Kodi beta blocker yabwino kwambiri yolephera mtima ndi iti?

Zambiri Zamankhwala

Beta blockers ndi mankhwala omwe amayesedwa bwino komanso osunthika. Osamalira zaumoyo akhala akuwapatsa iwo kuyambira m'ma 1970 . Oletsa Beta muli ndi chilolezo cha FDA chochiza chilichonse kuyambira glaucoma mpaka migraines. Koma, amagwiritsidwanso ntchito pochiza matenda amtima-nthawi zambiri ngati chithandizo choyamba cha kulephera kwa mtima.

Kodi beta blockers amagwira ntchito bwanji?

Beta blockers amagwira ntchito poletsa zotsatira za epinephrine (yemwenso amadziwika kuti adrenaline) -hormone yamavuto. Izi zimachepetsa kugunda kwanu, zimachepetsa kuthamanga kwa magazi, komanso zimatsegula mitsempha yamagazi kuti magazi aziyenda bwino. Mankhwalawa amatha kuthana ndi kuthamanga kwa magazi (matenda oopsa), mtima wosakhazikika (arrhythmia), kupweteka pachifuwa, mtima kulephera, mutu waching'alang'ala, ndi matenda amtima.

Kwa odwala omwe ali ndi vuto la mtima, ma beta blockers nthawi zambiri amagwira ntchito [kuti achepetse nkhawa pamtima] pochepetsa kugunda kwa mtima wa wodwala, akufotokoza Dawn Shill , Pharm.D., Wamankhwala ku Veteran's Affairs Healthcare System ku Anchorage, Alaska.

Oletsa ma Beta amathandizira kukonza magwiridwe antchito am'maso ndi zofunikira. Dr. Shill akuti, Kwenikweni, nthawi zina kulephera kwa mtima ndimischemic. Kutanthauza, pali minofu yofooka mumtima yomwe imayambitsa kutsika kwa magazi opopa kuchokera mumtima. Beta blockers amatha kuthandizira kukonza magwiridwe antchito am'madera ena amtima pochepetsa kuchuluka kwa mpweya wofunikira kuti mtima ugwire bwino ntchito.

Kafukufuku akuwonetsanso kuti ma beta blockers amachepetsa kutulutsa kwa norepinephrine. Pamodzi ndi epinephrine, norepinephrine nthawi zambiri imamangiriza kuzilandira mthupi lonse ndipo imakhudzidwa ndi kuthamanga kwa magazi komanso kugunda kwa mtima. Kuletsa kumangiriza kwa ma neurotransmitters awa kuma receptors awo kumathandiza kuchepetsa kugunda kwa mtima ndi kuthamanga kwa magazi.

Ndi ma block blocker ati omwe angagwiritsidwe ntchito polephera mtima?

Beta blockers nthawi zambiri amapatsidwa kwa odwala omwe ali ndi vuto la mtima cholinga ndikuti ateteze kugwidwa kwamtima kwachiwiri kuti kusachitike.

Pulogalamu ya American College of Cardiology akuvomereza makamaka zotsatirazi za beta, zomwe FDA imavomereza kulephera kwa mtima:

• Coreg (chosema)
• Toprol XL (metoprolol succinate)
• Zebeta (bisoprolol)

Ndikofunikira kudziwa kuti mtundu wokhawo wa metoprolol (metoprolol succinate) imavomerezedwa ndi FDA yolephera mtima, ayi metoprolol tartrate .

Mukamagwiritsa ntchito ma blocker a beta pamankhwala ochepetsa mtima, amaletsa mtima kuti usakhale wopitilira muyeso komanso kupopera pafupipafupi, akufotokoza Jason Reed , Chipatala.

Ma beta blockers ambiri amachepetsanso momwe mapampu amitima yamtima amalimbikira, Dr. Reed akufotokoza. Koma ma beta blockers samachita izi, ndichifukwa chake amatha kuchiza matendawa osapangitsa kuti zizindikilo ziwonjezeke.

Mu mfundo za kusiyana pakati pa blockers beta amagwiritsidwa ntchito polephera mtima, akuti,carvedilol imatseka beta-1 beta-2 receptors mumtima, komanso alpha-1 receptors mumitsempha yamagazi. Metoprolol ndi bisoprolol makamaka zimatseka zolandilira za beta-1 mumtima. Ngakhale ma beta blockers awa ali ndi zosiyana, amathandiza kuteteza mtima ndikuchepetsa mavuto omwe amabwera chifukwa cha kulephera kwa mtima.

Ma beta blockers abwino kwambiri olephera mtima
Dzina (dzina lodziwika bwino)	Mlingo	Kuchita bwino (poyerekeza ndi placebo)	Zotsatira zoyipa	Dziwani zambiri	Pezani coupon
Coreg (chosema)	3.125 mg kawiri tsiku lililonse kwa milungu iwiri, ndikutsatiridwa ndi kuchuluka kwamasabata milungu iwiri iliyonse kufikira zitakwaniritsidwa. Kuchuluka kwa 25 mg kawiri tsiku lililonse kwa odwala osakwana 85 kg ndi 50 mg kawiri tsiku lililonse kwa odwala omwe amalemera makilogalamu oposa 85.	65% kuchepetsa ngozi zakufa	Chizungulire , kutopa, kupweteka mutu, kunenepa, kutsegula m'mimba	Dziwani zambiri	Pezani coupon
Toprol XL (metoprolol succinate)	12.5 mpaka 25 mg kamodzi tsiku lililonse kwamasabata awiri, kenako ndikuwonjezeka milungu iwiri iliyonse kufikira zitakwaniritsidwa. Kutalika kwa 200 mg patsiku.	3. 4% kuchepetsa ngozi zakufa	Chizungulire , kukhumudwa, kutopa, kupuma, kutsegula m'mimba	Dziwani zambiri	Pezani coupon
Zebeta (bisoprolol)	1.25 mg kamodzi tsiku lililonse kwa masiku awiri, kenako 2.5 mg kamodzi tsiku lililonse kwa mwezi woyamba, kenako 5 mg kamodzi patsiku. Kutalika kwa 10 mg patsiku.	3. 4% kuchepetsa ngozi zakufa	Mutu , chizungulire, kupweteka kwa mafupa, kutsegula m'mimba, kutopa	Dziwani zambiri	Pezani coupon

Ndi mankhwala ati omwe mwapatsidwa atha kudalira kuuma kwa mtima womwe mukukumana nawo. Dokotala wanu adzaganiziranso zamankhwala am'mbuyomu omwe mudayesapo komanso zovuta zina zomwe mudakumana nazo kale. Mwachitsanzo, bisoprolol imagwiranso ntchito ngati beta blockers yolephera mtima, koma itha kuyambitsa kutopa pang'ono kuposa ma beta blockers osasankha monga carvedilol.

Liti (ndi motani) beta blockers amalembedwa

Ma Beta blockers samalimbitsa mtima, amangoyimitsa dongosolo lamanjenje kuti lisakulitse.Izi zimalepheretsa minofu ya mtima kuti izigwira ntchito mopitirira muyeso mpaka hypertrophy chifukwa cha kupsyinjika kwambiri, komwe kumatha kubweretsa matenda amtima, Dr. Reed akufotokoza.

Ngakhale ma beta blockers amatha kuchepetsa kuwonongeka kwa mtima pochotsa kupsyinjika, Dr. Shill akufotokoza kuti ngati atatengedwa molakwika atha kufooketsa mtima. Ngati sanatengeredwe monga momwe adanenera, atha kuvulaza koposa zabwino.Ma Beta blockers amatha kuyambitsa kuchepa kwa mtima koopsa kotchedwa bradycardia komwe kumatha kubweretsa kutsika kwa magazi.Izi zitha kuyambitsa zizindikilo monga chizungulire, nseru, kukomoka, kusowa ndende, kapena kusawona bwino.

Malingana ngati wodwala ali wolimba komanso beta blocker yoyenera imaperekedwa muyezo woyenera, ma beta blockers amatha kugwiritsidwa ntchito bwino pochiza kulephera kwa mtima. Mchitidwe wamanjenje wachifundo ukuchita mopitirira muyeso ndikuyika kupsinjika pamtima ndichifukwa chake ma beta blockers ayambitsidwa ndikupitiliza, Dr. Reed akutero. Pambuyo polephera mtima kwambiri, odwala ambiri adzapitiliza chithandizo cha beta blocker. Beta blockers awonetsedwa kuti amachepetsa kufa, ndipo pali umboni wamphamvu wotsimikizira kugwiritsa ntchito kwawo.

Odwala amatha kupatsidwa beta blocker yochepa pamtima poyambira. Amatha kuwunika zovuta zilizonse motsogozedwa ndi dokotala kwa sabata limodzi kapena awiri. Malingana ngati mankhwalawa akulekerera bwino, wothandizira zaumoyo amatha kukulitsa pang'ono pang'onopang'ono mpaka zizizire, malinga ndi Dr. Reed.

Ndani ayenera ayi ntchito beta blockers?

Ngakhale ma beta blockers atha kupulumutsa moyo wa odwala ena, sizili choncho kwa aliyense.Ngati wodwala akukumana congestive mtima kulephera Pamodzi ndi zovuta zina monga COPD, matenda ashuga kapena zotumphukira mitsempha, ma beta blockers sangakhale njira yoyenera yothandizira. Oletsa Beta ayenera kupewedwa ndi odwala omwe ali ndi mphumu ndi COPD, Dr. Reed akuti. Komanso si lingaliro labwino kwa odwala omwe ali ndi kuchepa kwa mtima kapena kuthamanga kwa magazi.

Monga mankhwala onse, ma beta blockers amatha kukhala ndi zotsatirapo.

Postural hypotension ndi vuto lalikulu kwa anthu ambiri omwe ali ndi beta blockers, Dr. Reed akufotokoza. Izi zimatha kuyambitsa chizungulire kapena kukomoka.

Ma beta blockers amathanso kuyambitsa zovuta zina monga kukhumudwa, kutopa, komanso kuwonongeka kwa erectile, zomwe zingakhale zovuta zoyipa kwambiri za mankhwalawa.

Ndiye palinso kulumikizana kwa mankhwala komwe kungaganizidwe. Ena mwa mankhwala omwe amagwiritsidwa ntchito kwambiri omwe amagwirizana ndi beta blockers ndi ma NSAID ndi mankhwala oletsa zilonda, Dr. Reed akuti.

Kuphatikiza pa ma NSAID ndi mankhwala oletsa zilonda, pali mndandanda wautali wa kuyanjana kotheka kudziwa. Odwala ayenera kukambirana ndi madokotala za chitetezo cha beta blocker ngati atenga izi:

• Kuthamanga kwa magazi kutsitsa mankhwala
• Mankhwala ena amtima monga antianginal kapena antiarrhythmic
• Mankhwala a Psychotropic monga antidepressants
• Mankhwala oletsa ululu
• Mankhwala a Statin
• Warfarin
• Mankhwala a shuga
• Maantibayotiki ena monga Rifampin

Nthawi zambiri, ma beta blockers ndimachiritso othandiza olephera mtima, amachepetsa chiopsezo chakufa chifukwa cha kulephera kwa mtima, komanso amachepetsa chiopsezo chamatenda amtima. Lankhulani ndi dokotala wanu za zovuta zilizonse zomwe mungakhale nazo, ndipo onetsetsani kuti munena zoyipa zilizonse zomwe mumakumana nazo mukamagwiritsa ntchito beta blocker.