Trulance vs.Linzess: Kusiyana, kufanana, ndi zomwe zili zabwino kwa inu
Mankhwala osokoneza bongo Vs. MnzanuKuwunika kwa mankhwala osokoneza bongo & kusiyana kwakukulu | Zinthu zothandizira | Mphamvu | Kuphunzira inshuwaransi ndikufanizira mtengo | Zotsatira zoyipa | Kuyanjana kwa mankhwala | Machenjezo | FAQ
Trulance (plecanatide) ndi Linzess (linaclotide) ndi mankhwala awiri omwe angagwiritsidwe ntchito pochiza matenda am'mimba (IBS). Mankhwala onsewa amalimbikitsa kutuluka kwamatumbo powonjezera kuchuluka kwa madzimadzi m'matumbo. Pamlingo wamankhwala am'magazi, Trulance ndi Linzess amakhala ngati agonists a guanylate cyclase-C receptors m'matumbo. Izi zimathandizanso kuti madzi aziyenda pang'ono, amachepetsa kapangidwe kake, ndikufulumizitsa chakudya.
Trulance ndi Linzess awonetsedwanso pochiza matenda opatsirana a idiopathic (CIC). Uwu ndiye mtundu wa kudzimbidwa komwe kulibe chifukwa chodziwika.
Mankhwala onsewa akuthandizira kudzimbidwa amafuna kuyendera kwa dokotala komanso mankhwala. Trulance ndi Linzess nawonso amatsutsana ndi ana ochepera zaka 6. Iwo sali ovomerezeka kwa aliyense wochepera zaka 18 zakubadwa.
Kodi pali kusiyana kotani pakati pa Trulance ndi Linzess?
Ngakhale onse Trulance ndi Linzess amachita pa zotengera za guanylate cyclase-C , Ali ndi mayina osiyana achibadwa komanso zowonjezera. Trulance ndi dzina la plecanatide pomwe Linzess ndiye dzina la linaclotide.
Trulance ndi mankhwala atsopano kuposa Linzess ndipo amatha kumwa kapena wopanda chakudya. Linzess nthawi zambiri amatengedwa m'mimba yopanda kanthu mphindi 30 musanadye chakudya cham'mawa. Ngakhale Trulance imapezeka ngati piritsi yamlomo ya 3 mg, Linzess imapezeka ngati kapisozi wamlomo mwamphamvu zosiyanasiyana.
| Kusiyana kwakukulu pakati pa Trulance ndi Linzess | ||
|---|---|---|
| Kuthamanga | Linzess | |
| Gulu la Mankhwala | Guanylate cyclase-C agonist | Guanylate cyclase-C agonist |
| Chizindikiro cha Brand / generic | Palibe mtundu wa generic womwe ulipo | Palibe mtundu wa generic womwe ulipo |
| Dzina Lopangika | Plecanatide | Zamatsenga |
| Kupezeka kwa Fomu Yachibadwa | Sakupezeka | Sakupezeka |
| Kodi mankhwalawa amabwera mwa mawonekedwe ati? | 3 mg piritsi yamlomo | 72, 145, 290 mcg makapisozi amlomo |
| Kodi mulingo woyenera ndi uti? | Kudya kapena wopanda chakudya, kamodzi patsiku. | Muyenera kumwa mopanda kanthu kamodzi pa tsiku. |
| Kodi mankhwalawa amatenga nthawi yayitali bwanji? | Kutalika kwakanthawi malinga ndi zomwe dokotala wakuuzani | Kutalika kwakanthawi malinga ndi zomwe dokotala wakuuzani |
| Ndani amagwiritsa ntchito mankhwalawa? | Akuluakulu azaka 18 kapena kupitilira apo | Akuluakulu azaka 18 kapena kupitilira apo |
Mukufuna mtengo wabwino kwambiri pa Trulance?
Lowani zidziwitso zamitengo ya Trulance ndikupeza kuti mitengo ikasintha liti!
Pezani zidziwitso zamitengo
Zomwe amathandizidwa ndi Trulance ndi Linzess
Linzess ndi Trulance avomerezedwa kuti agwiritsidwe ntchito mu kudzimbidwa kosalekeza ndi mtundu wodziwika wa kudzimbidwa wamatenda osakwiya (IBS-C). Kupyolera muzochita zawo pazomwe zimalandira m'matumbo, mankhwala onsewa amalimbikitsa kutulutsa madzi ndi kuwonjezera chakudya kudzera m'matumbo.
Izi mankhwala-mankhwala sizomwe zimatsitsimula. Samapereka mpumulo pompopompo kuchokera kudzimbidwa. Zotsatira zimawonedwa patatha sabata limodzi akuchiritsidwa ndi Trulance ndi Linzess. Nthawi zambiri amakhala otetezeka kuti agwiritsidwe ntchito kwanthawi yayitali.
Trulance ndi Linzess nthawi zina amatha kugwiritsidwa ntchito ngati mankhwala pochotsa kupsinjika kwa opioid (OIC) komwe kumachitika chifukwa cha mankhwala ngati morphine. Zizindikiro zina zopanda chizindikiro zimaphatikizapo ulcerative colitis.
| Mkhalidwe | Kuthamanga | Linzess |
| Matenda owopsa am'mimba ndikudzimbidwa | Inde | Inde |
| Kudzimbidwa kosakhalitsa | Inde | Inde |
| Kudzimbidwa komwe kumayambitsa opioid | Kutumiza | Kutumiza |
| Zilonda zam'mimba | Kutumiza | Kutumiza |
Kodi Trulance kapena Linzess ndiyothandiza kwambiri?
Trulance ndi mankhwala atsopano poyerekeza ndi Linzess. Komabe, mphamvu ya mankhwala onsewa ndiyofanana.
Kupititsa patsogolo pafupipafupi m'matumbo kumawoneka sabata la 1 lokhala ndi zotsatira zazitali. Pamodzi ndi kuchuluka kwakanthawi kwamatumbo, mankhwalawa amathandizanso chopondapo kuphatikiza kapangidwe kake ndi kusasinthasintha.
Kuchita bwino kwa Trulance m'modzi mayesero azachipatala anapezeka kuti amadziwika kwambiri pochiza matenda akudzimbidwa kosachiritsika. Poyerekeza ndi placebo, Trulance adawonetsedwanso kuti ndi othandiza pochiza matenda am'mimba.
Pakadali pano, pali maphunziro owerengeka ochepa pakati pa Linzess ndi Trulance potengera momwe amagwirira ntchito koma zonsezi ndizothandiza kwambiri kuposa mankhwala a placebo kuti athetse kudzimbidwa. Chimodzi kuwunika mwatsatanetsatane adapeza kuti Trulance ndi Linzess ali ndi mphamvu zofananira komanso chitetezo. Panalibe kusiyana kwakukulu pakupezeka kwa zovuta monga kutsegula m'mimba.
Chisankho cha mankhwala omwe angawasankhe chitha kutsimikizidwa ndi dokotala. Pambuyo pofufuza kwathunthu, adokotala adzakupatsani mankhwala abwino kwambiri ogwirizana ndi momwe munthu alili.
Mukufuna mtengo wabwino pa Linzess?
Lowani zidziwitso zamitengo ya Linzess kuti mudziwe kuti mitengo isintha liti!
Pezani zidziwitso zamitengo
Kuphunzira ndi kuyerekezera mtengo wa Trulance vs. Linzess
Trulance idavomerezedwa mu 2017 ngati mankhwala odziwika okha. Pakadali pano amapangidwa ndi Synergy Pharmaceuticals. Pakadali pano palibe mtundu wa generic womwe ulipo. Medicare ndi mapulani ambiri a inshuwaransi sangaphimbe Trulance. Mtengo wapakatikati wa Trulance utha kukhala wopitilira $ 500. Kugwiritsa ntchito khadi yotsitsa ya SingleCare kungathandize kubweretsa mtengo wotsika $ 400. Ngakhale akadali mankhwala okwera mtengo, kugwiritsa ntchito khadi yotsitsa kumatha kubweretsa mtengo pansi pomwe inshuwaransi sichingathe kubisa.
Linzess idavomerezedwa mu 2012 ndipo imangopezeka ngati mankhwala odziwika ndi dzina. Monga ma agonists ena a guanylate cyclase-C, Linzess itha kukhala yotsika mtengo kwambiri pamtengo wotsika kuposa $ 500. Mwamwayi, ma Medicare ena ndi mapulani a inshuwaransi atha kubisa. Ngakhale mutakhala ndi inshuwaransi, mutha kusunga ndalama zambiri ndi khadi limodzi la SingleCare lomwe lingachepetse mtengo wake pafupifupi $ 400.
| Kuthamanga | Linzess | |
| Nthawi zambiri amakhala ndi inshuwaransi? | Ayi | Ayi |
| Nthawi zambiri amadzazidwa ndi Medicare? | Ayi | Ayi |
| Mlingo woyenera | Mapiritsi a 3 mg | 72, 145, 290 mcg makapisozi |
| Wopanga Medicare wamba | $ 70- $ 474 | $ 19- $ 482 |
| Mtengo wosakwatiwa | $ 389. + | $ 403.38 |
Zotsatira zoyipa za Trulance vs. Linzess
Zotsatira zoyipa zomwe zimakhudzana ndi kugwiritsa ntchito Trulance kapena Linzess ndi kutsegula m'mimba. Chifukwa cha momwe ntchito yawo imagwirira ntchito, mankhwalawa amayambitsa mavuto am'mimba. Malinga ndi zolemba zawo za FDA, Trulance itha kukhala ndi zovuta zochepa poyerekeza ndi Linzess. Chotsatira chachikulu cha Trulance ndi kutsekula m'mimba.
Kupatula kutsekula m'mimba, Linzess imatha kuyambitsa zovuta zina zodziwika bwino monga kuphulika, kuphulika, komanso kupweteka m'mimba.
Nthawi zambiri, Trulance ndi Linzess zimatha kuyambitsa kutsegula m'mimba kwambiri. Pakadali pano, adotolo amalimbikitsa kuti mankhwalawa asiye nthawi yomweyo. Kwa ana, mankhwalawa amatha kuyambitsa kuchepa kwa madzi. Chifukwa chake, salimbikitsidwa mwa ana.
| Kuthamanga | Linzess | |||
| Zotsatira zoyipa | Zoyenera? | Pafupipafupi | Zoyenera? | Pafupipafupi |
| Kutsekula m'mimba | Inde | 5% | Inde | makumi awiri% |
| Kupweteka m'mimba | Inde | <2% | Inde | 7% |
| Kuphulika | Inde | <2% | Inde | awiri% |
| Kudzikweza | Inde | <2% | Inde | 4% |
| Mutu | Ayi | - | Inde | 4% |
Izi sizingakhale mndandanda wathunthu wazovuta zomwe zingachitike. Chonde onani dokotala wanu kapena wothandizira zaumoyo kuti mudziwe zambiri.
Gwero Tsiku ndi Tsiku ( Kuthamanga ), Tsiku Lililonse ( Linzess )
Kuyanjana kwa mankhwala osokoneza bongo a Trulance vs. Linzess
Pali zochitika zingapo zamankhwala ndi Trulance. Kawirikawiri zimawoneka ngati zotetezeka kumwa mankhwala ena. Komabe, mankhwala amodzi, makamaka, amatha kuthana ndi Trulance. Idelalisib imasonyezedwa pochiza khansa zina zamagazi monga khansa ya m'magazi.
Idelalisib, ikamwedwa ndi Trulance, imatha kuyambitsa matenda otsekula m'mimba owopsa. Ndikofunika kulumikizana ndi omwe akukuthandizani nthawi yomweyo mukakumana ndi zodabwitsazi.
Kupatula idelalisib, palibenso kuyanjana kwina kwakukulu ndi mankhwala osokoneza bongo ndi Trulance. Sizimasokoneza ma enzyme a cytochrome P450 komanso sizimakhudza ma cell ena onyamula.
Linzess, mbali inayi, ali ndi mndandanda wautali wazomwe angayanjane ndi mankhwala poyerekeza ndi Trulance. Mankhwalawa amatha kuyanjana ndi mankhwala angapo monga levothyroxine, bisacodyl, psyllium, magnesium hydroxide, ndi omeprazole.
| Mankhwala osokoneza bongo | Gulu la Mankhwala | Kuthamanga | Linzess |
| Lingaliro | Phosphoinositide 3-kinase inhibitor | Inde | Osati lipoti |
| MulembeFM | Mahomoni a chithokomiro | Osati lipoti | Inde |
| Bisacodyl | Olimbikitsa mankhwala ofewetsa tuvi tolimba | Osati lipoti | Inde |
| Zamgululi | CHIKWANGWANI mankhwala ofewetsa tuvi tolimba | Osati lipoti | Inde |
| Mankhwala enaake a hydroxide | Saline mankhwala ofewetsa tuvi tolimba | Osati lipoti | Inde |
| Omeprazole | Proton pump inhibitor | Osati lipoti | Inde |
Ili si mndandanda wathunthu wazomwe zimachitika ndi mankhwala. Chonde funsani dokotala musanamwe mankhwalawa.
Machenjezo a Trulance vs. Linzess
Onse awiri Trulance ndi Linzess amatha kuyambitsa zovuta zoyipa, makamaka kutsegula m'mimba ndi kutaya madzi m'thupi.
Kwa ana ochepera zaka 6, mankhwalawa ali ndi chiopsezo chotaya madzi m'thupi. Chitetezo chawo ndi magwiridwe antchito sizinakhazikitsidwe bwino mwa ana ochepera zaka 18, ndichifukwa chake onse Trulance ndi Linzess amatsutsana ndi odwala. Kutaya madzi m'thupi kumatha kuchitika chifukwa cha kukondoweza kwa guanylate cyclase-C zolandilira zomwe zimalimbikitsa matumbo kuyenda komanso kutulutsa kwamadzi pamlingo woposa wabwinobwino.
Omwe ali ndi kutsekeka kwa m'mimba (kutsekeka) ayenera kupewa kumwa Trulance kapena Linzess. Lankhulani ndi dokotala kuti mudziwe ngati muli ndi zotsekeka m'mimba musanamwe mankhwala.
Kutsekula m'mimba ndi vuto lina lofala komanso chiopsezo chomwe chitha kuchitika pogwiritsa ntchito Trulance ndi Linzess. Kutsekula m'mimba kumangoyambitsa kuchepa kwa madzi m'thupi komanso kusokonekera kwa ma electrolyte mthupi. Izi zitha kufuna chithandizo china ngati sichikukonzedwa moyenera.
Trulance ndi Linzess sizinaphunzirepo mwa amayi omwe ali ndi pakati kapena akuyamwitsa. Ayenera kugwiritsidwa ntchito pokhapokha atawunikiranso zomwe zitha kukhala zovuta zakubadwa.
Mafunso omwe amafunsidwa pafupipafupi za Trulance vs. Linzess
Kodi Trulance ndi chiyani?
Trulance ndi mankhwala akuchipatala omwe amavomerezedwa pochiza matenda akudzimbidwa (IBS-C) komanso kudzimbidwa kosachiritsika kwa idiopathic (CIC). Ndi guanylate cyclase-C receptor agonist yomwe imakulitsa matumbo kuyenda. Trulance ndiyabwino kugwiritsidwa ntchito kwa odwala azaka zopitilira 18. Icho chimabwera mu mawonekedwe apiritsi apakamwa ndi kupumula komwe kumawoneka patangotha sabata imodzi yogwiritsidwa ntchito.
Linzess ndi chiyani?
Linzess ndi mankhwala akale omwe amachita mofananamo ndi Trulance. Ndi guanylate cyclase-C receptor agonist yomwe imakulitsa mayendedwe m'matumbo ndikuchepetsa kudzimbidwa. Pachifukwa ichi, Linzess wavomerezedwa chifukwa cha matenda opweteka a m'mimba-C komanso kudzimbidwa kosalekeza. Ndi mankhwala omwe mumamwa ndi kapisozi wamlomo.
Kodi Trulance ndi Linzess ndizofanana?
Ayi. Ngakhale ali m'gulu lomwelo la mankhwala, mankhwalawa amabwera m'njira zosiyanasiyana. Trulance ndi mankhwala atsopano omwe angamwe kapena wopanda chakudya. Linzess ayenera kumwedwa m'mimba yopanda kanthu mphindi 30 musanadye chakudya cham'mawa.
Zomwe zili bwino – Trulance kapena Linzess?
Trulance ndi Linzess ali ndi mphamvu zofananira komanso chitetezo. Komabe, Linzess itha kukhala yolumikizidwa ndi chiwopsezo chachikulu cha kutsegula m'mimba, kuphulika, ndi mpweya. Pachifukwa ichi, Trulance itha kusankhidwa kuposa Linzess.
Kodi ndingagwiritse ntchito Trulance kapena Linzess ndili ndi pakati?
Sizikudziwika ngati Trulance kapena Linzess ali otetezeka kutenga nthawi yapakati kapena yoyamwitsa. Muyenera kufunsa adotolo musanamwe mankhwalawa mukakhala ndi pakati kapena poyamwitsa.
Kodi ndingagwiritse ntchito Trulance kapena Linzess ndi mowa?
Kuyanjana kwa mankhwala osokoneza bongo a Trulance kapena Linzess ndi mowa sikunakhazikitsidwe bwino. Pali kuthekera kwakuti kumwa mowa ndi mankhwalawa kumatha kuwonjezera ngozi zakukumana ndi zovuta.
Kodi Amitiza aposa Linzess?
Poyerekeza ndi Linzess kamodzi-tsiku, Amitiza (lubiprostone) imafunika kumwedwa kawiri tsiku lililonse. Amitiza amathanso kukhala ndi zovuta zoyipa zambiri poyerekeza ndi Linzess. Kuphatikiza pa kutsekula m'mimba, Amitiza imatha kuyambitsa nseru, kudzimbidwa, ndi pakamwa pouma.
Kodi mtundu wa Linzess ndi uti?
Pakadali pano palibe mtundu wa Linzess womwe ukupezeka pamsika.
Zomwe zili bwino ndi kudzimbidwa-Linzess kapena Trulance?
Onse awiri Trulance ndi Linzess awonetsedwa kuti ndi ofanana mofananira ndi chitetezo. Mankhwala amodzi amatha kusankhidwa kuposa ena kutengera mtengo ndi inshuwaransi. Trulance ndi mankhwala atsopano omwe ali ndi zovuta zochepa zomwe zimafotokozedwa.
Kodi Linzess akupangitsani kuti muchepetse thupi?
Kusintha kwakuthupi ndikotheka mukamatenga Linzess. Linzess akuti amachititsa kuti achepetse thupi kapena kunenepa.
