Waukulu >> Mankhwala Osokoneza Bongo Vs. Mnzanu >> Metoprolol vs. atenolol: Kusiyana, kufanana, ndi zomwe zili zabwino kwa inu

Metoprolol vs. atenolol: Kusiyana, kufanana, ndi zomwe zili zabwino kwa inu

Mankhwala osokoneza bongo Vs. Mnzanu

Metoprolol ndi atenolol amagwiritsidwa ntchito pochiza mitundu yosiyanasiyana yazokhudzana ndi mtima kuphatikiza angina pectoris ndi matenda oopsa, kapena kuthamanga kwa magazi. Angina pectoris amatanthauza komwe mumamva kupweteka pachifuwa kapena kusapeza bwino komwe kumachitika chifukwa mtima wanu sulandila magazi okwanira okosijeni. Izi zitha kuchitika nthawi yapanikizika kapena kuyeserera. Matenda oopsa amatanthauza kukhala ndi kuthamanga kwa magazi komwe magazi omwe amayenda m'mitsempha yanu amakhala okwera kwambiri kuposa kuthamanga kwanthawi zonse.

Metoprolol ndi atenolol ali mgulu lomwelo la mankhwala ndipo amathandiziranso chimodzimodzi, koma palinso kusiyana pakati pa mankhwalawa, ndipo tikambirana za awa.

Kodi pali kusiyana kotani pakati pa metoprolol ndi atenolol?

Metoprolol ndi mankhwala okhawo omwe amadziwika kuti ndi a beta-1-selective adrenergic agonist, otchedwa beta blockers. Beta 1 receptors amathandizira kukondoweza kwa mtima komwe kumawonjezera kugunda kwa mtima ndikutsika kwamphamvu kwa minofu yamtima. Kuletsa mapulogalamuwa, monga metoprolol, kumapangitsa kugunda kwa mtima pang'onopang'ono komanso kusamvana pang'ono. Metoprolol ndiyosangalatsa mtima kutanthauza kuti imangowonjezera zolandilira za beta 1 mumtima, ndipo sizimakhudza mitundu ina ya zolandilira za beta zomwe zimapezeka mthupi lonse, monga momwe mumayendera.

Metoprolol imapezeka m'mapiritsi otulutsidwa mwachangu mu 25 mg, 37.5 mg, 50 mg, 75 mg, ndi mapiritsi a 100 mg. Kutulutsidwa komweku kumadziwikanso kuti metoprolol tartrate. Njira yotulutsira metoprolol, yotchedwa metoprolol succinate, imapezeka mu mphamvu za 25 mg, 50 mg, 100 mg, ndi 200mg. Ma capsule otulutsidwa otalikirapo amapezeka mofanana ndi mapiritsi. Palinso njira ya 1 mg / ml ya jakisoni komanso ufa wamlomo. Hafu ya moyo wa metoprolol tartrate ili pafupifupi maola atatu, ndipo theka la metoprolol succinate pafupifupi maola asanu ndi awiri. Izi zikutanthauza kuti kupangika kwakumasulidwa sikuyenera kuikidwa pafupipafupi.

Atenolol ndi mankhwala omwe amalembedwa ngati beta-1-adrenergic agonist. Imagwira ntchito mofananamo ndi metoprolol mthupi. Hafu ya moyo wa atenolol ndi pafupifupi maola asanu ndi limodzi kapena asanu ndi awiri, chifukwa chake amatha kupitirira nthawi yayitali kuposa metoprolol. Atenolol imapezeka mu 25 mg, 50 mg, ndi mapiritsi 100 mg.

Kusiyana kwakukulu pakati pa metoprolol ndi atenolol
	Zamgululi	Atenolol
Gulu la mankhwala osokoneza bongo	Cardioselective beta-1-selective adrenergic agonist (beta blocker)	Cardioselective beta-1-selective adrenergic agonist (beta blocker)
Chizindikiro cha Brand / generic	Zolemba ndi generic zilipo	Zolemba ndi generic zilipo
Kodi dzina lake ndi ndani?	Lopressor, Toprol XL	Tenormin
Kodi mankhwalawa amabwera mwa mawonekedwe ati?	Mapiritsi am'kamwa omwe amatulutsidwa nthawi yomweyo komanso otalikitsa, makapisozi ojambulidwa, ufa wakamwa	Mapiritsi amlomo otulutsidwa nthawi yomweyo
Kodi mulingo woyenera ndi uti?	50 mg kawiri pa tsiku	50 mg kamodzi patsiku
Kodi mankhwalawa amatenga nthawi yayitali bwanji?	Nthawi yayitali	Nthawi yayitali
Ndani amagwiritsa ntchito mankhwalawa?	Ana ndi akulu	Ana ndi akulu

Zomwe zimathandizidwa ndi metoprolol ndi atenolol

Metoprolol ndi atenolol zonsezi zimagwiritsidwa ntchito pochiza angina pectoris ndi matenda oopsa. Zitha kugwiritsidwa ntchito mu angina wokhazikika, wolimba kapena angina wosakhazikika. Matenda a angina okhazikika, okhazikika amapezeka mosadukiza mukamalimbikira thupi kapena mukapanikizika kwambiri. Angina wosakhazikika samadziwikiratu ndipo atha kuchitika ngakhale atapuma.

Pogwiritsidwa ntchito pochiza matenda oopsa, metoprolol ndi atenolol zitha kugwiritsidwa ntchito zokhazokha kapena kuphatikiza mankhwala ena oletsa kuthamanga kwa magazi. Mankhwalawa akagwiritsidwa ntchito pokonza chithandizo cha infarction yogwira mtima, yokayikiridwa, kapena yotsimikizika, kapena matenda amtima, amakhala m'gulu la mankhwala osokoneza bongo omwe amathanso kuphatikizira ma enzyme inhibitors (ACE inhibitors) a angiotensin ndi ma diuretics. Mu ischemic myocardial matenda, beta blockers amachepetsa kufunika kwa mpweya wa myocardial minofu ndipo amakhala ndi antiarrhythmic.

Metoprolol ndi atenolol nawonso amagwiritsidwa ntchito polemba zilembo zina. Kugwiritsa ntchito kopanda zilembo kumatanthauza kugwiritsa ntchito ngati chisonyezo chomwe sichinavomerezedwe ndi Food and Drug Administration (FDA). Amagwiritsidwa ntchito pothandiza kupewa mutu waching'alang'ala ndi kuwongolera kunjenjemera.

Izi sizingakhale mndandanda wathunthu wazomwe angagwiritse ntchito mankhwalawa. Ndi dokotala wanu kapena katswiri wazamtima yekha yemwe angasankhe ngati imodzi mwa mankhwalawa ndi oyenera matenda anu.

Mkhalidwe	Zamgululi	Atenolol
Angina pectoris (kuphatikiza angina wodwala, wolimba, angina wosakhazikika)	Inde	Inde
Matenda oopsa	Inde	Inde
Mtima kulephera	Inde	Ayi
Mnyewa wamtima infarction	Inde	Inde
Kuchepetsa kugunda kwa mtima mu fibrillation ya atrial kapena flutter atrial	Kutumiza	Kutumiza
Kugwedezeka	Kutumiza	Kutumiza
Migraine prophylaxis	Kutumiza	Kutumiza
Paroxysmal supraventricular tachycardia prophylaxis	Ayi	Kutumiza
Kuchotsa mowa	Ayi	Kutumiza

Kodi metoprolol kapena atenolol ndiyothandiza kwambiri?

Metoprolol ndi atenolol aphunziridwa ndikuyerekeza kwambiri pazisonyezo ndi zotsatira zosiyanasiyana. A kusanthula meta yofalitsidwa mu 2017 idawunika momwe kuyerekezera kwa ma beta awiriwa kumayendera limodzi ndi propranolol ndi oxprenolol poyang'ana zotsatira za mayesero angapo azachipatala. Metoprolol idawonetsa kuchepa kwakukulu kwa chiopsezo cha kufa kwamtima poyerekeza ndi atenolol. Metoprolol adawonetsanso kuchepa kwazomwe zimayambitsa kufa ndi matenda amtima. Atayesedwa kuti achepetse chiopsezo cha sitiroko, metoprolol idatsimikiziranso kuti ndiyabwino kuposa atenolol. Pali deta zomwe zikusonyeza kuti mankhwala onsewa ndi othandiza poyerekeza ndi placebo ndipo palibe kusiyana kwakukulu pakati pa atenolol ndi metoprolol potengera kuthekera kwawo kuwongolera kuthamanga kwa magazi (kuthamanga kwa magazi).

Zamgululi awonetsedwa kuti amachepetsa kuthamanga kwa magazi kwa systolic komanso diastolic. Atenolol zingakhudze kuthamanga kwa magazi kuposa systolic, makamaka munthawi yogwira ntchito.

Kutengera izi, dokotala wanu atha kusankha kuyamba ndi metoprolol poyamba posankha wothandizila. Ndi dokotala wanu yekha yemwe angadziwe ngati chithandizo cha beta blocker ndi choyenera kwa inu.

Kuphunzira ndi kuyerekezera mtengo wa metoprolol vs. atenolol

Metoprolol ndi mankhwala akuchipatala omwe amapangidwa ndi mapulani a inshuwaransi yamalonda ndi Medicare. Ngati mumalipira ndalama pamankhwala a metoprolol, mutha kulipira pafupifupi $ 31 pamwezi umodzi. SingleCare imapereka coupon yomwe ingakuthandizeni kulipira mozungulira $ 4 ya metoprolol.

Atenolol ndi mankhwala akuchipatala omwe amapangidwa ndi mapulani a inshuwaransi yamalonda ndi Medicare. Popanda inshuwaransi, mutha kulipira mozungulira $ 30 patsiku la 30 la mapiritsi a 50 mg. Ndi khadi yosungira kuchokera ku SingleCare, mutha kulipira pafupifupi $ 9 pamankhwala awa.

	Zamgululi	Atenolol
Nthawi zambiri amakhala ndi inshuwaransi?	Inde	Inde
Nthawi zambiri amakhala ndi Medicare Part D?	Inde	Inde
Kuchuluka	60, 50 mg mapiritsi	30, 50 mg mapiritsi
Wopanga Medicare wamba	$ 0- $ 9	$ 0- $ 10
Mtengo wosakwatiwa	$ 4- $ 22	$ 9- $ 25

Zotsatira zoyipa za metoprolol vs. atenolol

Oseketsa beta beta monga metoprolol ndi atenolol amachepetsa momwe mtima umagunda komanso mphamvu yomwe imagunda. Kuchepetsa kugunda kwa mtima kumatha kubweretsa bradycardia, kapena kugunda kwa mtima. Pamene mtima sukugunda mwamphamvu, nthawi zina magazi samafika kumapeto ndi kukakamizidwa komwe tikufuna, zomwe zimapangitsa kumapeto komwe kumatha kukhala kozizira kukhudza.

Kutaya magazi mopanda mphamvu komanso kuchepa kwamitsempha yamagazi kumatha kubweretsanso mavuto ena monga postural hypotension, kumverera mopepuka komanso kuzunguliridwa mutayimirira mutakhala kapena kugona pansi. Mutu ukhozanso kupezeka mwa odwala omwe atenga metoprolol ndi atenolol.

Izi sizitanthauza kukhala mndandanda wathunthu wazovuta. Chonde funsani wamankhwala kapena dokotala wanu kuti mumve nawo mndandanda wathunthu.

	Zamgululi	Atenolol
Zotsatira zoyipa	Zoyenera?	Pafupipafupi	Zoyenera?	Pafupipafupi
Kutopa	Inde	Osati lipoti	Inde	0.6%
Chizungulire	Inde	Osati lipoti	Inde	4%
Matenda okhumudwa	Inde	Osati lipoti	Inde	0.6%
Mutu	Inde	Osati lipoti	Ayi	n / A
Kupuma pang'ono	Inde	Osati lipoti	Inde	0.6%
Bradycardia	Inde	Osati lipoti	Inde	3%
Kuzizira kozizira	Inde	Osati lipoti	Ayi	n / A
Kutengeka	Inde	Osati lipoti	Inde	awiri%
Kutentha	Inde	Osati lipoti	Ayi	n / A
Kutsekula m'mimba	Inde	Osati lipoti	Inde	awiri%
Nseru	Inde	Osati lipoti	Inde	4%
Kutupa	Inde	Osati lipoti	Ayi	n / A

Gwero: Metoprolol ( Tsiku ndi Tsiku Atenolol ( Tsiku ndi Tsiku )

Kuyanjana kwa mankhwala a metoprolol vs. atenolol

Digoxin ndi beta blockers monga metoprolol ndi atenolol iliyonse imakhudza kulimba kwa zopindika ndi kugunda kwa mtima. Akaperekedwa limodzi, odwala amakhala pachiwopsezo chowonjezeka cha bradycardia ndi hypotension. Kugunda kwa mtima, kuthamanga kwa magazi, ndi zizindikilo zina zakusokonekera kwa mtima ziyenera kuyang'aniridwa pafupipafupi ngati ziyenera kuperekedwa limodzi.

Metoprolol ndi Atenolol kuphatikiza ma calcium channel blocker monga amlodipine atha kuyambitsa kuchepa kowonjezera kwa mgwirizano wamtima womwe ungakhale wowopsa. Ngati kuphatikiza kuli kofunikira, ndikofunikira kupeza miyezo yoyambira momwe ntchito ikuyendera ndikukhala ndi kutsatira mosasinthasintha.

Mankhwala opatsirana pogonana monga fluvoxamine, clomipramine, ndi serotonin reuptake inhibitors (SSRIs) omwe amaletsa michere (CYP2D6) yomwe imayambitsa kagayidwe kake ka metoprolol. Mukapatsidwa concomitantly ndi metoprolol, mankhwalawa amatha kubweretsa kuwonjezeka kwa magazi a metoprolol. Izi zitha kubweretsa zotsatira zowonjezereka ndi metoprolol pamatenda amtima.

Izi sizitanthauza kuti pakhale mndandanda wokhudzana ndi mayanjano omwe angakhalepo ndi mankhwala. Muyenera kufunsa akatswiri azachipatala kuti mupeze mndandanda wathunthu.

Mankhwala osokoneza bongo	Gulu la mankhwala osokoneza bongo	Zamgululi	Atenolol
Onaninso Clonidine Methyldopa	Otsutsa a Alpha adrenergic	Inde	Inde
Selegiline Phenelzine Isocarboxazid	Monoamine oxidase inhibitors (MAOIs)	Inde	Inde
Digoxin	Digitalis glycosides / antiarrhythmic	Inde	Inde
Amlodipine Nifedipine Diltiazem Kutumiza	Oletsa ma calcium	Inde	Inde
Fluvoxamine Clomipramine Desipramine	Mankhwala opatsirana	Inde	Ayi
Fluoxetine Paroxetine Sertraline	Kusankha serotonin reuptake inhibitors (SSRIs)	Inde	Ayi
Hydralazine	Vasodilator	Inde	Inde
Dipyridamole	Platelet inhibitor	Inde	Inde
Ergotamine Dihydroergotamine	Ma alkaloid opunduka	Inde	Inde

Machenjezo a metoprolol ndi atenolol

Beta blockers amayambitsa kukhumudwa kwamatenda amtima. Odwala ena omwe ali ndi ziwopsezo zina, izi zitha kupangitsa kuti mtima ulephereke. Izi zikachitika, kulephera kwa mtima kuyenera kuthandizidwa malinga ndi malangizo apano.

Ma Beta blockers sayenera kuyimitsidwa mwadzidzidzi, makamaka kwa odwala omwe ali ndi matenda amitsempha. Matenda a mtima ndi ma ventricular arrhythmias adanenedwa mwa odwala omwe amasiya mwadzidzidzi ma beta blockers.

Ngati kuli kotheka, othandizira ma beta ayenera kupewedwa mwa odwala omwe ali ndi matenda a bronchospastic, monga asthma. Kugwiritsanso ntchito nthawi imodzi kumatha kukulitsa matenda amtundu. Ngati kuli kofunikira kugwiritsa ntchito beta blockers, mtima umasankhidwa. Kugwiritsa ntchito ma beta blockers osagwira mtima, monga carvedilol, sikuvomerezeka.

Atenolol dosing iyenera kuchepetsedwa kwa odwala omwe ali ndi matenda aimpso kapena kuwonongeka kwa impso popeza kutuluka kwa mankhwala kumachedwa.

Kuwongolera kosasintha mayesero azachipatala lofalitsidwa ndi The Lancet akuwonetsa kuti odwala omwe amachitidwa opareshoni ali pa beta blockers (metoprolol makamaka) ali pachiwopsezo chowonjezeka chazotsatira zoyipa monga matenda amtima kapena sitiroko. Komabe, sikulangizidwa kuti musiye beta-blocker kuti achite opaleshoni ngati wodwala wakhazikika pa iyo.

Ndikofunika kudziwa kuti zingakhale zovuta kuzindikira zizindikiro za hypoglycemia mwa odwala matenda ashuga, monga tachycardia, chifukwa amabisala ndi zomwe beta blocker imachita.

Chizungulire ndi hypotension zomwe zimayambitsidwa ndi metoprolol ndi atenolol zitha kuwonjezera ngozi komanso kuchuluka kwa kugwa, komwe kumatha kukhala koopsa kapena kuchititsa kuvulala kwamutu. Chenjezo liyenera kutengedwa kwa achikulire omwe ali pachiwopsezo chowonjezeka chakugwa.

Ndi dokotala wanu yekhayo amene angasankhe ngati mankhwala a metoprolol kapena atenolol ali otetezeka kwa inu.

Mafunso omwe amafunsidwa pafupipafupi za metoprolol vs. atenolol

Kodi metoprolol ndi chiyani?

Metoprolol ndi mankhwala akuchipatala omwe amadziwika kuti ndi beta blocker. Zimagwira ntchito yothana ndi matenda a kuthamanga kwa magazi ndi angina pochepetsa kugunda kwa mtima komanso kukakamira kwamatenda amtima. Amapezeka m'mapiritsi apakamwa omwe amatulutsidwa mwachangu, mapiritsi otulutsidwa ndi makapisozi, yankho la jakisoni, ndi ufa wamkamwa.

Kodi atenolol ndi chiyani?

Atenolol ndi beta blocker yoteteza mtima yomwe imapezeka potsatira dongosolo la mankhwala. Zimagwira ntchito yothana ndi matenda a kuthamanga kwa magazi ndi angina pochepetsa kugunda kwa mtima komanso kukakamira kwamatenda amtima. Amapezeka pamapiritsi otulutsa pakamwa nthawi yomweyo.

Kodi metoprolol ndi atenolol ndizofanana?

Metoprolol ndi atenolol ndi omwe amateteza beta pamtima, ndipo mankhwala omwe amagwirira ntchito amafanana, koma si ofanana kwenikweni. Metoprolol ili ndi mitundu iwiri yomwe ilipo, imodzi yochita mwachidule komanso imodzi yayitali, ndipo atha kumulidwa kamodzi kapena kawiri tsiku lililonse kutengera kapangidwe kake. Metoprolol imakhalanso lipophilic, kutanthauza kuti imakonda kusungunuka m'malo okhala ndi mafuta ambiri (lipid). Pachifukwa ichi, kutenga Metoprolol ndi chakudya nthawi zambiri kumalimbikitsidwa. Atenolol amathiridwa kamodzi tsiku lililonse ndipo ndi hydrophilic. Atenolol imasungunuka m'malo amadzimadzi, motero imangofunika kumwedwa ndi kapu yamadzi.

Kodi metoprolol kapena atenolol ndibwino?

Zambiri zikuwonetsa kuti mankhwala awiriwa amakhala ndi zotsatira zofananira kwa odwala omwe ali ndi matenda oopsa, komabe zotsatira zamatenda amtsogolo, monga kuchepa kwa matenda, zitha kukhala zabwino ndi metoprolol.

Kodi nditha kugwiritsa ntchito metoprolol kapena atenolol ndili ndi pakati?

Metoprolol ili m'gulu la Mimba C. Palibe maphunziro oyang'aniridwa bwino kuti akhazikitse chitetezo pathupi. Funsani dokotala wanu za kutenga Metoprolol pamene muli ndi pakati kapena mukuyamwitsa. Atenolol ili m'gulu la Mimba D. Ndi yotsutsana ndipo sayenera kutengedwa panthawi yapakati. Funsani dokotala pazomwe mungachite mukamakonzekera kutenga pakati kapena poyamwitsa.

Kodi ndingagwiritse ntchito metoprolol ya atenolol ndi mowa?

Ngakhale kulibe kulumikizana mwachindunji pakati pa mowa ndi beta blockers monga metoprolol ndi atenolol, kumwa mowa kumayambitsa kuthamanga kwa magazi. Kuphatikizika kwa mankhwala ndi mowa kumatha kukuika pachiwopsezo chokomoka kapena kugwa ndikudzivulaza.