Estrace vs. Premarin: Kusiyana, kufanana, ndi zomwe zili zabwino kwa inu
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Ngati mukumva zizindikiro zakutha kwa msambo, monga kutentha, thukuta usiku , mavuto ogona, komanso kuuma kwa nyini, wothandizira zaumoyo wanu mwina atanena za mankhwala obwezeretsa mahomoni kapena mankhwala a estrogen. Zizindikiro zakutha msambo zimachitika thupi likamachepetsa estrogen, chifukwa chake mankhwala omwe amalowetsa m'malo mwa estrogen amatha kuthandiza kukonza izi, komanso amathandizira kupewa kufooka kwa mafupa.
Mwa amayi omwe ali ndi chiberekero, mankhwala a mahomoni Zimaphatikizapo estrogen ndi progesterone. Amayi omwe ali ndi chiberekero, estrogen yokha imawonjezera chiopsezo cha khansa ya endometrial.
Amayi opanda chiberekero (omwe adachitidwa ndi hysterectomy) safunika kumwa progesterone ndi estrogen. Amayi awa amatha kugwiritsa ntchito zinthu za estrogen zokha monga Estrace kapena Premarin.
Estrace ndi Premarin ndimankhwala awiri omwe amadziwika kuti amathandizira pakutha kwa kusamba. Mankhwala onsewa amavomerezedwa ndi United States Food and Drug Administration (FDA). Ali mgulu la mankhwala otchedwa estrogens ndipo amadziwikanso kuti mankhwala obwezeretsa mahomoni. Amapezeka m'njira zosiyanasiyana, kuphatikiza mafuta ndi mapiritsi. Ngakhale kuti Estrace ndi Premarin ali ndi estrogen, sizofanana ndendende. Pitirizani kuwerenga kuti mudziwe zambiri za Estrace ndi Premarin.
Kodi pali kusiyana kotani pakati pa Estrace ndi Premarin?
Estrace imapezeka mu mtundu wa generic ndipo imakhala ndi zosakaniza kutha . Estrace imapezeka ngati kirimu ya ukazi wa estrogen, komanso piritsi lamlomo.
Premarin imapezeka ngati mankhwala odziwika okha. Lili ndi ma estrogen osakanikirana, oyeretsedwa kuchokera mkodzo wapakati (chifukwa chake dzina loti Premarin- PREgnant MARes urINe). Premarin imapezeka ngati kirimu ya ukazi wa estrogen, piritsi yamlomo, kapena jakisoni.
| Kusiyana kwakukulu pakati pa Estrace ndi Premarin | ||
|---|---|---|
| Estrace | Premarin | |
| Gulu la mankhwala osokoneza bongo | Estrogens / mankhwala othandizira mahomoni | Estrogens / mankhwala othandizira mahomoni |
| Chizindikiro cha Brand / generic | Brand ndi generic | Mtundu |
| Kodi dzina lachibadwa ndi liti? | Estradiol | Mankhwala osokoneza bongo |
| Kodi mankhwalawa amabwera mwa mawonekedwe ati? | Ukazi ukazi, piritsi m'kamwa | Ukazi ukazi, piritsi m'kamwa, jekeseni |
| Kodi mulingo woyenera ndi uti? | Kirimu: 2 mpaka 4 magalamu vaginally tsiku lililonse kwa masabata 1-2, kenako pang'onopang'ono amachepetsa mpaka 1 gramu 1-3 kamodzi pa sabata Mapiritsi: amasiyana | Kirimu: 0,5 magalamu kumaliseche kawiri pa sabata Mapiritsi: amasiyana |
| Kodi mankhwalawa amatenga nthawi yayitali bwanji? | Zimasintha | Zimasintha |
| Ndani amagwiritsa ntchito mankhwalawa? | Amayi omwe atha msinkhu, nthawi zina mwa amuna kuti adziwe zina (onani m'munsimu) | Amayi omwe atha msinkhu, nthawi zina mwa amuna kuti adziwe zina (onani m'munsimu) |
Zomwe amathandizidwa ndi Estrace ndi Premarin
Kirimu cha Estrace ndi premarin kirimu zimathandizira kuziziritsa pang'ono mpaka kuzizindikiro zakumaliseche ndi kumaliseche kwa abambo (kupatulira, kuyanika, ndi kutupa) chifukwa chakutha.
Pamapiritsiwa, Estrace ndi Premarin amathandizira zinthu zina zosiyanasiyana zomwe zalembedwa patsamba ili pansipa.
| Mkhalidwe | Estrace | Premarin |
| Zizindikiro zolimbitsa thupi mpaka kumaliseche chifukwa cha kusamba | Inde (zonona) | Inde (zonona) |
| Chithandizo cha hypoestrogenism chifukwa cha hypogonadism, castration, kapena primary ovarian failure | Inde (piritsi) | Inde (piritsi) |
| Chithandizo cha khansa ya m'mawere (pakungotonthoza kokha) mwa amayi ndi abambo ena omwe ali ndi matenda am'mimba | Inde (piritsi) | Inde (piritsi) |
| Kuchiza kwa carcinoma yodalira adrogen yomwe imadalira kwambiri (pakungolira kokha) | Inde (piritsi) | Inde (piritsi) |
| Kupewa kufooka kwa mafupa kwa amayi omwe ali pachiwopsezo cha postmenopausal kwa amayi omwe ali pachiwopsezo chachikulu, pomwe mankhwala omwe si a estrogen sioyenera | Inde (piritsi) | Inde (piritsi) |
| Chithandizo cha atrophic vaginitis ndi kraurosis vulvae | Kutumiza | Inde (zonona) |
| Chithandizo cha dyspareunia yayikulu mpaka yolimba (yogonana) chifukwa chakutha | Kutumiza | Inde (zonona) |
| Chithandizo cha zizindikilo zolimbitsa thupi kwambiri chifukwa cha kusamba | Inde (piritsi) | Inde (piritsi) |
Kodi Estrace kapena Premarin ndiyothandiza kwambiri?
Kafukufuku akuwonetsa kuti poyerekeza zopangidwa ndi estrogen, estradiol (chosakaniza ku Estrace) ndi conjugated estrogens (chosakanizira cha Premarin) ndizothandizanso kuthana ndi kusamba kwa kusamba. Mafuta a ukazi ndi othandiza komanso olekerera bwino.
Wothandizira zaumoyo wanu amatha kudziwa kuti ndi mankhwala ati omwe angakhale oyenera kwa inu, poganizira zizindikiro zanu, zamankhwala, komanso mbiri yazachipatala.
Kuphatikiza ndi kuyerekezera mtengo kwa Estrace vs. Premarin
Mapulani a inshuwaransi ndi Medicare amapangira Estrace ndi Premarin.
Mankhwala wamba a Estrace ndi a chubu wa kirimu ndipo amawononga pafupifupi $ 36 ngati mutalipira m'thumba, koma kugwiritsa ntchito coupon yaulere ya SingleCare kumatha kubweretsa mtengo mpaka $ 6.
Mankhwala oyenera a chubu Premarin amawononga $ 250 mthumba. Khadi la SingleCare limatha kubweretsa mtengo wotsika mpaka $ 198.
Monga mapulani amasiyanasiyana, funsani omwe amakupatsani inshuwaransi kuti mumve zambiri.
| Estrace | Premarin | |
| Nthawi zambiri amakhala ndi inshuwaransi? | Inde | Inde |
| Nthawi zambiri amakhala ndi Medicare Part D? | Inde | Inde |
| Kuchuluka | 1 chubu | 1 chubu |
| Wopanga Medicare wamba | $ 1- $ 36 | $ 2- $ 451 |
| Mtengo wosakwatiwa | $ 6 + | $ 198 + |
Zotsatira zoyipa za Estrace vs. Premarin
Zotsatira zoyipa kwambiri za Estrace ndi Premarin kirimu zimaphatikizira momwe tsamba limagwirira ntchito ngati kuyabwa, kutulutsa, kutuluka magazi kwa uterine, ndi kutupa. Kuphatikiza apo, kupweteka kwa mutu komanso kupweteka m'chiuno kumatha kuchitika. Kuchuluka kwa zotsatirapo zake sikuphatikizidwa pakupereka chidziwitso cha Estrace.
Zotsatira zoyipa za Estrace ndi Premarin mu mawonekedwe apiritsi ndizochulukirapo. Zina mwa zotsatirazi zimaphatikizapo kupweteka m'mimba kapena msana, kufooka, kutupa, kupweteka kwa mutu, kudzimbidwa, mpweya, kunyoza, kunenepa, kukhumudwa, mantha, chizungulire, kupweteka kwa m'mawere / kupweteka / kusintha, komanso kutuluka kwamadzi, magazi, kapena yisiti.
Ili si mndandanda wathunthu wazotsatira. Zotsatira zina zoyipa zimatha kuchitika. Funsani omwe amakuthandizani kuti akambirane zovuta zomwe mungayembekezere, ndi momwe mungazithetsere.
| Kokani zonona | Premarin kirimu | |||
| Zotsatira zoyipa | Zoyenera? | Pafupipafupi | Zoyenera? | Pafupipafupi |
| Mutu | Inde | % sananene | Inde | 3-5% * |
| Kupweteka kwa m'mimba | Inde | % sananene | Inde | 4% |
| Kuyabwa | Inde | % sananene | Inde | 1-2% |
| Kutulutsa kumaliseche | Ayi | - | Inde | 3-4% |
| Kutuluka kumaliseche | Inde | % sananene | Inde | 1-2% |
| Kutupa kumaliseche | Inde | % sananene | Inde | 1-2% |
| Matenda ukazi / matenda yisiti | Inde | % sananene | Inde | 3-4% |
* zimadalira pafupipafupi
Gwero: DailyMed ( Kokani zonona ), Tsiku Lililonse ( Premarin kirimu )
Kuyanjana kwa mankhwala osokoneza bongo a Estrace vs. Premarin
Estrace kapena Premarin atha kukhudzidwa ndi mankhwala ena omwe amapangika ndi enzyme yotchedwa cytochrome-p 450 3A4. Mankhwala omwe amaletsa enzyme amachepetsa kukonzanso kwa thupi kwa Estrace kapena Premarin, kutanthauza kuti Estrace kapena Premarin atha kukhala m'thupi nthawi yayitali, ndikupangitsa zovuta zina. Komanso, mankhwala omwe amachititsa kuti enzyme ipangitse thupi kutulutsa Estrace kapena Premarin mwachangu, ndikupangitsa kuti isamagwire bwino ntchito. Funsani wothandizira zaumoyo wanu za momwe mungachitire ndi mankhwala osokoneza bongo.
| Mankhwala osokoneza bongo | Gulu la mankhwala osokoneza bongo | Estrace | Premarin |
| Clarithromycin Mankhwalawa Madzi amphesa Chinthaka Ketoconazole Ritonavir | CYP3A4 enzyme inhibitors | Zotheka | Zotheka |
| Carbamazepine Phenobarbital Rifampin Wort wa St. | CYP3A4 imathandizira ma enzyme | Zotheka | Zotheka |
Machenjezo a Estrace ndi Premarin
Estrace ndi Premarin ali ndi chenjezo la bokosi , ndilo chenjezo lamphamvu kwambiri lofunidwa ndi FDA. Chifukwa kuyamwa kwa systemic kumatha kuchitika ndi Estrace kapena Premarin kirimu, machenjezo amagwiritsidwa ntchito pamitundu yonse.
Estrogen yokha:
- Kugwiritsa ntchito estrogen yokha (popanda progestin) mwa mayi yemwe ali ndi chiberekero kumawonjezera ngozi ya khansa ya endometrial. Kuwonjezera progestin ku mankhwala a estrogen kungachepetse chiopsezo cha khansa ya endometrial (koma kungapangitse chiopsezo cha khansa ya m'mawere). Amayi a Postmenopausal omwe ali ndi magazi osazolowereka ayenera kuyesedwa kuti athetse zilonda.
- Musagwiritse ntchito estrogen yokha kupewa matenda amtima kapena matenda amisala. Akazi a Health Initiative (WHI) kuphunzira adapeza chiopsezo chowonjezeka cha sitiroko ndi DVT (deep vein thrombosis, kapena magazi m'miyendo) mwa amayi omwe atha msambo omwe amatenga estrogen okha (opanda progestin).
- Kafukufukuyu adawonetsanso chiopsezo chowonjezeka cha matenda amisala mwa azimayi omwe atha msambo omwe amatenga estrogen okha.
Estrogen kuphatikiza progestin:
- Musagwiritse ntchito estrogen kuphatikiza progestin popewa matenda amtima kapena misala. Kafukufuku wa WHI adapeza zoopsa zazikulu za DVT, PE (pulmonary embolism), stroke, ndi MI mwa azimayi omwe atha msinkhu omwe amatenga estrogen kuphatikiza progestin. Kafukufukuyu adawonetsanso chiopsezo chachikulu chokhala ndi matenda amisala mwa amayi omwe atha msinkhu omwe amatenga estrogen kuphatikiza ma progestin.
- Kafukufuku wa WHI adawonetsanso chiopsezo chowonjezeka cha khansa ya m'mawere yowopsa ndi estrogen kuphatikiza progestin.
Chifukwa chake, ma estrogens, mosasamala kanthu kuti amalembedwa kapena alibe ma progestin, ayenera kupatsidwa mlingo wotsika kwambiri komanso kwakanthawi kochepa. Lankhulani ndi omwe amakuthandizani zaumoyo za kuopsa komwe kungapindule ndi mitundu ingapo yamankhwala obwezeretsa mahomoni.
Dokotala wanu adzakupatsani upangiri wa zamankhwala pakuwunika. Amayi onse amayenera kukayezetsa chaka chilichonse ndi akatswiri azaumoyo komanso kudzipima mwezi uliwonse. Amayi onse amayeneranso kukhala ndi mammography kutengera zaka, zoopsa, komanso mbiri.
Machenjezo ena a Estrace ndi Premarin amatsatira.
Musagwiritse ntchito Estrace kapena Premarin ngati muli ndi:
- Kutuluka magazi kosadziwika bwino
- Khansa ya m'mawere (yodziwika, yokayikira, kapena mbiri)
- Neoplasia yodalira Estrogen (yodziwika kapena yokayikiridwa)
- DVT kapena pulmonary embolism (yogwira kapena mbiri)
- Yogwira kapena mbiri ya matenda a thromboembolic (stroke, MI)
- Zomwe anaphylactic anachita ku estrogen
- Matenda a chiwindi
- Matenda a thrombophilic
- Mimba (yodziwika kapena yokayikiridwa)
Kuphatikiza kwamankhwala othandizira mahomoni (estrogen kuphatikiza progestin) kumatha kuwonjezera ngozi ya khansa yamchiberekero.
Amayi omwe atenga msambo omwe amatenga estrogen ali ndi chiwopsezo cha matenda am'mimba omwe amafunika kuchitidwa opaleshoni.
Mwa anthu omwe amatenga ma estrogens, zovuta zowoneka zachitika. Funsani chithandizo chamankhwala mwachangu ngati mwataya masomphenya (pang'ono kapena kwathunthu), masomphenya awiri, diso lakuthwa, kapena mutu waching'alang'ala.
Nthawi zina, thupi lawo siligwirizana. Ngati muli ndi ming'oma, kuyabwa, kupuma movutikira, kusanza, kapena kutupa nkhope, milomo, lilime, manja, kapena mapazi, pitani kuchipatala mwadzidzidzi nthawi yomweyo. Mankhwala a Estrogen amatha kukulitsa zizindikiritso za angioedema mwa amayi omwe ali ndi cholowa cha angioedema.
Lankhulani ndi omwe amakuthandizani azaumoyo za zoopsa izi musanatenge Estrace kapena Premarin, kuti muwone ngati mankhwalawo ndi abwino kwa inu.
Mafunso omwe amafunsidwa pafupipafupi za Estrace vs. Premarin
Kodi Estrace ndi chiyani?
Estrace ndi mankhwala obwezeretsa mahomoni omwe ali ndi estradiol. Amagwiritsidwa ntchito pazizindikiro zosiyanasiyana, makamaka pazizindikiro zakusamba. Estrace imapezeka ngati kirimu wamkati komanso piritsi lamlomo.
Kodi Premarin ndi chiyani?
Premarin imakhalanso mankhwala obwezeretsa mahomoni. Premarin imakhala ndi ma estrogen osakanikirana. Amagwiritsidwa ntchito pazizindikiro zingapo, makamaka pazizindikiro zakutha. Premarin imapezeka ngati piritsi yamlomo, kirimu wamkati, ndi jakisoni.
Kodi Estrace ndi Premarin ndi ofanana?
Estrace ndi Premarin ndi ofanana, koma osafanana ndendende. Zomwe zili pamwambazi zikuwonetsa kusiyana pakati pa mankhwala awiriwa.
Kodi Estrace kapena Premarin ndiyabwino?
Mankhwala onsewa ndi othandiza kuthana ndi kusamba kwa thupi, komabe, mankhwalawa amabwera ndi zovuta komanso zoopsa. Lankhulani ndi omwe amakuthandizani kuti muwone ngati Estrace kapena Premarin ndi yoyenera kwa inu.
Kodi nditha kugwiritsa ntchito Estrace kapena Premarin ndili ndi pakati?
Ayi. Mankhwala sayenera kugwiritsidwa ntchito ali ndi pakati.
Kodi ndingagwiritse ntchito Estrace kapena Premarin ndi mowa?
Kumwa mowa pamodzi ndi Estrace kapena Premarin kutha kuonjezera chiopsezo chanu za khansa ya m'mawere. Funsani akatswiri azachipatala anu kuti akupatseni malangizo pa zakumwa zoledzeretsa ndi matenda aliwonse omwe mungakhale nawo.
Kodi njira yabwino kwambiri ndi iti Premarin?
Estrace ndi njira yofananira ndi Premarin. Mankhwala ena omwe ali ndi estrogen ndi Vivelle Dot Patch, Climara Patch, kapena estrogen ya ukazi ngati mapiritsi a Vagifem ukazi (mapiritsi achikazi omwe amagwiritsidwa ntchito ndi mkazi) kapena Estring Vaginal Ring. Lankhulani ndi omwe amakuthandizani kuti muwone ngati imodzi mwa mankhwalawa ndi yoyenera kwa inu.
Kodi estrogen ndi estradiol ndizofanana?
Estradiol ndi mtundu wa estrogen, mahomoni achikazi. Zida zonse za estradiol ndi estrogen. Komabe, pali mitundu ina ya estrogen kuposa estradiol yokha. Mwachitsanzo, conjugated estrogens (Premarin) ndi mtundu wina wa estrogen.
Kodi Premarin imayambitsa dementia?
Premarin (ndi Estrace) ali ndi chenjezo lolembedwa pamatenda okhudzana ndi matenda amisala. Phunziro la WHI Memory lomwe talitchula pamwambapa lidapeza chiopsezo chowonjezeka chokhala ndi matenda amisala mwa amayi omwe atha msambo omwe amatenga estrogen okha kapena estrogen ndi progestin. Chifukwa chake, zomwe akufotokozazi zimalimbikitsa kuti estrogen, ngakhale itengedwa yokha kapena ndi progestin, iyenera kuperekedwa pamlingo wotsikitsitsa komanso kwakanthawi kochepa.
Kodi Estrace imakulitsa milingo ya estrogen?
Estrace (ndi Premarin) amachulukitsa kuchuluka kwa estrogen. Ngakhale mu mawonekedwe a chikazi, pali mayamwidwe amachitidwe, ndipo milingo ya estrogen imakulira. Wothandizira zaumoyo wanu amatha kudziwa kuti ndi chinthu chiti chomwe chili choyenera kwa inu.
