Losartan vs. lisinopril: Kusiyana, kufanana, ndi zomwe zili zabwino kwa inu
Mankhwala osokoneza bongo Vs. MnzanuKuwunika kwa mankhwala osokoneza bongo & kusiyana kwakukulu | Zinthu zothandizira | Mphamvu | Kuphunzira inshuwaransi ndi kufananiza mtengo | Zotsatira zoyipa | Kuyanjana kwa mankhwala | Machenjezo | FAQ
Ngati ndinu m'modzi mwa anthu aku America okwana 103 miliyoni omwe ali nawo kuthamanga kwa magazi , mwina dokotala wanu adanenapo zakukuyambirani pamankhwala kuti muchepetse kuthamanga kwa magazi. Losartan ndi lisinopril onse ndi mankhwala omwe amagwiritsidwa ntchito pochizira kuthamanga kwa magazi ( matenda oopsa ). Losartan ndi angiotensin II receptor blocker (ARB) ndi lisopril ndi angiotensin-yotembenuza enzyme inhibitor (ACE inhibitor).
Mankhwala onsewa amagwira ntchito mbali ina ya thupi yotchedwa renin-angiotensin system koma m'njira zosiyanasiyana. Mu renin-angiotensin system, ACE inhibitors amaletsa chinthu chotchedwa angiotensin II kuti chisapangidwe. Angiotensin II imachepetsa mitsempha yamagazi ndikuwonjezera kuthamanga kwa magazi, chifukwa chake poletsa kupanga angiotensin II, kuthamanga kwa magazi kumatsika. Ma ARB amaletsa angiotensin II kuti asamangidwe ndi ma receptors, potero amachepetsa kuthamanga kwa magazi.
Kodi pali kusiyana kotani pakati pa losartan ndi lisinopril?
Losartan ndi ARB, yomwe imadziwika ndi dzina la piritsi, monga Cozaar (kapena Hyzaar pophatikiza ndi hydrochlorothiazide, diuretic yomwe imafupikitsidwa ngati HCTZ). Mlingo wokhazikika umakhala pakati pa 25 mg mpaka 100 mg tsiku lililonse.
Lisinopril ndi ACE inhibitor yomwe imapezeka patebulopo ndi maina a Prinivil kapena Zestril (kapena Zestoretic kuphatikiza ndi HCTZ). Ikupezekanso ngati yankho la pakamwa lotchedwa Qbrelis. Mlingo wokhazikika umakhala pakati pa 5 mg mpaka 40 mg tsiku lililonse.
ZOKHUDZA: Zambiri za Losartan | Zambiri za Lisinopril
| Kusiyana kwakukulu pakati pa losartan ndi lisinopril | ||
|---|---|---|
| Losartan | Lisinopril | |
| Gulu la mankhwala osokoneza bongo | Angiotensin receptor blocker (ARB) | Kuletsa kwa ACE |
| Chizindikiro cha Brand / generic | Brand ndi generic | Brand ndi generic |
| Kodi dzina lake ndi ndani? | Cozaar Hyzaar (losartan / HCTZ) | Prinivil Zestril Qbrelis (yankho lamlomo) Zestoretic (lisinopril / HCTZ) |
| Kodi mankhwalawa amabwera mwa mawonekedwe ati? | Piritsi (lokha komanso kuphatikiza ndi HCTZ) | Piritsi (lokha komanso kuphatikiza ndi HCTZ) |
| Kodi mulingo woyenera ndi uti? | 25 mpaka 100 mg tsiku lililonse | 5 mpaka 40 mg tsiku lililonse |
| Kodi mankhwalawa amatenga nthawi yayitali bwanji? | Kutalika | Kutalika |
| Ndani amagwiritsa ntchito mankhwalawa? | Akuluakulu, ana (kutengera mawonekedwe) | Akuluakulu, ana (kutengera mawonekedwe) |
Mukufuna mtengo wabwino kwambiri pa lisinopril?
Lowani zidziwitso zamitengo ya lisinopril kuti mupeze kuti mitengo ikasintha liti!
Pezani zidziwitso zamitengo
Zomwe amathandizidwa ndi losartan vs. lisinopril
Losartan imasonyezedwa pochiza matenda oopsa (HTN), kapena kuthamanga kwa magazi. Amagwiritsidwanso ntchito pochepetsa chiopsezo cha sitiroko kwa odwala omwe ali ndi kuthamanga kwa magazi komanso kumanzere kwa ventricular hypertrophy, ndipo amagwiritsidwanso ntchito pochiza matenda ashuga mwa odwala ena.
Lisinopril imawonetsedwa ngati chithandizo cha HTN, monga chithandizo chothandizira kupunduka kwa mtima, komanso kupititsa patsogolo kupwetekedwa mtima.
Mankhwala onsewa amakhalanso ndi zilembo zosalemba, zomwe zafotokozedwa pansipa.
| Mkhalidwe | Losartan | Lisinopril |
| Chithandizo cha matenda oopsa (HTN) | Inde | Inde |
| Kuchepetsa chiopsezo cha sitiroko kwa odwala omwe ali ndi HTN ndikumanzere kwa ventricular hypertrophy (LVH) | Inde | Kutumiza |
| Chithandizo cha matenda ashuga nephropathy ndi serum creatinine yokwera komanso proteinuria mwa odwala omwe ali ndi matenda ashuga amtundu wa 2 komanso mbiri ya HTN | Inde | Kutumiza |
| Chithandizo chothandizirana pakuwongolera kulephera kwa mtima kwa odwala omwe sakuyankha mokwanira ku diuretics ndi digitalis | Kutumiza | Inde |
| Chithandizo cha odwala okhazikika mthupi mkati mwa maola 24 kuchokera pachimake cha myocardial infarction (MI) kuti apulumuke | Kutumiza | Inde |
| Kulephera kwa mtima ndi gawo lochepetsedwa | Kutumiza | Kutumiza |
| Matenda a Marfan ochepetsa kuchepa kwa aortic dilatation | Kutumiza | Kutumiza |
| Kuwongolera kwa odwala omwe ali ndi ST-elevation acute coronary syndrome | Kutumiza | Kutumiza |
| Olandira impso | Kutumiza | Kutumiza (kwa odwala omwe ali ndi post-transplant erythrocytosis) |
| Odwala omwe ali ndi matenda a impso a proteinuric | Kutumiza (mwa odwala matenda ashuga) | Osalemba (mwa odwala matenda ashuga kapena omwe alibe matenda ashuga) |
| Mitsempha yamitsempha yolimba | Kutumiza | Kutumiza |
Kodi losartan kapena lisinopril ndiyothandiza kwambiri?
Powunikanso maphunziro 61 poyerekeza ma ARB (kuphatikiza losartan) ndi ACE inhibitors (kuphatikiza lisinopril), magulu onse awiriwa amapezeka zotsatira zanthawi yayitali kuthamanga kwa magazi. Olembawo adanenanso kuti magulu onse awiriwa amathandizira kufa, zochitika zamtima, zochitika zazikulu zoyipa, moyo wabwino, ndi zoopsa monga milomo ya lipid, matenda ashuga, ndikusiya kuchuluka kwa ma ventricular ndikugwira ntchito.
Pang'ono kuphunzira Odwala omwe ali ndi matenda a impso, losartan ndi lisinopril adachitanso chimodzimodzi pa impso ndi kuthamanga kwa magazi.
Mankhwala othandiza kwambiri kwa inu ayenera kutsimikiziridwa ndi dokotala wanu, yemwe angayang'ane chithunzi chonse cha matenda anu, mbiri yanu, ndi mankhwala ena omwe mukumwa.
Kuyerekeza ndi kuyerekezera mtengo wa losartan vs. lisinopril
Onse losartan ndi lisinopril amakhala ndi inshuwaransi komanso Medicare Part D mu mawonekedwe achibadwa. Mitundu yamaina amtunduwu itha kulipidwa ndi copay yayikulu. Mtengo wamthumba wamapiritsi 30 a losartan 100 mg ukhoza kuyambira $ 28- $ 70, ndipo Medicare Part D copay ili pafupifupi $ 0- $ 13. Ndi coupon ya SingleCare, mtengo wake ndi $ 9- $ 16 kutengera mankhwala omwe akutenga nawo mbali. Mtengo wamthumba wamapiritsi 30 a lisinopril 10 mg ndi pafupifupi $ 15, ndipo Medicare Part D copay ili pafupifupi $ 0- $ 7. Mutha kusunga ndalama pa lisinopril pogwiritsa ntchito khadi yochotsera ya SingleCare kapena coupon.
Yesani khadi la kuchotsera la SingleCare
| Losartan | Lisinopril | |
| Nthawi zambiri amakhala ndi inshuwaransi? | Inde | Inde |
| Nthawi zambiri amadzazidwa ndi Medicare? | Inde | Inde |
| Mlingo woyenera | # 90, 100 mg mapiritsi | # 90, 20 mg mapiritsi |
| Wopanga Medicare wamba | $ 0- $ 13 | $ 0- $ 7 |
| Mtengo wosakwatiwa | $ 28- $ 70 | $ 9- $ 26 |
Zotsatira zoyipa za losartan vs. lisinopril
Zotsatira zoyipa kwambiri za losartan zimaphatikizapo chifuwa, chizungulire, matenda opuma opuma, kutopa, ndi kutsegula m'mimba.
Zotsatira zoyipa kwambiri za lisinopril zimaphatikizapo chifuwa, chizungulire, kupweteka mutu, kutopa, ndi kutsegula m'mimba.
Zotsatira zina zoyipa zimatha kuchitika. Funsani katswiri wazachipatala kuti mupeze mndandanda wathunthu wazovuta.
| Losartan | Lisinopril | |||
| Zotsatira zoyipa | Zoyenera? | Pafupipafupi | Zoyenera? | Pafupipafupi |
| Tsokomola | Inde | 17-29% | Inde | 3.5-69% |
| Chizungulire | Inde | 3% | Inde | 5.4% |
| Pamwamba kupuma matenda | Inde | 8% | Inde | 2.1% |
| Kuchulukana m'mphuno | Inde | awiri% | Inde | 0.4% |
| Ululu wammbuyo | Inde | awiri% | Ayi | - |
| Kutopa | Inde | > 4% | Inde | 2.5% |
| Kutsekula m'mimba | Inde | > 4% | Inde | 2.7% |
| Nseru | Inde | Osati lipoti | Inde | awiri% |
| Mutu | Inde | Osati lipoti | Inde | 5.7% |
Gwero: DailyMed (losartan) , Tsiku ndi Tsiku (lisinopril)
Kuyanjana kwa mankhwala osokoneza bongo a losartan vs. lisinopril
Losartan kapena lisinopril sayenera kugwiritsidwa ntchito ndi potaziyamu kapena mankhwala ena omwe amachulukitsa potaziyamu (monga potassium-sparing diuretics), chifukwa chowopsa cha hyperkalemia. Kuonjezerapo, funsani dokotala wanu za potaziyamu muzakudya zanu komanso ngati mungapewe zakudya zokhala ndi potaziyamu komanso zotengera mchere zomwe zili ndi potaziyamu.
NSAIDs (nonsteroidal anti-inflammatory drugs) siziyenera kugwiritsidwa ntchito limodzi ndi losartan kapena lisinopril, chifukwa kuphatikiza kungayambitse impso kapena impso kulephera.
Losartan kapena lisinopril sayenera kugwiritsidwa ntchito limodzi ndi ACE inhibitor, ARB, kapena Tekturna (aliskiren) chifukwa kuphatikiza kumawonjezera chiopsezo chotsika magazi, potaziyamu, kukomoka, kuwonongeka kwa impso, kapena impso.
Funsani wothandizira zaumoyo wanu kuti mupeze mndandanda wathunthu wamagwiridwe antchito.
| Mankhwala osokoneza bongo | Gulu la Mankhwala | Losartan | Lisinopril |
| Potaziyamu | Electrolyte | Inde | Inde |
| Midamor (amiloride) Aldactone (spironolactone) Dyrenium (katatu) Inspra (eplerenone) | Mankhwala okhudzana ndi potaziyamu | Inde | Inde |
| Asipilini Kutulutsa Motrin, Advil (ibuprofen) Aleve (dzina loyamba) Makanema (meloxicam) Alireza (alirezakhademi) Pumulirani (nabumetone) | NSAIDs | Inde | Inde |
| Vasotec (enalapril) Lotensin (benazepril) Zowonjezera (quinapril) Altace (ramipril) | Zoletsa za ACE | Inde | Inde |
| Diovan (valsartan) Edarbi Kuukira (candesartan) Avapro (irbesartan) Micardis (telmisartan) Benicar (olmesartan) | Ma ARB | Inde | Inde |
| Tekturna (aliskiren) | Renin choletsa | Inde | Inde |
| Lifiyamu | Wothandizira wa Antimanic | Inde | Inde |
Machenjezo a losartan ndi lisinopril
Losartan ndi lisinopril onse amabwera ndi chenjezo la bokosi, lomwe ndi chenjezo lamphamvu kwambiri monga momwe a FDA amafunira. Mankhwala osokoneza bongo (monga losartan ndi lisinopril) omwe amagwira ntchito ya renin-angiotensin amatha kupweteketsa kwambiri fetus / kupunduka kwa kubadwa kapena kufa ndipo ayenera kutha ukangobereka.
Machenjezo ena omwe amagwiritsidwa ntchito kwa losartan ndi lisinopril:
- Odwala omwe ataya madzi m'thupi kapena amatenga okodzetsa amatha kudwala magazi (hypotension).
- Kusintha kwa ntchito yaimpso, kuphatikizapo kulephera kwakukulu kwa impso, kumatha kuchitika. Chiwopsezo chimakhala chachikulu kwa odwala omwe ali ndi vuto la impso kapena olephera mtima kwambiri. Odwalawa sangakhale osankhidwa ndi ACE inhibitor kapena ARB. Ngati imodzi mwa mankhwalawa yayamba, ntchito ya impso iyenera kuyang'aniridwa.
- Masamba a potaziyamu ayenera kuyang'aniridwa.
Lisinopril ili ndi machenjezo enanso:
- Pali kuthekera kwa kuchitapo kanthu kwa anaphylactic (kukwiya kwambiri), kuphatikiza angioedema (kutupa) kwa nkhope, malekezero, milomo, lilime, glottis, ndi / kapena kholingo. Izi zimatha kuchitika nthawi iliyonse mukamalandira chithandizo. Angioedema yolumikizidwa ndi laryngeal edema itha kupha. Ngati pali lilime, glottis kapena kholingo, zomwe zingayambitse kuyenda kwa ndege, chithandizo chadzidzidzi chimafunika. Lisinopril iyenera kuthetsedwa ngati izi zikuchitika.
- Pali chiopsezo chochepa cha mavuto a chiwindi; michere ya chiwindi iyenera kuyang'aniridwa.
- Chifukwa cha kuwonongeka kwa chinthu chotchedwa bradykinin, chifuwa chouma chimatha kuchitika. Pomwe mankhwala ayimitsidwa, chifuwa chimatha.
Mafunso omwe amafunsidwa pafupipafupi za losartan ndi lisinopril
Kodi losartan ndi chiyani?
Losartan ndi angiotensin receptor blocker yomwe imathandizira kutsitsa kuthamanga kwa magazi. Itha kugwiritsidwanso ntchito pazinthu zina zosiyanasiyana, zomwe zafotokozedwa pamwambapa.
Lisinopril ndi chiyani?
Lisinopril ndi ACE inhibitor yomwe imathandizira kutsitsa magazi. Amagwiritsidwanso ntchito pazinthu zina zamankhwala, zomwe zafotokozedwa pamwambapa.
Kodi losartan vs. lisinopril ndi yomweyo?
Ngakhale mankhwala onsewa amagwiritsa ntchito renin-angiotensin system, imagwira ntchito m'malo osiyanasiyana, koma mankhwala onse amachepetsa kuthamanga kwa magazi ndipo amagwiritsidwa ntchito pamatenda ena amtima kapena impso. Amakhalanso ndi kusiyana kwina pamalingaliro, machenjezo, ndi mtengo.
Zina mwa ACE inhibitors (monga lisinopril) mwina mudamvapo za Lotensin (benazepril), Vasotec (enalapril), Accupril (quinapril), ndi Altace (ramipril).
Ma ARB ena (monga losartan) mwina mudamvapo za Edarbi (azilsartan - palibe generic), Atacand (candesartan), Avapro (irbesartan), Micardis (telmisartan), Diovan (valsartan), ndi Benicar (olmesartan).
Kodi losartan kapena lisinopril ndibwino?
Kafukufuku wasonyeza ma ARB ngati losartan ndi ACE inhibitors ngati lisinopril kukhala ndi zovuta zofananira. Funsani wothandizira zaumoyo wanu kuti muwone ngati imodzi mwa mankhwalawa ndi yoyenera kwa inu.
Kodi ndingagwiritse ntchito losartan kapena lisinopril ndili ndi pakati?
Losartan kapena lisinopril sayenera kumwedwa ali ndi pakati. Mankhwala onsewa ndi owopsa kwa mwana wosabadwa ndipo amatha kuyambitsa zofooka zazikulu kapena kupha kumene. Ngati mukumwa kale losartan kapena lisinopril ndikupeza kuti muli ndi pakati, pitani kuchipatala nthawi yomweyo.
Kodi ndingagwiritse ntchito losartan kapena lisinopril ndi mowa?
Kumwa mowa mutatenga losartan kapena lisinopril kumatha kukulitsa chizungulire, kapena kusokoneza kuthamanga kwa magazi kapena matenda ena. Funsani dokotala wanu za kumwa mowa ndi losartan kapena lisinopril.
Kodi ndiyenera kutenga lisinopril ndi losartan limodzi?
Ayi. Ngakhale mankhwala ena amagazi amagwiritsidwa ntchito limodzi (monga losartan kapena lisinopril kuphatikiza ndi diuretic), lisinopril ndi losartan siziyenera kutengedwa limodzi. Kuchita izi kumawonjezera chiopsezo chotsika magazi, potaziyamu, komanso kuvulala kwa impso, zomwe zitha kukhala zowopsa kapenanso kupha.
Kodi losartan ndi ACE inhibitor kapena beta blocker?
Losartan ndi angiotensin receptor blocker. Si choletsa cha ACE kapena beta blocker.
Kodi losartan imayambitsa zovuta zochepa kuposa lisinopril?
Mankhwala onsewa amakhala ndi zovuta zina, ngakhale lisinopril imatha kuyambitsa chifuwa chowuma ndipo imatha kutenga angioedema (kukwiya kwambiri). Funsani akatswiri azachipatala anu kuti muwone mndandanda wazomwe zingachitike.
