Phenylephrine vs. pseudoephedrine: Kusiyana, kufanana, ndi zomwe zili zabwino kwa inu
Mankhwala osokoneza bongo Vs. MnzanuKuwunika kwa mankhwala osokoneza bongo & kusiyana kwakukulu | Zinthu zothandizira | Mphamvu | Kuphunzira inshuwaransi ndikufanizira mtengo | Zotsatira zoyipa | Kuyanjana kwa mankhwala | Machenjezo | FAQ
Pali zifukwa zambiri zomwe zimapangitsa kuti mphuno zisokonezeke komanso kupsyinjika kwa sinus, makamaka nyengo ya matendawo rhinitis ndi chimfine. Kuthamanga kwa mphuno ndi sinus kumatha kusokoneza kupuma kwammphuno, kumabweretsa mutu, ndikuchepetsa zokolola. Phenylephrine (Sudafed PE) ndi pseudoephedrine (Sudafed) ndi mitundu iwiri ya mankhwala opangira mankhwala omwe angakhale othandiza kuti athetse vuto la sinus. Mankhwalawa amagwira ntchito polimbikitsa mwachindunji ma adrenergic receptors m'mphuno, komanso ziwalo zina za thupi. Ngakhale ndizofanana m'njira zina, pali zosiyana zazikulu zomwe zingatsimikizire kuti ndi yani yabwino kwambiri kwa inu.
Kodi pali kusiyana kotani pakati pa phenylephrine ndi pseudoephedrine?
Phenylephrine (Phenylephrine ndi chiyani?) Ndi mankhwala opumulira m'mphuno omwe amapezeka mwa iwo okha kapena m'njira zosiyanasiyana zophatikizira chimfine ndi chimfine. Ikupezeka pa kauntala (OTC), ndipo sikutanthauza mankhwala kapena mitengo yazogula. Phenylephrine ndi wamphamvu kwambiri wa alpha-adrenergic agonist ndipo alibe zochitika za beta-adrenergic agonist. Alpha-adrenergic receptors, ikalimbikitsidwa, imayambitsa kupindika kwa mitsempha yamagazi. Beta-adrenergic receptors, ikalimbikitsidwa, imathandizira kupumula kwa mitsempha yamagazi, komanso kumawonjezera kugunda kwa mtima. Ngakhale zimayambitsa vasoconstriction ina m'mphuno yomwe ingachepetse kuthamanga kwa sinus, imayambitsanso vasoconstriction mthupi lonse lomwe lingakulitse kuthamanga kwa magazi. Phenylephrine imapezeka pakamwa pakamwa ngati piritsi kapena madzi, komanso yankho la jakisoni. Njira yothetsera jakisoni imangoperekedwera m'malo azachipatala.
Pseudoephedrine (Pseudoephedrine ndi chiyani?) Ndi mankhwala opumulira m'mphuno omwe amapezekanso pawokha kapena m'njira zosiyanasiyana zophatikizira chimfine ndi chimfine. Amapezeka popanda mankhwala, koma kugula kwake kumangokhala pamiyeso yosiyanasiyana. Dera lililonse, kuphatikiza malangizo aboma, limasankha malire ogulira ogula. Kugula kwa pseudoephedrine kuyenera kuchitika ku malo osungira mankhwala ndi wamankhwala omwe alipo ndipo amalowetsedwa mu database. Malamulowa tsopano alipo chifukwa pseudoephedrine ndichofunikira kwambiri pakupanga methamphetamine.
Pseudoephedrine imapangitsa kuti alpha-adrenergic receptors mu nasal mucosa, komanso zolandilira za beta-adrenergic mthupi lonse. Izi zimabweretsa kudzilimbitsa kwammphuno komanso kupumula kwaminyewa, komanso kumawonjezera kugunda kwa mtima komanso kugunda. Amapezeka pokonzekera pakamwa ngati piritsi kapena madzi, komanso yankho la jakisoni. Njira yothetsera jakisoni imangoperekedwera m'malo azachipatala.
| Kusiyana kwakukulu pakati pa phenylephrine ndi pseudoephedrine | ||
|---|---|---|
| Phenylephrine | Pseudoephedrine | |
| Gulu la mankhwala osokoneza bongo | Al-adrenergic agonist | Alpha-adrenergic ndi beta-adrenergic agonist |
| Chizindikiro cha Brand / generic | Mtundu wopezeka komanso generic | Mtundu wopezeka komanso generic |
| Kodi dzina lake ndi ndani? | Kusokonezeka PE | Atasokonezeka |
| Kodi mankhwalawa amabwera mwa mawonekedwe ati? | Piritsi lotulutsira pomwepo, madzi amkamwa | Piritsi lotulutsira nthawi yomweyo, piritsi lotalikitsa, zakumwa zam'kamwa |
| Kodi mulingo woyenera ndi uti? | 10 mg maola 4 aliwonse | 60 mg maola 4 kapena 6 aliwonse |
| Kodi mankhwalawa amatenga nthawi yayitali bwanji? | Nthawi yayitali mpaka kupumula kwa chizindikiritso | Nthawi yayitali mpaka kupumula kwa chizindikiritso |
| Ndani amagwiritsa ntchito mankhwalawa? | Ana azaka 12 kapena kupitirira, akulu | Ana azaka 4 kapena kupitirira, akulu |
Zomwe zimathandizidwa ndi phenylephrine vs. pseudoephedrine
Pali mtundu wa jakisoni wa phenylephrine wovomerezeka wothandizira hypotension, kapena kutsika kwambiri kwa magazi, munthawi yokhudzana ndi mantha kapena anesthesia. Mankhwalawa amaperekedwa ngati jekeseni m'malo azachipatala pomwe wodwala akuyang'aniridwa ndi dokotala komanso othandizira ena. Amagwiritsidwanso ntchito ngati chizindikiro, popanda kuvomerezedwa ndi FDA, kuchiza ischemic priapism (kukonzekera amuna omwe atenga nthawi yayitali kwambiri). Fomu ya phenylephrine yogwiritsidwa ntchito mosagwiritsidwa ntchito imagwiritsidwa ntchito ngati mankhwala osokoneza bongo m'mphuno.
Pseudoephedrine imavomerezedwa kuti ichiritse mphuno.
| Mkhalidwe | Phenylephrine | Pseudoephedrine |
| Kutengeka | Inde | Ayi |
| Kusagwirizana ndi Ischemic | Kutumiza | Ayi |
| Kuchulukana m'mphuno | Inde | Inde |
Kodi phenylephrine kapena pseudoephedrine ndiyothandiza kwambiri?
Nthawi ina, pseudoephedrine ndiye anali yekhayo wotsukira m'mimbamo pamsika. Komabe, malonda a mankhwalawa atayamba kuletsedwa, opanga amayang'ana kuti asinthe zomwe akupanga ndi chinthu china chogwirira ntchito kuti athe kukhalabe m'mashelufu amasitolo ndi kugula mosavuta. Phenylephrine ndiye adakhala wothira pakamwa wopezeka m'mankhwala omwe atha kugulidwa osapitanso kumalo ogulitsira mankhwala kuti mugulitse mankhwala anu.
Kugwiritsa ntchito kwambiri kwa phenylephrine kunalimbikitsa ofufuza kuti awone ngati zovuta zake zowopsa zinali zamphamvu ngati za pseudoephedrine. Mowongoleredwa mwachisawawa kuphunzira , odwala omwe ali ndi vuto lodana ndi rhinitis amakumana ndi mungu wochokera ku Vienna Challenge Chamber. Adalandira mwina phenylephrine, pseudoephedrine, kapena placebo kuti achepetse matendawa. Kafukufukuyu adatsimikiza kuti panalibe kusiyana kwakukulu pakati pa phenylephrine ndi placebo. Komabe, pseudoephedrine idapereka kusiyana kwakukulu pakudziyesa kwammphuno poyerekeza ndi placebo ndi phenylephrine. Zotsatirazi zikuwonetsa kuti pseudoephedrine ndiye wodziletsa kwambiri wammphuno.
Ofufuza ena atero anasonyeza nkhawa kuti chikhumbo chathu chochepetsa kupanga methamphetamine poletsa kugulitsa kwa pseudoephedrine kwapangitsa kuti chinthu chotsika (phenylephrine) chigwiritsidwe ntchito m'malo mwake.
Nthawi zambiri, chithandizo cha rhinitis ndi sinus pressure zitha kukhala zothandiza ngati othandizira ena agwiritsidwa ntchito limodzi. Mwachitsanzo, ma antihistamine amachedwetsa kupanga ntchofu ndipo imatha kukulitsa zovuta zamankhwala osokoneza bongo.
Kuphunzira ndi kuyerekezera mtengo wa phenylephrine vs. pseudoephedrine
Phenylephrine pakamwa pake, pa-pepala safuna mankhwala. Sichikuphimbidwa ndi Medicare kapena mapulani ena a inshuwaransi yamalonda. Mtengo wapakati pa Sudafed PE ndi pafupifupi $ 6- $ 8 mukagula pa kontrakitala, koma ngati dokotala atalemba mankhwala, mutha kudzaza ku pharmacy yotsika $ 5.96 ndi coupon yochokera ku SingleCare.
Pseudoephedrine, ngakhale imangoletsedwa kugula ku pharmacy, imakhalanso mankhwala a OTC. Ngati dokotala angalembere mankhwala a pseudoephedrine, mudzatha kupeza kuchuluka komwe angakupatseni ngakhale atakhala okwera kuposa malire aboma oti mugule pa intaneti.
Pseudoephedrine sikuti imaphimbidwa ndi Medicare kapena mapulani ena a inshuwaransi yamalonda, ngakhale ochepa atha kulembedwa ngati mankhwala alembedwa. Mtengo wapakati wamapiritsi 24 a Sudafed 30 mg amakhala pakati pa $ 6- $ 10 mukagula pa-counter Ngati dokotala akulemberani mankhwala, mutha kudzaza generic ku pharmacy yotsika $ 2.53 ndi coupon yochokera ku SingleCare .
| Phenylephrine | Pseudoephedrine | |
| Nthawi zambiri amakhala ndi inshuwaransi? | Ayi | Ayi |
| Nthawi zambiri amakhala ndi Medicare? | Ayi | Ayi |
| Mlingo woyenera | 18, 10 mg mapiritsi | 24, 30 mg mapiritsi |
| Wopanga Medicare wamba | n / A | n / A |
| Mtengo wosakwatiwa | $ 6 + | $ 2- $ 5 |
Pezani khadi yotsitsa ya SingleCare
Zotsatira zoyipa za phenylephrine vs. pseudoephedrine
Phenylephrine ndi pseudoephedrine onse ndi adrenergic agonists ndipo ali ndi zovuta zina zoyipa, ngakhale kusiyana kwawo pakugwirizana kwa alpha- ndi beta-adrenergic receptors kumayambitsa zovuta zina.
Phenylephrine ndi pseudoephedrine amadziwika kuti amachititsa nkhawa, chizungulire, kupweteka mutu, kugona tulo, mantha, komanso kupumula. Kuphatikiza apo, pseudoephedrine idalembedwa kuti imayambitsa tachycardia, palpitations, arrhythmia, kusawona bwino, ndi anorexia. N'zovuta kufotokoza kuti zotsatirazi zimachitika kangati.
Odwala omwe ali ndi kuthamanga kwa magazi kapena zina zodziwika bwino zamtima sayenera kugwiritsa ntchito pseudoephedrine popanda chitsogozo kuchokera kwa dokotala wawo.
Tebulo lotsatirali siliyenera kukhala mndandanda wathunthu wazovuta. Muyenera kufunsa wamankhwala kapena akatswiri azaumoyo kuti mumve mndandanda wonse.
| Phenylephrine | Pseudoephedrine | |||
| Zotsatira zoyipa | Zoyenera? | Pafupipafupi | Zoyenera? | Pafupipafupi |
| Kuda nkhawa | Inde | Osatanthauziridwa | Inde | Osatanthauziridwa |
| Chizungulire | Inde | Osatanthauziridwa | Inde | Osatanthauziridwa |
| Mutu | Inde | Osatanthauziridwa | Inde | Osatanthauziridwa |
| Kusowa tulo | Inde | Osatanthauziridwa | Inde | Osatanthauziridwa |
| Mantha | Inde | Osatanthauziridwa | Inde | Osatanthauziridwa |
| Kusakhazikika | Inde | Osatanthauziridwa | Inde | Osatanthauziridwa |
| Tachycardia | Ayi | Osatanthauziridwa | Inde | Osatanthauziridwa |
| Kupindika | Ayi | Osatanthauziridwa | Inde | Osatanthauziridwa |
| Makhalidwe amtima | Ayi | Osatanthauziridwa | Inde | Osatanthauziridwa |
| Masomphenya olakwika | Ayi | Osatanthauziridwa | Inde | Osatanthauziridwa |
| Anorexy | Ayi | Osatanthauziridwa | Inde | Osatanthauziridwa |
Gwero Tsiku ndi Tsiku (phenylephrine) Tsiku ndi Tsiku (pseudoephedrine)
Kuyanjana kwa mankhwala a phenylephrine vs. pseudoephedrine
Phenylephrine ndi pseudoephedrine ali ndi mbiri yofananira yolumikizana ndi mankhwala chifukwa cha zovuta zawo pa alpha ndi beta receptors. Alpha-blockers, monga tamsulosin, atha kuchepetsa mphamvu za vasoconstrictive zamadzimadzi onse omwe amawapangitsa kukhala osagwira ntchito.
MAO inhibitors, monga selegiline, ndi zotengera za ergot, monga bromocriptine, zitha kupititsa patsogolo zotsatira zowopsa za ma decongestant. Izi zitha kukhala zokhudzana ndi munthu yemwe ali ndi matenda oopsa omwe angaganizirepo zogwiritsa ntchito kwambiri. Kuphatikiza kwa phenylephrine kapena pseudoephedrine yokhala ndi MAO inhibitors kapena zotengera za ergot kumatsutsana.
Mndandanda wotsatirawu suyenera kukhala mndandanda wathunthu wazogwirizana ndi mankhwala. Chonde funsani wamankhwala kapena dokotala wanu kuti mumve mndandanda wathunthu komanso zambiri.
| Mankhwala osokoneza bongo | Gulu la Mankhwala | Phenylephrine | Pseudoephedrine |
| Alfuzosin Doxazosin Terazosin Tamsulosin | Alpha-1 otchinga | Inde | Inde |
| Chosema Zolemba Nadolol | Oletsa Beta | Inde | Inde |
| Selegiline Phenelzine | Mao zoletsa | Inde | Inde |
| Ergotamine Bromocriptine | Ma alkaloid opunduka | Inde | Inde |
| Methyldopa Onaninso | Zotsutsana | Inde | Inde |
| Atomoxetine | Kusankha norepinephrine reuptake inhibitors | Inde | Inde |
| Amitriptyline Clomipramine Doxepin Mzere wa Nortriptyline | Tricyclic antidepressants | Inde | Inde |
Machenjezo a phenylephrine vs. pseudoephedrine
Phenylephrine ndi pseudoephedrine amapezeka popanda mankhwala ndipo nthawi zambiri amadziwika kuti ndi mankhwala otetezeka. Chifukwa cha zomwe zimakhudza mtima wamtima, odwala omwe ali ndi kuthamanga kwa magazi ndi matenda amtima sayenera kugwiritsa ntchito mankhwalawa popanda chilolezo chochokera kwa dokotala wawo. Mankhwalawa amapangidwa kuti agwiritsidwe ntchito kwakanthawi kuti athetse vuto la rhinitis komanso kuthamanga kwa sinus. Odwala omwe amakhala ndi zodabwitsazi kwa masiku opitilira asanu ndi awiri, kapena omwe amakhala ndi malungo, ayenera kufunsa dokotala.
Phenylephrine ili mkati gulu la mimba C zomwe zikutanthauza kuti kafukufuku wazinyama adawonetsa zovuta kwa mwana wosabadwayo. Mankhwala akakhala m'gulu C, pakhoza kukhala nthawi zina pomwe phindu kwa wodwala wapakati limaposa chiopsezo, ndipo phenylephrine sayenera kugwiritsidwa ntchito popanda chilolezo kuchokera kwa dokotala wanu. Pseudoephedrine ndi gawo la mimba B lomwe limatanthauza kuti maphunziro azinyama sanawonetse mavuto kwa mwana wosabadwayo. Pseudoephedrine amaonedwa kuti ndi wotetezeka mukamatenga pakati mukatha kufunsa dokotala. Pseudoephedrine iyenera kupewedwa mu trimester yoyamba.
Mafunso omwe amafunsidwa pafupipafupi za phenylephrine ndi pseudoephedrine
Kodi phenylephrine ndi chiyani?
Phenylephrine ndi mankhwala osokoneza bongo amphongo omwe amapezeka m'mapiritsi a 5 mg ndi 10 mg, komanso yankho la m'kamwa. Ikupezekanso mu mawonekedwe ojambulidwa omwe amangogwiritsidwa ntchito m'malo opatsirana ndi akatswiri azachipatala chifukwa chotsika magazi. Phenylephrine itha kugulidwa popanda choletsa kapena kudula mitengo pazomwe wogula akufuna.
Kodi pseudoephedrine ndi chiyani?
Pseudoephedrine ndi mankhwala osokoneza bongo amphongo omwe amapezeka m'mapiritsi a 30 mg ndi 60 mg, komanso mapiritsi otulutsa 120 mg ndi 240 mg. Ikupezekanso ngati yankho lamlomo. Zogula za pseudoephedrine ziyenera kuchitika ku pharmacy ndipo zidziwitso zogula ziyenera kulowetsedwa mu database. Malire a kugula amakhazikitsidwa ndi malangizo aboma ndi mabungwe.
Kodi phenylephrine kapena pseudoephedrine ndi ofanana?
Phenylephrine ndi pseudoephedrine onse ndi adrenergic agonists. Phenylephrine imagwirizana kwambiri ndi ma alpha-adrenergic receptors, pomwe pseudoephedrine imagwirizana ndi alpha- ndi beta-adrenergic receptors. Mbiri zawo zoyipa zimakhala zofanana.
Kodi phenylephrine kapena pseudoephedrine ndibwino?
Kafukufuku wasonyeza kuti pseudoephedrine ndichithandizo chothandiza kwambiri kuposa phenylephrine. Zotsatira zakuthambo za Phenylephrine sizingakhale zosiyana kwambiri ndi za placebo. Zotsatira za mankhwala onsewa zitha kuwonjezeredwa ndikugwiritsa ntchito mankhwala ena omwe amakhudza rhinitis, monga antihistamines.
Kodi ndingagwiritse ntchito phenylephrine kapena pseudoephedrine ndili ndi pakati?
Phenylephrine sayenera kugwiritsidwa ntchito ali ndi pakati pokhapokha phindu kwa mayi liposa chiopsezo. Pseudoephedrine amaonedwa kuti ndiwotetezeka pambuyo pa trimester yoyamba. Nthawi zonse funsani dokotala musanatenge mankhwala opatsirana m'mphuno mukakhala ndi pakati.
Kodi ndingagwiritse ntchito phenylephrine kapena pseudoephedrine ndi mowa?
Phenylephrine ndi pseudoephedrine ndi abwino kumwa ngati mukumwa mowa.
Kodi phenylephrine ndi yolimbikitsa?
Phenylephrine imalimbikitsa ma alpha-adrenergic receptors omwe amatha kuyipangitsa kukhala ndi vuto pakukhudzidwa kwamanjenje monga kusakhazikika, nkhawa, ndi kugona tulo. Amaganiziridwa kuti sizingayambitse zotsatirapo za pseudoephedrine, komabe.
Ndani sayenera kutenga phenylephrine?
Odwala omwe ali ndi kuthamanga kwa magazi, matenda amtima omwe analipo kale, kapena matenda ena amtima sayenera kumwa phenylephrine popanda chilolezo kwa dokotala wawo. Pali njira zina zotsalira, monga kupopera mphuno, komwe kungakhale koyenera m'derali. Amayi omwe ali ndi pakati ayenera kukaonana ndi dokotala asanagwiritse ntchito phenylephrine.
Kodi phenylephrine ndiwongolerazo wabwino?
Kafukufuku wasonyeza kuti phenylephrine ndiwotsika, kapena wosagwira ntchito, wotsika kwambiri kuposa pseudoephedrine. M'malo mwake, sichingakupatseni phindu lililonse kuposa malowa.
