Topamax yochepetsera kunenepa: Onani zambiri zachitetezo ndi magwiridwe antchito

Zambiri Zamankhwala

Topamax ndilo dzina la mankhwala achibadwa otchedwa topiramate . Amadziwika kuti ndi anticonvulsant yomwe imagwiritsidwa ntchito pochiza matenda ngati khunyu, koma imagwiritsidwanso ntchito poyang'anira zinthu zina monga migraine ndi matenda ochititsa munthu kusinthasintha zochitika. Topamax ndiyabwino pochiza zinthu ngati izi, koma anthu ambiri omwe amamwa mankhwalawa amachepetsa kuchepa ngati gawo lalikulu. Tiyeni tiwone mozama momwe Topamax ilili yotetezeka komanso yothandiza komanso momwe ikugwirizanirana ndi kuchepa kwa thupi.

Topamax kuwonda

Topamax imavomerezedwa ndi Food and Drug Administration (FDA) kuti ichiritse khunyu ndikupewa mutu waching'alang'ala , koma mankhwala akuchipatala amadziwikanso chifukwa chochepetsa thupi. Ngakhale kuchepa thupi kungakhale phindu labwino potenga Topamax, a FDA sanavomereze kuti muchepetse thupi lokha.

Topamax imayambitsa kuonda chifukwa imakhudza njala. Anthu omwe amawadya ndikukhala ndi njala yocheperako amatha kumva njala pafupipafupi ndikudya zochepa chifukwa cha izi. Maphunziro asonyeza kuti Topamax amathanso kufulumizitsa kagayidwe, zomwe zikutanthauza kuti thupi limatentha ma calories mwachangu.

Mayesero azachipatala awonetsa izi pafupifupi 6% -17% mwa anthu omwe amatenga Topamax adzakumana ndi kuchepa kwa thupi, ndipo ngakhale anthu ambiri atha kuwona izi ngati phindu lowonjezera, kutaya thupi kwambiri sichinthu chabwino. Anthu ambiri ataya kuchepa thupi kuchokera ku Topamax, atero a Kuldeep Singh, MD, omwe ndi dokotala wochita masewera olimbitsa thupi m'dera la Baltimore komanso director of the Maryland Bariatric Center ku Mercy Medical Center. Kuchepetsa thupi mwachangu kumatha kukhala kosavulaza-itha kukhala nthawi yoti muone dokotala ngati mukumwa Topamax ndipo izi zimakuchitikirani. Kukhala ndi kulemera koyenera ndikofunikira, ndipo njira yabwino yodziwira kulemera kwake ndikofunika kufunsa omwe amakupatsani zaumoyo. Kugwera pansi pa thupi lanu chifukwa cha Topamax kungakhale chizindikiro china kuti ndi nthawi yolankhula ndi omwe amakupatsani.

Kodi ndibwino kutenga Topamax kuti muchepetse kunenepa?

Nthawi zina Topamax imatha kutumizidwa kuti ichotse chizindikiro kuti athandize wina kuchepetsa thupi. Kulemba pamakalata kumachitika pamene dokotala amulembera munthu wina mankhwala omwe amalandiridwa ndi FDA kuti athetse vuto losiyana ndi lomwe wodwala ali nalo. Izi ndizovomerezeka ndipo zimachitika pafupipafupi m'makampani azachipatala, pafupifupi 1 mwa 5 malamulo omwe amalembedwa kuti asachotsedwe.

Dokotala angasankhe kulembera munthu mankhwala a Topamax kuti amuthandize kuchepa thupi kapena kuthana ndi zovuta zakudya monga kubetcha ndi kuyeretsa komwe kumabweretsa kunenepa. Malinga ndi Dr. Singh, wina ayenera kukhala ndi index ya body mass (BMI) yomwe ndi 30 kapena kupitilira apo kuti apatsidwe mankhwala aliwonse ochepetsa thupi, kuphatikiza Topamax.

Kafukufuku wasonyeza kuti anthu omwe amatenga Topamax kuti achepetse kunenepa amataya pafupifupi 11 mapaundi poyerekeza ndi magulu a placebo ngati atamwa mankhwalawa kwa miyezi yosachepera inayi, komanso kuti kuchepa kwa thupi kwa Topamax kumawonjezeka ndi nthawi yonse yamankhwala ndi kuchuluka kwake. Kafukufuku akuwonetsanso kuti chithandizo cha topiramate chitha kuwonjezera mwayi wowerengera kwambiri kuposa kasanu ndi kamodzi .

Ngakhale kuti Topamax ikhoza kukhala yothandiza kwambiri pochepetsa thupi, siyabwino kwa aliyense. Magulu otsatirawa akuyenera kukambirana ndi adotolo asanatenge Topamax chifukwa atha kukhala ndi chiwopsezo chokumana ndi zovuta ngati atenga:

• Anthu omwe ali ndi matenda a impso
• Anthu omwe ali ndi matenda am'mapapo kapena kupuma
• Anthu omwe ali ndi matenda a chiwindi
• Anthu omwe ali ndi mavuto amaso monga glaucoma
• Anthu omwe ali ndi nkhawa
• Anthu omwe ali ndi malingaliro ofuna kudzipha kapena machitidwe
• Anthu omwe ali ndi matenda otupa mafupa
• Anthu omwe ali ndi kagayidwe ketoacidosis

Zitha kukhala zotetezeka kuti amayi apakati atenge Topamax ngati phindu lakumwa mankhwala likuposa chiwopsezo chake. Sizingatheke kuti Topamax iyenera kapena iyenera kuperekedwa ngati ali ndi pakati kuti muchepetse kunenepa. Topamax itha kubweretsa vuto la fetus komanso vuto la kubereka pakamwa ngati atengedwa ndi amayi apakati, ndichifukwa chake amapatsidwa mosamala komanso pokhapokha pakakhala zofunikira zamankhwala. Amatulutsanso mkaka wamunthu, koma sizikudziwika ngati zingakhudze ana oyamwitsa kapena ayi. Topamax ikhoza kupanga mapiritsi oletsa kubereka kukhala osagwira ntchito, choncho ndikofunikira kuti mukambirane ndi dokotala wanu za kugwiritsa ntchito njira zosagwiritsira ntchito mahomoni ngati simukufuna kutenga pakati mukamamwa Topamax.

Anthu omwe alibe mimba komanso omwe alibe matenda aliwonse omwe atchulidwa pamwambapa amatha kutenga Topamax bwinobwino, komabe atha kukhala ndi zovuta chifukwa chomutenga. Nazi zina mwazovuta zoyipa za Topamax pambali pa kuchepa thupi:

• Chizungulire
• Kutopa
• Kunjenjemera
• Kutsekula m'mimba
• Kutaya njala
• Kutaya kwa mgwirizano
• Paresthesia (zotentha)

Ngakhale ndizosowa, Topamax imatha kuyambitsa zovuta zina zomwe zimafunikira chithandizo chamankhwala monga chisokonezo, zovuta zokumbukira, zovuta zowunikira, komanso zovuta kuyankhula. Anthu ena amakhalanso ndi zovuta zam'maganizo monga kukhumudwa, mantha, kusintha kwa malingaliro, komanso malingaliro ofuna kudzipha kapena machitidwe awo. Ngati muli ndi zina mwazizindikirozi muyenera kupeza upezedwe kuchipatala mwachangu.

Zotsatira zina zosowa za Topamax ndi mavuto amaso omwe angayambitse kusintha kwa masomphenya ndi khungu, ndichifukwa chake ndikofunikira kuyimbira dokotala ngati masomphenya anu ayamba kusintha. Mndandanda wazotsatira zake sizokwanira; ngati mungafune mndandanda wathunthu wa zovuta za Topamax funsani dokotala kapena wamankhwala kuti akuwongolereni mankhwala.

Ngati Topamax ikuyambitsa zovuta zambiri, dziwani kuti muli ndi zosankha zina. Chogwiritsira ntchito ku Topamax, topiramate, ndichonso chinthu chofunikira kwambiri pakuchepetsa mankhwala Maganizo , amene ali osakaniza munali fentamini. Malinga ndi Dr. Singh, Qsymia ndi imodzi mwamankhwala abwino kugwiritsa ntchito nthawi yayitali kuphatikiza zakudya ndi kusintha kwa moyo kuti muchepetse kunenepa, makamaka kwa odwala onenepa kwambiri omwe ali ndi kalasi yoyamba 1 kapena kalasi yachiwiri. Kotero ngati simungathe kutenga Topamax chifukwa cha vuto la thanzi kapena chifukwa chakuti mukukumana ndi zovuta zambiri, mungayesere kufunsa wothandizira zaumoyo wanu za Qsymia kapena njira zina zochepetsera thupi.

Momwe mungatengere Topamax kuti muchepetse kunenepa

Topamax ikhoza kutengedwa kuti ikulimbikitse kuchepa kwa thupi ndikuthandizira kuwongolera kutsuka ndi kuyeretsa, koma ndikofunikira kukumbukira kuti sikulowa m'malo popita kwa dokotala ndikupanga dongosolo lokwanira lochepetsa thupi. Ngati mukufuna kutenga Topamax ndibwino kuti mupange msonkhano ndi dokotala wanu kuti muwone ngati zili zoyenera kwa inu. Dokotala wanu amayeza kwathunthu ndikufunsani za mbiri yanu yamankhwala. Ngati inu ndi dokotala mukuganiza kuti Topamax ikhoza kukuthandizani kuti muchepetse thupi, ndiye kuti mutha kulandira mankhwala.

Ngati mungalandire mankhwala kuchokera kwa dokotala, ndikofunikira kudziwa momwe mungatengere Topamax kuti mupeze zotsatira zabwino. Mlingo woyambira wa Topamax wochepetsera kunenepa ndi mlingo wochepa wa 25 mg patsiku, koma mphamvu yamiyeso iyi imatha kuwonjezeka pazochitika ndi zochitika kutengera mbiri yazachipatala ya munthu aliyense komanso kulemera kwake komwe ayenera kutaya.

Kafukufuku wochitidwa ndi Zolemba pa Clinical Psychiatry , Bipolar ndi schizophrenic odwala omwe amapatsidwa pafupifupi 195 mg wa topiramate patsiku adataya pafupifupi mapaundi 22 pakapita nthawi. Izi zikuwonetsa kuti kuchuluka kwa miyezo ya Topamax kumatha kusiyanasiyana kuyambira kutsika mpaka kukwera, ndikuti madotolo amatha kukulitsa kapena kuchepetsa kuchuluka kwa Topamax komwe munthu amatenga kutengera zotsatira zake pakapita nthawi.

Zitha kutenga nthawi kuti muwone zotsatira zakuchepa kwakutenga Topamax. Anthu ena sangawone kusiyana mpaka atamwa mankhwalawa kwa pafupifupi miyezi inayi , pomwe anthu ena atha kuyamba kuchepa m'mwezi wawo woyamba atamwa. Kuchepetsa thupi chifukwa cha topiramate ndi kutsimikiziridwa kuwonjezera pakapita nthawi.

Topamax imatha kumwedwa popanda chakudya ndipo imamwa nthawi yomweyo tsiku lililonse. Sitiyenera kumwa nthawi yofanana ndi mankhwala ena chifukwa cha kuthekera kogwirizana ndi mankhwala. Nawu mndandanda wa mankhwala Topamax sayenera kumwedwa ndi:

• Mankhwala oletsa khunyu
• Mpweya wa anhydrase inhibitors
• Zokhumudwitsa za CNS
• Njira zolera zapakamwa
• Hydrochlorothiazide (HCTZ)
• Pioglitazone
• Lifiyamu
• Amitriptyline

Kuphatikiza pa mankhwalawa, Topamax sayenera kumwa ndi mowa chifukwa izi zimatha kuyambitsa tulo, zimawonjezera chiopsezo chopeza miyala ya impso, ndikuyambitsa kagayidwe kachakudya acidosis . Metabolic acidosis ndimkhalidwe womwe asidi ochulukirachulukira amakhala m'madzi amthupi, ndipo amatha kukhala owopsa ngati atapanda kuchiritsidwa. Mukayamba kupuma mwachangu, kusokonezeka, kutopa kwambiri, komanso kuwonjezeka kwa mtima mukamamwa Topamax, muyenera kupita kuchipatala mwachangu chifukwa izi ndi zizindikilo zoti mungakhale ndi kagayidwe kachakudya acidosis.

Kulemera pambuyo pa Topamax

Wina akasiya kumwa Topamax, ndizotheka kuti atha kukhala onenepa pakapita nthawi, makamaka ngati sanaphatikizepo Topamax ndi kusintha kwa moyo wathanzi. Pakafukufuku wowunika wochitidwa ndi Laibulale ya Zaumoyo Yadziko Lonse , kusiya kwa Topamax kwa miyezi yosachepera isanu ndi umodzi kunawonetsa njira yobwerera kulemera koyambira. Chifukwa chake anthu atha kubwereranso pazomwe amayeza asanayambe kumwa Topamax, koma izi zitha kutenga nthawi.

Kubwereranso kulemera koyambira kumatha kuchitika chifukwa thupi silikukhalanso ndi njala yocheperako komanso kuchepa kwamphamvu kwama metabolism. Njira yabwino yotsimikiziranso kuti mutha kuchepetsa kulemera mutasiya Topamax ndikumasintha moyo wathanzi womwe ungakuthandizeni paulendo wanu wochepetsa thupi.

Njira 5 zotetezera kuonda

Topamax ikhoza kukhala yothandiza paulendo wanu wochepetsa thupi ngati dokotala akuvomereza, koma si njira yokhayo yochepetsera thupi. Kusintha kwa moyo wanu kumatha kukuthandizani kuti muchepetse thupi ndikuzisunga kuti musangalale ndi kuchepa thupi musanatenge Topamax, mukamamwa, kapena mutamwa. Nazi zina mwa njira zabwino kwambiri zochepetsera thupi.

1. Muzidya bwino

Kudya wathanzi ndi imodzi mwanjira zabwino kwambiri komanso zabwino kwambiri zochepetsera thupi. Kukumbukira zomwe umadya komanso kuchuluka kwa zomwe ukudya kungakuthandizeni kuti muchepetse thupi ngati muchita bwino. Kuti mupeze upangiri wabwino wazomwe mungadye kuti muchepetse thupi muyenera kukambirana ndi adotolo, koma kusintha pang'ono ngati kudya zipatso ndi ndiwo zamasamba kungakhale njira yabwino yoyambira.

Zakudya zopangidwa, zopatsa mphamvu, shuga, ndi mowa ndi zitsanzo za zakudya zomwe zingayambitse kunenepa. Zipatso zatsopano, ndiwo zamasamba, ndi mapuloteni apamwamba kwambiri monga nsomba, nyemba, ndi mazira ndi zitsanzo zabwino za zakudya zomwe thupi limatha kusinthana mosavuta ndikupeza michere yofunikira.

2. Muzichita masewera olimbitsa thupi nthawi zonse

Malinga ndi Centers for Disease Control and Prevention ( CDC ), kuchita masewera olimbitsa thupi kumangothandiza kuchepetsa kunenepa, koma kumachepetsa kuthamanga kwa magazi, kumachepetsa chiopsezo cha mtundu wachiwiri wa matenda ashuga, komanso kumatha kuchepetsa zizindikilo za kupsinjika ndi nkhawa. Anthu amasiyana mosiyanasiyana kuchuluka kwa zolimbitsa thupi zomwe amafunikira kuti achepetse kunenepa, motero ndibwino kuti mukambirane ndi adotolo za momwe muyenera kuchitira masewera olimbitsa thupi kangati. Zina mwazochita zolimbitsa thupi zimaphatikizapo kuyenda, kupalasa njinga, kusambira, ndi masewera olimbitsa thupi.

3. Kuchepetsa nkhawa

Kupsinjika kumalumikizidwa ndi mavuto ambiri azaumoyo monga nkhawa komanso kukhumudwa. Kumva kupsinjika kumatha kubweretsa kudya kwamaganizidwe, komwe kumatha kubweretsa kunenepa pakapita nthawi. Kupeza njira zochepetsera nkhawa kungakuthandizeni kuti muchepetse kunenepa. Mutha kuyesa kusinkhasinkha, yoga, kuyenda, kapena kuyimbira mnzanu kapena wachibale. Muthanso kufunsa dokotala kapena mlangizi za njira zotsimikizika zochepetsera kupsinjika komwe kungakwaniritse moyo wanu.

4. Muzigona mokwanira

Malinga ndi Tulo Togona , Kusowa tulo kumawonjezera chilakolako ndikubweretsa zovuta zamagetsi. Kugona mokwanira kumatha kuthandizira kuti thupi lanu lizigwira ntchito bwino ndikupatseni mphamvu zambiri zochitira zinthu monga masewera olimbitsa thupi, zomwe zingakuthandizeni kuti muchepetse thupi. Kugona mokwanira kumathandizanso kuti muchepetse nkhawa, zomwe zingakuthandizeni kuthana ndi zomwe mungakonde kudya kwambiri.

5. Kuyesa mapiritsi azakudya zabwino ndi zowonjezera

Pali mapiritsi azakudya zambiri komanso zowonjezera pamsika zomwe zimati zimayambitsa kuchepa thupi, monga Hydroxycut ndi glucomannan, koma siziyenera kukhala m'malo mwa kusintha kwa moyo wathanzi. Anthu akamapita kukamwa mankhwala ochepetsa kunenepa, ambiri a iwo amachita izi chifukwa ndizosavuta, Dr. Singh akutero. Ngati wina asintha kaye moyo wake ndi kadyedwe koyamba, awona kusintha kolimba ndi Topamax kapena mankhwala ena ochepetsa thupi. Malingaliro ndi chinthu chofunikira kwambiri. Mankhwala sangakhale m'malo mwa kudya koyenera komanso zizolowezi zolimbitsa thupi.