Waukulu >> Mankhwala Osokoneza Bongo Vs. Mnzanu >> Amitiza vs.Linzess: Kusiyana, kufanana, ndi zomwe zili zabwino kwa inu

Amitiza vs.Linzess: Kusiyana, kufanana, ndi zomwe zili zabwino kwa inu

Amitiza vs.Linzess: Kusiyana, kufanana, ndi zomwe zili zabwino kwa inuMankhwala osokoneza bongo Vs. Mnzanu

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Amitiza ndi Linzess ndi mankhwala awiri omwe amagwiritsidwa ntchito pochizira matenda opatsirana a idiopathic (CIC) ndi matenda opweteka a m'mimba ndi kudzimbidwa (IBS-C). Kudzimbidwa kosadziwika bwino kumadziwika ndi miyezi isanu ndi umodzi kapena kupitilira apo ndikutuluka kwamatumbo kamodzi sabata. Matenda okhumudwitsa ndi gulu lazizindikiro zosiyanasiyana zomwe zimachitika limodzi kuphatikiza kupweteka m'mimba ndikusintha kwa matumbo: kutsegula m'mimba, kudzimbidwa, kapena zonse ziwiri. Amitiza ndi Linzess amagwiritsidwa ntchito makamaka mu IBS ndikudzimbidwa. Tikambirana kufanana ndi kusiyana pakati pa Amitiza ndi Linzess pano.



Kodi pali kusiyana kotani pakati pa Amitiza ndi Linzess?

Amitiza (lubiprostone) ndi mankhwala omwe amathandizidwa kudzimbidwa powonjezera kutulutsa kwamadzi m'matumbo. Ndi bicyclic fatty acid ndi prostaglandin E1 (PGE 1) yomwe imayambitsa ma chloride mumatumbo. Kuwonjezeka kwazomwe zimasungunuka kumasinthasintha chopondapo ndikulimbikitsa kuyenda kwamatumbo pafupipafupi. Amitiza imapezeka ngati kapisozi wofewa wamlomo mumphamvu za 8 mcg ndi 24 mcg.



Linzess (linaclotide) ndi mankhwala akuchipatala omwe amathandizidwanso kuchiritsa kudzimbidwa. Ndi guanylate cyclase C (GC-C) agonist yomwe imayambitsa kuchuluka kwa cyclic guanosine monophosphate (cGMP). Kuchita pa cholandirira cha GC-C kumapangitsa kuwonjezeka kwamatumbo. Izi zimapangitsa kuwonjezeka kwamadzimadzi am'matumbo ndikuwonjezera kutuluka kwa m'matumbo kudzera mundawo. Kuchulukitsa kwa cGMP kumaganiziridwanso kuti kungathetseretu kuchepa kwa m'mimba m'mimba wamba mu IBS. Linzess imapezeka ngati kapisozi wamlomo mu mphamvu ya 72 mcg, 145 mcg, ndi 290 mcg.

Kusiyana kwakukulu pakati pa Amitiza ndi Linzess
Amitiza Linzess
Gulu la mankhwala osokoneza bongo Bicyclic fatty acid / PGE 1 chochokera / kloride chothandizira Agonists a Guanylate cyclase C
Chizindikiro cha Brand / generic Zolemba zokha Zolemba zokha
Kodi dzina lachibadwa ndi liti? Lubiprostone Zamatsenga
Kodi mankhwalawa amabwera mwa mawonekedwe ati? Pakamwa softgel kapisozi Makapisozi apakamwa
Kodi mulingo woyenera ndi uti? 24 mcg kawiri tsiku lililonse 145 mcg kamodzi tsiku lililonse
Kodi mankhwalawa amatenga nthawi yayitali bwanji? Zosatha, zazitali Zosatha, zazitali
Ndani amagwiritsa ntchito mankhwalawa? Akuluakulu Akuluakulu

Zomwe amitiza Amitiza ndi Linzess

Amitiza ndi Linzess amawonetsedwa aliyense pakuthandizira kudzimbidwa kosachiritsika komanso matenda am'mimba opunduka. Amitiza imavomerezedwanso ndi Food and Drug Administration (FDA) pochiza kudzimbidwa komwe kumachitika chifukwa chogwiritsa ntchito opioid kupweteka pochepetsa matenda osapweteka a khansa. Izi nthawi zina zimatchedwa OIC, kudzimbidwa komwe kumayambitsa opioid.



Amitiza ndi Linzess amangotchulidwa kuti agwiritsidwe ntchito kwa akulu, ndipo kugwiritsa ntchito ana ndi achinyamata sikuvomerezedwa. Ndi dokotala wanu yekhayo amene angasankhe ngati mankhwalawa ndi abwino kwa inu.

Mkhalidwe Amitiza Linzess
Kudzimbidwa kosakhalitsa Inde Inde
Matenda owopsa am'mimba ndikudzimbidwa Inde Inde
Kudzimbidwa ndi opiate agonist (kupweteka kosatha kwa khansa) Inde Ayi

Kodi Amitiza kapena Linzess ndiwothandiza kwambiri?

KU kuwunika mwatsatanetsatane Za 21 mayesero azachipatala omwe amayang'aniridwa mosasinthika amayerekezera zomwe Amitiza, Linzess, ndi mankhwala ena odziwika akudzimbidwa. Mankhwala ena ophatikizidwa mu phunziroli anali prucalopride, tegaserod, bisacodyl, ndi polyethylene glycol (PEG). Kufufuza uku kunatsimikizira kuti zonse zomwe zimaphatikizira mankhwala zimawonetsanso mphamvu yofananira ndi placebo poyesa kumapeto kwa kukhala ndi matumbo atatu kapena kupitilira apo pamlungu. Bisacodyl, mankhwala ogwiritsira ntchito mankhwala otsegulitsa m'mimba, anali opambana kuposa Amitiza ndi Linzess potengera kusintha kwamatumbo pamlungu. Mankhwala opatsirana olimbikitsa amatha kuyambitsa kusamvana kwa ma elektrolyte ndipo amatha kukulira kulolerana kwakanthawi.

Wolembetsa angafunikire kulingalira zinthu monga zovuta, kugwiritsa ntchito mankhwala osokoneza bongo, komanso kutsatira kamodzi tsiku lililonse kapena kawiri patsiku posankha mankhwala omwe angakhale abwino kwa wodwala.



Kuyerekeza ndi kuyerekezera mtengo wa Amitiza vs. Linzess

Amitiza nthawi zambiri amapangidwa ndi mapulani azamalonda komanso a Medicare Part D, ngakhale nthawi zina amafunikiranso kuvomerezedwa kale. Mtengo wamthumba wa Amitiza ukhoza kukhala wokwana $ 282, koma coupon yochokera ku SingleCare ikhoza kutsitsa mtengo mpaka $ 176 pamasiku 30.

Linzess nthawi zambiri amapangidwa ndi mapulani azamalonda komanso a Medicare Part D, ngakhale nthawi zina amafunikiranso kuvomerezedwa kale. Popanda kufalitsa kwamtundu uliwonse, Linzess atha kukhala pafupifupi $ 640. Kuponi kwa Linzess kuchokera ku SingleCare kukuthandizani kusunga pa Linzess, ndipo mutha kulipira $ 395.

Amitiza Linzess
Nthawi zambiri amakhala ndi inshuwaransi? Inde, nthawi zina chilolezo chisanafunike Inde, nthawi zina chilolezo chisanafunike
Nthawi zambiri amakhala ndi Medicare Part D? Inde, nthawi zina chilolezo chisanafunike Inde, nthawi zina chilolezo chisanafunike
Kuchuluka 30, 24 mcg makapisozi 30, 145 mcg makapisozi
Wopanga Medicare wamba Zimasintha kutengera dongosolo Zimasintha kutengera dongosolo
Mtengo wosakwatiwa $ 176- $ 204 $ 395 mpaka $ 470

Pezani khadi yochotsera mankhwala



Zotsatira zoyipa za Amitiza vs.Linzess

Amitiza ndi Linzess ali ndi zovuta zomwe zimachitika pakati pawo, komanso zina zapadera pamankhwala aliwonse. Kutsekula m'mimba ndi chifukwa chodziwika bwino chothandizira kusiya kugwiritsa ntchito mankhwala onsewa, ndipo ndizotsatira zoyipa za mankhwala onsewa.

Amitiza Amatha kuyambitsa mseru, amapezeka pafupifupi m'modzi mwa odwala atatu alionse omwe amamwa mankhwalawa. Izi zimawoneka kuti zimachitika nthawi zambiri ngati zingatengeke m'mimba yopanda kanthu. Nthawi zina nseru iyi imakhala yayikulu komanso yofooketsa, yopangitsa odwala kuchita zinthu zatsiku ndi tsiku. Odwala ku Amitiza adanenanso zovuta monga chizungulire, kutopa, komanso kupweteka pachifuwa, pomwe odwala ku Linzess sananene izi.



Izi sizitanthauza kuti pakhale mndandanda wazovuta zonse, chonde pitani ku dokotala wanu kapena wamankhwala kuti mupeze mndandanda wathunthu.

Amitiza Linzess
Zotsatira zoyipa Zoyenera? Pafupipafupi Zoyenera? Pafupipafupi
Nseru Inde 29% Inde <2%
Kutsekula m'mimba Inde 12% Inde 16-20%
Mutu Inde khumi ndi chimodzi% Inde 4%
Kupweteka m'mimba Inde 8% Inde 7%
Kutsegula m'mimba / kuphulika Inde 6% Inde 2-3%
Kudzikweza Inde 6% Inde 4-6%
Kusanza Inde 3% Inde <2%
Edema Inde 3% Ayi n / A
Kusapeza bwino m'mimba Inde 3% Ayi n / A
Chizungulire Inde 3% Ayi n / A
Kupweteka pachifuwa Inde awiri% Ayi n / A
Dyspnea Inde awiri% Ayi n / A
Dyspepsia Inde awiri% Inde <2%
Kutopa Inde awiri% Ayi n / A
Pakamwa pouma Inde 1% Ayi n / A

Gwero: Amitiza ( Tsiku ndi Tsiku Linzess ( Tsiku ndi Tsiku )



Kuyanjana kwa mankhwala a Amitiza vs. Linzess

Amitiza ndi Linzess ayenera kugwiritsidwa ntchito mosamala kwa odwala omwe ali ndi mankhwala a anticholinergic. Mankhwala a Anticholinergic atha kulimbikitsa kudzimbidwa komanso kutsutsana ndi zomwe Amitiza ndi Linzess amapanga.

Odwala omwe ali ndi ma diuretics, monga furosemide (Lasix), ayenera kupewa Amitiza chifukwa atha kukhala pachiwopsezo chotaya potaziyamu wambiri (hypokalemia). Mwa odwalawa, Linzess atha kukhala chisankho chomwe angasankhe.



Ili si mndandanda wathunthu wazomwe zingachitike mukamagwiritsa ntchito mankhwala. Kuti muwone mndandanda wathunthu, chonde pitani kuchipatala kuchokera kwa akatswiri azachipatala a gastroenterology.

Mankhwala osokoneza bongo Gulu la mankhwala osokoneza bongo Amitiza Linzess
Atropine
Belladonna
Zamgululi
Chlordiazepoxide
Dicyclomine
Flavoxate
Glycopyrrolate
Homatropine
Hyoscyamine
Methscopolamine
Oxybutynin
Kutulutsa
Wotsutsa Inde Inde
Bismuth salicylate
Loperamide
Matenda opatsirana Ayi Inde
Bumetanide
Furosemide
Torsemide
Odzetsa okhathamira Inde Ayi
Lactulose Mankhwala otsegulitsa m'mimba Inde Ayi
Solifenacin Antimuscarinic Inde Ayi
Methadone Opioid Inde Ayi

Machenjezo a Amitiza ndi Linzess

Amitiza atha kuyambitsa nseru kwambiri. Kukula kwa mseru kumatha kuchepa potengera Amitiza ndi chakudya.

Amitiza ndi Linzess sayenera kuperekedwa kwa odwala omwe akutsekula m'mimba kwambiri chifukwa izi zitha kuyambitsa kutsekula m'mimba. Ngati kutsekula m'mimba kukuyamba mukayamba kumwa mankhwala, siyani chithandizo, ndipo kambiranani ndi omwe amakuthandizani.

Syncope, kapena chizungulire poyimirira, komanso hypotension, kapena kuthamanga kwa magazi, kumatha kuchitika Amitiza atangoyamba kumene. Odwala amayenera kuyang'anira kuthamanga kwa magazi kwawo ndikunyamuka pang'onopang'ono kuchokera pamalo omwe amakhala kuti asagwere. Adziwitseni adotolo za zamankhwala zilizonse kapena mankhwala ena omwe mungamwe omwe angawonjezere syncope.

Dyspnea, kapena kumverera kwa chifuwa komanso kupuma pang'ono, kumatha kuchitika ndi Amitiza. Chizindikirochi nthawi zambiri chimakhala mkati mwa mphindi 30 mpaka 60 za mlingo ndipo chimatha maola angapo. Izi zikachitika, muyenera kulumikizana ndi dokotala wanu.

Linzess ali ndi chenjezo lomwe lili mumabokosi komanso chodzikanira pazogwiritsa ntchito kwa ana chifukwa chokhoza kuyambitsa kuchepa kwa madzi m'thupi. Zambiri pazachenjezozi zitha kupezeka pa fda.gov .

Mafunso omwe amafunsidwa kawirikawiri za Amitiza vs. Linzess

Amitiza ndi chiyani?

Amitiza ndi mankhwala omwe amagwiritsidwa ntchito pochizira kudzimbidwa kosachiritsika komanso pochiza matenda am'mimba ndikudzimbidwa. Amitiza amavomerezedwanso kuti azigwiritsa ntchito kudzimbidwa komwe kumayambitsa opioid chifukwa cha ululu wosatha wa khansa. Zimagwira ntchito powonjezera kutulutsa kwamatumbo kusintha kusinthasintha kwa chopondapo. Imapezeka ngati kapisozi wamlomo mu 8 mcg ndi 24 mcg mphamvu.

Linzess ndi chiyani?

Linzess ndi mankhwala omwe amalandira akuchipatala omwe amawonetsedwa pochiza matenda opatsirana a idiopathic ndi matenda opweteka m'mimba ndi kudzimbidwa. Zimakulitsa matumbo am'mimba ndikupita. Amapezeka m'makapisozi pakamwa pamphamvu za 72 mcg, 145 mcg, ndi 290 mcg.

Kodi Amitiza ndi Linzess ndi ofanana?

Pomwe Amitiza ndi Linzess aliyense amachiza kudzimbidwa, sali ofanana. Amitiza ndi bicyclic fatty acid ndi prostaglandin E1 (PGE 1), ndipo imayikidwa kawiri tsiku lililonse. Linzess ali mgulu la aganyists a guanylate cyclase C (GC-C), ndipo amamuyamwa kamodzi tsiku lililonse.

Kodi Amitiza kapena Linzess ali bwino?

Amitiza ndi Linzess awonetsanso zofananira pothetsa kudzimbidwa. Olemba akhoza kuyang'ana pazinthu monga ma dosing regimens ndi zovuta poganizira kuti ndi mankhwala ati omwe ndi abwino kwa wodwala. Amitiza ndi Linzess amakonda kupsinjika kwakanthawi chifukwa mankhwala ena achikhalidwe monga zofewetsa chopondapo (mwachitsanzo docusate), mankhwala otsekemera osmotic (mwachitsanzo Miralax), kapena mankhwala olimbikitsa (monga senna) amatha kuyambitsa kusamvana kwakukulu kwa ma elektrolyte ndikupanga kulolerana ndi kugwiritsidwa ntchito kwanthawi yayitali.

Kodi nditha kugwiritsa ntchito Amitiza kapena Linzess ndili ndi pakati?

Zowopsa zokhudzana ndi mankhwala omwe amagwiritsidwa ntchito ndi Amitiza kapena Linzess sizinatsimikizidwe chifukwa palibe mayesero azachipatala okwanira kuti atsimikizire chitetezo chawo. Kugwiritsa ntchito mankhwalawa panthawi yoyembekezera kuyenera kukhala kanthawi kokhako komwe maubwino ake amaposa kuopsa kwake.

Kodi ndingagwiritse ntchito Amitiza kapena Linzess ndi mowa?

Palibe zotsutsana zachindunji zakumwa mankhwalawa ndikumwa mowa, komabe, ndikofunikira kudziwa kuti mowa ungayambitse kuchepa kwa madzi m'thupi ndi kutsekula m'mimba, monganso mankhwalawa, zomwe zimaika odwala pachiwopsezo cha kuchepa kwa madzi m'thupi.

Kodi Amitiza amachititsa kunenepa?

Amitiza sanawonetsedwe kuti amapangitsa kunenepa.

Zimatenga nthawi yayitali bwanji kuti Linzess agwire ntchito?

Chithandizo chodzimbidwa nthawi zambiri chimachitika pakadutsa sabata limodzi kapena awiri, ndikuwonjezekabe kwazizindikiro zomwe zimachitika mpaka milungu 12.

Ndani sayenera kutenga Amitiza?

Odwala omwe ali ndi zotchinga m'matumbo awo (GI) sayenera kumwa Amitiza. Komanso, odwala omwe akutsekula m'mimba pang'ono sayenera kumwa Amitiza. Amayi omwe ali ndi pakati kapena akuyamwitsa, komanso odwala ana, ayenera kupewa Amitiza.