Latuda vs. Abilify: Kusiyana, kufanana, ndi zomwe zili zabwino kwa inu
Mankhwala osokoneza bongo Vs. MnzanuKuwunika kwa mankhwala osokoneza bongo & kusiyana kwakukulu | Zinthu zothandizira | Mphamvu | Kuphunzira inshuwaransi ndikufanizira mtengo | Zotsatira zoyipa | Kuyanjana kwa mankhwala | Machenjezo | FAQ
Latuda (lurasidone) ndi Abilify (aripiprazole) ndi mankhwala omwe amagwiritsidwa ntchito pochiza schizophrenia. Matenda achizungu ndimatenda amisala omwe amakhala ndi zizindikilo monga zonyenga, kuyerekezera zinthu m'maganizo, komanso kusalankhula bwino kapena kuchita zinthu mwadongosolo. Kuphatikiza pa schizophrenia, Latuda ndi Abilify amathanso kuchiritsa matenda ena amisala.
Onse a Latuda ndi Abilify amadziwika kuti ndi antipsychotic, kapena antipychotic m'badwo wachiwiri. Amagwira ntchito m'njira zofananira kuti athe kuchepetsa zizindikilo za schizophrenia. Ngakhale njira yeniyeni yomwe amagwirira ntchito siyikudziwika, mankhwala a antipsychotic amalumikizana ndi dopamine ndi serotonin receptors muubongo.
Kodi pali kusiyana kotani pakati pa Latuda ndi Abilify?
Kusiyanitsa kwakukulu pakati pa Latuda ndi Abilify ndikuti ali ndizosakaniza zosiyanasiyana. Latuda ili ndi lurasidone ndipo Abilify ili ndi aripiprazole.
Latuda adavomerezedwa ndi FDA ku 2010 kuti athetse matenda a schizophrenia and bipolar depression. Amapezeka ngati piritsi lokamwa lamphamvu la 20 mg, 40 mg, 60 mg, 80 mg, ndi 120 mg. Latuda amafika pamlingo wokwanira m'thupi pasanathe ola limodzi kapena atatu. Latuda nthawi zambiri imayamba pa 20 kapena 40 mg patsiku kutengera momwe akuchiritsidwira, ndipo ayenera kumwa ndi chakudya chokwanira .
Abilify idavomerezedwa ndi FDA ku 2002 kuti ichiritse schizophrenia ndi matenda ena amisala, monga matenda amisala, matenda a autistic, ndi matenda a Tourette. Abilify imapezeka ngati piritsi yamlomo mwamphamvu za 2 mg, 5 mg, 10 mg, 15 mg, 20 mg, ndi 30 mg. Imabweranso ngati piritsi lowonongeka pakamwa, yankho la m'kamwa, ndi jakisoni. Limbikitsani mapiritsi amkamwa kuti afike pachimake m'thupi mkati mwa maola atatu kapena asanu mutayendetsa, ndipo amatha kumwa kapena wopanda chakudya.
| Kusiyana kwakukulu pakati pa Latuda ndi Abilify | ||
|---|---|---|
| Latuda | Limbikitsani | |
| Gulu la mankhwala osokoneza bongo | Mankhwala oletsa antipsychotic | Mankhwala oletsa antipsychotic |
| Chizindikiro cha Brand / generic | Ma brand ndi generic amapezeka | Ma brand ndi generic amapezeka |
| Kodi dzina lachibadwa ndi liti? | Lurasidone | Aripiprazole |
| Kodi mankhwalawa amabwera mwa mawonekedwe ati? | Piritsi lapakamwa | Piritsi lapakamwa Piritsi lomwe limasweka pakamwa Yankho pakamwa Ufa kuyimitsidwa jekeseni mu mnofu |
| Kodi mulingo woyenera ndi uti? | Schizophrenia mwa akulu: 40 mpaka 160 mg patsiku Schizophrenia mu achinyamata (13 mpaka 17 wazaka): 40 mpaka 80 mg patsiku | Schizophrenia mwa akulu: 10 mpaka 15 mg patsiku Schizophrenia mwa achinyamata (13 mpaka 17 wazaka): 2 mpaka 10 mg patsiku |
| Kodi mankhwalawa amatenga nthawi yayitali bwanji? | Zimasintha: odwala ayenera kuyesedwa nthawi ndi nthawi | Zimasintha: odwala ayenera kuyesedwa nthawi ndi nthawi |
| Ndani amagwiritsa ntchito mankhwalawa? | Akuluakulu, achinyamata, ndi ana azaka 10 kapena kupitilira apo (zimatengera momwe akuchiritsira) | Akuluakulu, achinyamata, ndi ana azaka 6 kapena kupitilira apo (zimatengera momwe akuchiritsira) |
Zomwe amathandizidwa ndi Latuda ndi Abilify
Latuda amagwiritsidwa ntchito pochiza schizophrenia kwa akulu ndi ana omwe ali ndi zaka 13 kapena kupitirira. Amavomerezedwanso kuti athetse magawo okhumudwitsa omwe amabwera chifukwa cha matenda ochititsa munthu kusinthasintha zochitika pakati pa akulu ndi ana omwe ali ndi zaka 10 kapena kupitirira.
Abilify imagwiritsidwanso ntchito pochiza schizophrenia kwa akulu ndi ana omwe ali ndi zaka 13 kapena kupitirira. Komabe, mosiyana ndi Latuda, amavomerezedwa kuti athetse magawo osakanikirana kapena amisala okhudzana ndi matenda ochititsa munthu kusinthasintha zochitika kwa akulu ndi ana azaka 10 kapena kupitirira. Abilify amathanso kuthana ndi vuto la Tourette, kapena Matenda a Tourette , ndi kukwiya komwe kumakhudzana ndi vuto la autistic. Mukapatsidwa mankhwala owonjezera opanikizika, Abilify amatha kuthana ndi vuto lalikulu lachisokonezo (MDD). Letsani jakisoni ndi FDA yovomerezedwa kuti ithetse zizindikiro zakusokonekera kuchokera ku schizophrenia ndi bipolar mania.
| Mkhalidwe | Latuda | Limbikitsani |
| Matenda achizungu | Inde | Inde |
| Matenda osokoneza bongo | Inde | Inde |
| Kusokonezeka kwakukulu | Ayi | Inde |
| Matenda a Autistic | Ayi | Inde |
| Matenda a Tourette | Ayi | Inde |
Kodi Latuda kapena Abilify ndiyothandiza kwambiri?
Latuda ndi Abilify onse ndi mankhwala othandiza kuchiza schizophrenia, yayikulu matenda amisala . Chithandizo chabwino kwambiri chimadalira pazinthu monga momwe akuchiritsidwira, zoyipa zomwe zingachitike, komanso mtengo wake.
Kufufuza meta kumodzi kunafanizira ma antipsychotic monga lurasidone, olanzapine, quetiapine, risperidone, ndi paliperidone. Ofufuza apeza kuti lurasidone anali ofanana ndi ma antipsychotic ena zochizira schizophrenia. Komabe, lurasidone idapezeka kuti ilibe kunenepa kwambiri komanso imakhala ndi zovuta zochepa poyerekeza ndi ma antipsychotic ena.
Kusanthula kwina kwa meta kuchokera pa World Journal of Biological Psychiatry poyerekeza lurasidone ndi ma antipsychotic ena pochiza kupsinjika kwamaganizidwe. Oposa mayesero 10 azachipatala omwe ali ndi odwala opitilira 6,000 adayesedwa pakuwunika. Antipsychotic, monga lurasidone, quetiapine, aripiprazole, olanzapine, ndi ziprasidone, adafaniziridwa poteteza chitetezo. Kafukufukuyu adatsimikiza kuti lurasidone itha kukhala yothandiza kwambiri kuposa aripiprazole ndi ziprasidone, ndipo itha kuyambitsa kunenepa pang'ono komanso kuwodzera kuposa ma antipsychotic ena.
Funsani wothandizira zaumoyo kuti akuthandizeni.
Kuphatikiza ndi kuyerekezera mtengo kwa Latuda vs. Abilify
A FDA avomereza mtundu wa Latuda. Komabe, mtundu wa generic mwina ukhoza kupezeka pamsika. Monga mankhwala odziwika bwino, Latuda akhoza kukhala okwera mtengo ngakhale atakhala ndi inshuwaransi. Medicare ndi mapulani a inshuwaransi nthawi zambiri amalipira Latuda, ngakhale ma copays amatha kusiyanasiyana m'mapulani osiyanasiyana. Mtengo wamtengo wa Latuda ndi $ 1,783.52. Coupon ya singleCare imatha kuchepetsa mtengo mpaka pafupifupi $ 1,200.
Abilify imapezeka ngati mankhwala achibadwa komanso mayina. Ma Medicare ambiri ndi mapulani a inshuwaransi adzakwaniritsa Abilify. Poyerekeza ndi Latuda, Abilify itha kukhala njira yotsika mtengo. Komabe, mtengo wamtengo ukadakhalabe wokwera pafupifupi $ 1,059.99. Khadi lochotsera la SingleCare la Abilify litha kutsitsa mtengo mpaka $ 100.
| Latuda | Limbikitsani | |
| Nthawi zambiri amakhala ndi inshuwaransi? | Inde | Inde |
| Nthawi zambiri amakhala ndi Medicare Part D? | Inde | Inde |
| Kuchuluka | Mapiritsi 30 (40 mg) | Mapiritsi 30 (5 mg) |
| Wopanga Medicare wamba | $ 7– $ 46 | $ 3 mpaka $ 204 |
| Mtengo wosakwatiwa | $ 1,236 + | $ 65 + |
Zotsatira zoyipa za Latuda vs. Abilify
Zotsatira zoyipa kwambiri za Latuda zimaphatikizapo kugona tulo, kusakhazikika kapena kufuna kuyendayenda (akathisia), nseru, ndi kusanza. Zotsatira zina za Latuda zitha kuphatikizira kuuma kwa minofu, kunjenjemera, ndi kunenepa.
Zotsatira zoyipa kwambiri za Abilify zimaphatikizapo kunyoza, kusanza, kusanza kapena kuwodzera, chizungulire, kudzimbidwa, kupweteka mutu, kusawona bwino, akathisia, ndi kusowa tulo. Zotsatira zoyipa za Abilify zimaphatikizapo kuuma kwa minofu ndi kunenepa.
Onse a Latuda ndi Abilify amatha kuyambitsa shuga wambiri wamagazi ndi ma cholesterol m'mwazi. Zotsatira zoyipa za Latuda ndi Abilify zitha kuphatikizira kuchuluka kwama cell oyera, kukomoka, kutsika kwa magazi (orthostatic hypotension), ndi kusayenda kosalamulirika kwa thupi (tardive dyskinesia).
Onani pansipa zotsatira zina zoyipa za Latuda ndi Abilify.
| Latuda | Limbikitsani | |||
| Zotsatira zoyipa | Zoyenera? | Pafupipafupi | Zoyenera? | Pafupipafupi |
| Kusinza | Inde | 17% | Inde | 5% |
| Akathisia | Inde | 13% | Inde | 13% |
| Nseru | Inde | 10% | Inde | khumi ndi zisanu% |
| Kusanza | Inde | 8% | Inde | khumi ndi chimodzi% |
| Kudzimbidwa | Inde | 6% | Inde | 9% |
| Kusowa tulo | Inde | 5% | Inde | 18% |
| Kuda nkhawa | Inde | 5% | Inde | 17% |
| Chizungulire | Inde | 5% | Inde | 3% |
| Kulemera | Inde | 3% | Inde | 3% |
| Ululu wammbuyo | Inde | 3% | Ayi | - |
| Masomphenya olakwika | Inde | * | Inde | 3% |
| Pakamwa pouma | Inde | * | Inde | 5% |
| Kudzimbidwa | Ayi | - | Inde | khumi ndi chimodzi% |
| Mutu | Ayi | - | Inde | 10% |
| Kupweteka kwa minofu | Ayi | - | Inde | awiri% |
* sananene
Pafupipafupi sizidalira zomwe zimayesedwa pamutu. Izi sizingakhale mndandanda wathunthu wazovuta zomwe zingachitike. Chonde onani dokotala wanu kapena wothandizira zaumoyo kuti mudziwe zambiri.
Gwero: DailyMed ( Latuda ), Tsiku Lililonse ( Limbikitsani )
Kuyanjana kwa mankhwala a Latuda vs. Abilify
Latuda ndi Abilify zimapukusidwa kwambiri m'chiwindi ndi enzyme ya CYP3A4. Kugwiritsa ntchito kwawo kuyenera kupewedwa, kusinthidwa, kapena kuyang'aniridwa mukaphatikizidwa ndi mankhwala omwe amakhala ngati CYP3A4 inhibitors kapena CYP3A4 inducers. Mankhwala omwe amakhala ngati CYP3A4 inhibitors, monga ketoconazole ndi ritonavir, amatha kuyambitsa kuchuluka kwa Latuda kapena Abilify ndikuwonjezera chiopsezo cha zotsatirapo. Mankhwala omwe amakhala ngati CYP3A4 inducers, monga rifampin ndi carbamazepine, atha kuyambitsa kuchepa kwa Latuda kapena Abilify ndikuchepetsa mphamvu ya antipsychotic. Kuphatikiza Abilify ndi CYP2D6 inhibitors, monga quinidine ndi fluoxetine, kumatha kubweretsa kuchuluka kwa Kuchepetsa milingo ndi zotsatirapo zake.
Kugwiritsa ntchito Latuda ndi Abilify kungafune kuyang'aniridwa kapena kupewa ngati mukugwiritsa ntchito mankhwala osokoneza bongo kapena benzodiazepines. Kumwa mankhwala a antipsychotic ndi antihypertensive kungapangitse kuti magazi azithamanga kwambiri. Benzodiazepines imatha kuphatikiza zovuta zoyipa za Latuda kapena Abilify.
| Mankhwala osokoneza bongo | Gulu la mankhwala osokoneza bongo | Latuda | Limbikitsani |
| Ketoconazole Fluconazole Clarithromycin Mankhwalawa Ritonavir Diltiazem Kutumiza | CYP3A4 zoletsa | Inde | Inde |
| Rifampin Phenytoin Carbamazepine Efavirenz Etravirine St. John's Wort | Othandizira a CYP3A4 | Inde | Inde |
| Quinidine Fluoxetine Paroxetine | CYP2D6 zoletsa | Ayi | Inde |
| Amlodipine Lisinopril Losartan | Zotsutsana | Inde | Inde |
| Alprazolam Diazepam MulembeFM | Benzodiazepines | Inde | Inde |
Funsani katswiri wa zamankhwala pazinthu zina zomwe zingagwiritsidwe ntchito ndi mankhwala
Machenjezo a Latuda ndi Abilify
Onse a Latuda ndi Abilify amakhala ndi machenjezo a mabokosi akuda. Pali chiopsezo chowonjezeka chakufa ndi matenda amisala okhudzana ndi matenda amisala pomwe mankhwala a antipsychotic amatengedwa ndi okalamba. Malingaliro odzipha ndi machitidwe nawonso adanenedwa mwa ana ndi achinyamata omwe akugwiritsa ntchito Latuda ndi Abilify. Odwala achichepere angafunike kuyang'aniridwa chifukwa cha kukulira kwa zizindikilo kapena kusintha kwamachitidwe akamatenga Latuda kapena Abilify.
Pali chiopsezo chowonjezeka chazovuta zam'magazi, monga kupwetekedwa ndi ziwonetsero zosakhalitsa za ischemic, mwa okalamba omwe ali ndi matenda amisala. Kutenga Latuda kapena Abilify kumakhalanso pachiwopsezo cha matenda oopsa a neuroleptic (NMS), zomwe zimatha kuyambitsa zizindikilo monga kutentha thupi kwambiri, kuuma kwa minofu, kusokonezeka, komanso kusintha kwa kugunda kwa mtima. NMS ndi vuto lalikulu lomwe limafunikira kuchipatala mwachangu.
Latuda ndi Abilify zingayambitse kusintha kwa kagayidwe kake, monga shuga wambiri wamagazi, kuchuluka kwama cholesterol, komanso kunenepa. Mankhwalawa amathanso kuyambitsa kuchuluka kwama cell oyera, kukomoka, komanso kuthamanga magazi.
Funsani wothandizira zaumoyo kuti akuchenjezeni ndi zodzitetezera musanagwiritse ntchito Latuda kapena Abilify.
Mafunso omwe amafunsidwa pafupipafupi za Latuda vs. Abilify
Latuda ndi chiyani?
Latuda ndi mankhwala osokoneza bongo omwe amagwiritsidwa ntchito pochiza schizophrenia ndi magawo okhumudwa omwe amabwera chifukwa cha matenda a bipolar I. Imapezeka ngati piritsi lokamwa. Latuda nthawi zambiri amatengedwa kamodzi patsiku ndi chakudya.
Kodi Limbikitsani?
Abilify ndi mankhwala oletsa antipsychotic omwe amagwiritsidwa ntchito pochiza schizophrenia komanso magawo osakanikirana kapena amisala okhudzana ndi matenda ochititsa munthu kusinthasintha zochitika. Abilify imavomerezedwanso kuthana ndi vuto lalikulu lachisoni, matenda a autistic, ndi matenda a Tourette. Imapezeka ngati piritsi lokamwa, piritsi lowonongeka pakamwa, yankho la m'kamwa, ndi jakisoni. Limbikitsani amatengedwa kamodzi patsiku ndi chakudya kapena popanda chakudya.
Kodi Latuda ndi Abilify ndizofanana?
Onse a Latuda ndi Abilify ndi ma antipsychotic, kapena m'badwo wachiwiri wa ma antipsychotic, ovomerezeka kuchiza schizophrenia. Komabe, amabwera m'mitundu yosiyanasiyana ndipo amakhala ndi mawonekedwe osiyanasiyana kupatula schizophrenia. Latuda amathandizira magawo okhumudwitsa a bipolar I disorder pomwe Amathandizira kuthana ndi manic episodes of bipolar I disorder. Latuda imafunikiranso kupatsidwa chakudya pomwe Abilify itha kuperekedwa kapena wopanda chakudya.
Kodi Latuda kapena Abilify ndiyabwino?
Latuda ndi Abilify onse ndi mankhwala othandiza a schizophrenia ndi matenda ena amisala. Latuda itha kukhala yothandiza monga Kuchepetsa ndi mankhwala ena opatsirana ndi ma psychotic, ndipo atha kuyambitsa zovuta zochepa monga kunenepa . Zinthu zina ziyenera kuganiziridwa posankha Latuda kapena Abilify, monga mtengo. Funsani wothandizira zaumoyo kuti akupatseni chithandizo chabwino kwambiri.
Kodi ndingagwiritse ntchito Latuda kapena Abilify ndili ndi pakati?
Kafukufuku ali ndi malire pakugwiritsa ntchito Latuda ndi Abilify ali ndi pakati. Mankhwalawa antipsychotic amatha kuyambitsa zizindikiro za extrapyramidal kapena kutaya kwa ma neonates m'nthawi yachitatu. Ayenera kumwedwa pokhapokha phindu likaposa chiwopsezo chake. Funsani omwe akukuthandizani kuti akupatseni malangizo azaumoyo kuti mudziwe ngati muyenera kugwiritsa ntchito Latuda kapena Abilify mukakhala ndi pakati.
Kodi ndingagwiritse ntchito Latuda kapena Abilify ndi mowa?
Mankhwala onse oledzeretsa komanso antipsychotic ali ndi vuto lokhumudwitsa lamkati (CNS). Kumwa mankhwala opatsirana pogwiritsira ntchito mankhwala oledzeretsa kungapangitse kuti pakhale zovuta zina, monga kugona ndi chizungulire. Kumwa mowa kuyenera kuchepetsedwa mukamamwa Latuda kapena Abilify.
Kodi Latuda ndikulimbitsa mtima kapena antipsychotic?
Latuda sikuti imakhazikika. M'malo mwake, Latuda ndi mankhwala oletsa antipsychotic omwe atha kuperekedwa limodzi ndi zolimbitsa mtima monga Lithobid (lithium) kapena Depakene (valproic acid) yothandizira kuvutika maganizo. Zitsanzo zina za mankhwala a antipsychotic ndi Invega (paliperidone), Seroquel (quetiapine), Zyprexa (olanzapine), Geodon (ziprasidone), Rexulti (brexpiprazole), ndi Vraylar (cariprazine).
Kodi pali generic ya Latuda?
Latuda generic yavomerezedwa ndi FDA. Komabe, mtundu wa Latuda mwina sungapezekebe pamsika. Opanga ma generic Latuda akuphatikiza Accord Healthcare, Piramal Healthcare UK Limited, ndi Sun Pharmaceutical Industries Ltd.
Kodi chimachitika ndi chiyani ngati simutenga Latuda ndi chakudya?
Latuda mwina sangagwire bwino ntchito akatengedwa wopanda chakudya. Ndikulimbikitsidwa kuti mutenge Latuda ndi chakudya chosachepera 350 ma calories kuti muyamwe bwino. Kuyamwa kwa Latuda kumawonjezeka kawiri pamene mankhwalawa amatengedwa ndi chakudya.
