ku fibrillation ya atvalvular, warfarin imatha kuthana ndi kupewa zovuta kuchokera ku fibrillation ya atrial komanso / kapena kusintha kwa valavu yamtima. Warfarin ndi FDA yomwe imavomerezedwa kuti ipewe kufa kwamtima, kupwetekedwa mtima, ndi matenda amtima mwa iwo omwe adwala kale mtima.

Eliquis atha kusankhidwa ndi munthu amene safuna kuyang'aniridwa pafupipafupi pama labs a INR. Malinga ndi kafukufuku wa ARISTOTLE, a Eliquis awonetsedwanso kuti amachepetsa chiwopsezo cha sitiroko, chiopsezo chotsika magazi kwambiri, komanso amachepetsa kufa kwa anthu poyerekeza ndi warfarin. Chovuta chimodzi ku Eliquis ndiye mtengo wokwera chifukwa chosowa kwamankhwala omwe amapezeka pamsika.