Tamiflu vs. Xofluza: Kusiyana, kufanana, ndi iti yomwe ili yabwino kwa inu
Mankhwala osokoneza bongo Vs. MnzanuKuwunika kwa mankhwala osokoneza bongo & kusiyana kwakukulu | Zinthu zothandizira | Mphamvu | Kuphunzira inshuwaransi ndi kufananiza mtengo | Zotsatira zoyipa | Kuyanjana kwa mankhwala | Machenjezo | FAQ
Ikafika nthawi yanthawi ya chimfine, ndibwino kuti mukhale okonzeka kudziwa zomwe mungasankhe. Kuphatikiza pakupeza chimfine chimawombera chaka chilichonse , yomwe imalimbikitsidwa kwambiri, pali mankhwala omwe mungapezeke ngati mungatsike ndi chimfine . Mankhwalawa amatha kuthandiza kuchepetsa komanso kutalika kwa zizindikilo za chimfine monga kupweteka mutu, kutentha thupi, kutopa, komanso kupweteka kwa minofu kapena molumikizana.
Mankhwala awiri ovomerezeka a chimfine ndi Tamiflu (oseltamivir) ndi Xofluza (baloxavir marboxil). Ngakhale mankhwala onsewa amatha kuchiza chimfine, zimagwira ntchito m'njira zosiyanasiyana ndipo zimakhala ndi zovuta zina. Werengani kuti mudziwe momwe mankhwalawa amafananira.
Kodi pali kusiyana kotani pakati pa Tamiflu ndi Xofluza?
Tamiflu ndilo dzina la oseltamivir, lomwe linavomerezedwa mu 1999. Imagwira ngati neuraminidase inhibitor (NAI) yomwe imaletsa kutulutsa kachilombo ka chimfine m'maselo omwe ali ndi kachilomboka. Pochita izi, amachepetsa kufalikira kwa kachilomboka mthupi lonse. Tamiflu nthawi zambiri amapatsidwa kawiri tsiku lililonse kwa masiku asanupochiza fuluwenza. Itha kugwiritsidwanso ntchito popewa chimfine (prophylaxis).
Xofluza ndi dzina la baloxavir marboxil, lomwe lidavomerezedwa posachedwa mu 2018. Mankhwala atsopanowa amagwira ntchito ngatipolymerase acidic (PA)endonuclease inhibitor yomwe imaletsa kachilomboka kuti isadzipange yokha. Mwanjira imeneyi, Xofluza imagwira ntchito mosiyana poyerekeza ndi mankhwala ena opha ma virus monga Tamiflu (oseltamivir) ndi Relenza (zanamivir). Mankhwalawa amangofunika kumwedwa kamodzi ngati mlingo umodzi wokha kuti athetse kapena kuteteza flue.
| Kusiyana kwakukulu pakati pa Tamiflu vs. Xofluza | ||
|---|---|---|
| Tamiflu | Xofluza | |
| Gulu la mankhwala osokoneza bongo | Mavairasi oyambitsa Chithandizo cha Neuraminidase | Mavairasi oyambitsa Polymerase acidic (PA) endonuclease inhibitor |
| Chizindikiro cha Brand / generic | Mtundu wa generic ulipo | Mtundu wa generic sikupezeka pakadali pano |
| Kodi dzina lachibadwa ndi liti? | Oseltamivirmankwala | Baloxavir marboxil |
| Kodi mankhwalawa amabwera mwa mawonekedwe ati? | Piritsi lapakamwa Ufa kuyimitsidwa m'kamwa | Piritsi lapakamwa |
| Kodi mulingo woyenera ndi uti? | Chithandizo cha fuluwenza: Zaka 13 kapena kupitirira: 75 mg kawiri tsiku lililonse kwa masiku 5 1 mpaka 12 wazaka: Mlingo umadalira kulemera, kawiri tsiku lililonse kwa masiku asanu Masabata awiri osakwana chaka chimodzi: 3 mg / kg kawiri tsiku lililonse kwa masiku 5 Kupewa fuluwenza: Zaka 13 kapena kupitilira: 75 mg kamodzi tsiku lililonse kwa masiku osachepera 10 1 mpaka 12 wazaka: Mlingo umadalira kulemera, kamodzi tsiku lililonse kwa masiku 10 | Kuchiza kapena kupewa fuluwenza: Zaka 12 kapena kupitilira thupi lolemera 90 mpaka 180 lbs (40 mpaka 80 kg): Mapiritsi awiri a 20 mg omwe amatengedwa limodzi ngati mlingo umodzi wa 40 mg wazaka 12 kapena kupitilira ndi kulemera kwa 175 lbs (80 kg): Mapiritsi awiri a 40 mg amatengedwa pamodzi ngati 80 mg |
| Kodi mankhwalawa amatenga nthawi yayitali bwanji? | Chithandizo: Masiku 5 Kupewa: Masiku 10 * Njira zodzitetezera pakadwala zigawenga zimatha kukhala mpaka milungu isanu ndi umodzi | Kuchiza kapena kupewa: Tsiku limodzi lokhala ndi mlingo umodzi |
| Ndani amagwiritsa ntchito mankhwalawa? | Chithandizo: Masabata awiri azaka zakubadwa kapena kupitilira apo Kupewa: Chaka chimodzi kapena kupitilira apo | Kuchiza kapena kupewa: Azaka 12 zakubadwa kapena kupitilira apo |
Zomwe amathandizidwa ndi Tamiflu ndi Xofluza
Tamiflu ndi Xofluza onse amagwiritsidwa ntchito ngati chithandizo cha fuluwenza .Amakhala othandiza kwambiri akawapatsa chizindikiro choyamba komanso asanakumane ndi matendawa kwa maola opitilira 48. Onse Tamiflu ndi Xofluza amathanso kupewetsa chimfine mwa iwo omwe amalumikizana kwambiri ndi munthu yemwe ali ndi kachilomboka. Mankhwalawa atha kukhala othandiza makamaka kwa anthu omwe ali ndi chiopsezo chachikulu cha chimfine, monga omwe amakhala mdera lomwe likuphulika ndi ma virus kapena omwe ali ndi chitetezo chamthupi chazovuta chifukwa chazovuta zamankhwala.
Gwiritsani ntchito tebulo lotsatirali kuti mufanizire ntchito zovomerezeka zomwe Tamiflu ndi Xofluza amagwiritsa ntchito.
| Tamiflu | Xofluza | |
| Chithandizo cha Fuluwenza A / H1N1 | Inde | Inde |
| Chithandizo cha Fuluwenza A / H3N2 | Inde | Inde |
| Chithandizo cha Fuluwenza B. | Inde | Inde |
| Fuluwenza A / H1N1, fuluwenza A / H3N2, ndi fuluwenza B kupewa | Inde | Inde |
Kodi Tamiflu kapena Xofluza ndi yothandiza kwambiri?
Tamiflu ndi Xofluza onse ndi othandiza kuthana ndi ziwonetsero mwachangu kuposa momwe mungatengere placebo kapena osatinso chilichonse. Malinga ndi zoyeserera zamankhwala, Tamiflu ndi Xofluza adapezeka kuti amachepetsa zizindikilo mwachangu poyerekeza ndi placebo. Mu kuwunika kwachipatala ,poyerekeza ndi placebo, Tamiflu adapezeka kuti amachepetsa nthawi yakusintha kwa chizindikiro tsiku limodzi kapena awiri. Pamwala-1 mayesero ya Xofluza, poyerekeza ndi placebo, Xofluza anali ndi nthawi yayifupi yodziwitsa kupumula (kusiyana kwamaola 26.5).
Pamene Tamiflu ndi Xofluza adafaniziridwa ndi ina mayesero ,
Xofluza imawoneka ngati yothandiza kwambiri kuposa Tamiflu yokhala ndi nthawi yayifupi yosintha chizindikiro: maola 73 ndi Xofluza motsutsana ndi maola 81 ndi Tamiflu. Xofluza idafupikitsanso nthawi yakukhetsa ma virus, kapena kufalikira, mpaka maola 48 poyerekeza mpaka maola 96 ndi placebo kapena Tamiflu. Mlanduwu udalembetsa opitilira 2,000 ndikuphatikizira odwala azaka 12 kapena kupitilira apo.
MUhile Xofluza akuwoneka kuti ndiwothandiza kwambiri, kuthana ndi ma virus kwakhala vuto. Mu Japan ,Matenda ena a fuluwenza akuti samatha kulimbana ndi Xofluza, zomwe zimapangitsa kuti zisamayende bwino nthawi zina.
Kuphunzira ndi kuyerekezera mtengo wa Tamiflu vs. Xofluza
Tamiflu itha kugulidwa ndi mankhwala ndipo nthawi zambiri imakhala ndi inshuwaransi, Medicare, ndi Medicaid. Imapezeka m'mawonekedwe onse ndi generic. Kugulitsa kwamasiku khumi dzina la Tamiflu makapisozi kumatha kukhala pakati pa $ 155 mpaka $ 170 popanda inshuwaransi. Kupereka kwa masiku 10 makapisozi a oseltamivir atha kukhala pakati pa $ 20 ndi $ 50. Mutha kugwiritsa ntchito coupon ya SingleCare kuti musunge pa Tamiflu ku pharmacy yapafupi.
Xofluza imagulidwanso ndi mankhwala ndipo imakhala ndi inshuwaransi, Medicare, ndi Medicaid kutengera dongosolo. Imapezeka pokhapokha ngati dzina la mapiritsi. Ndalama zotulutsira mthumba za Xofluza zitha kukhala pakati pa $ 150 ndi $ 180. Onani ngati mungagwiritse ntchito coupon ya SingleCare kuti musunge pa Xofluza ku pharmacy yapafupi.
| Tamiflu | Xofluza | |
| Nthawi zambiri amakhala ndi inshuwaransi? | Inde, kutengera dongosolo | Inde, kutengera dongosolo |
| Nthawi zambiri amakhala ndi Medicare Part D? | Inde, kutengera dongosolo | Inde, kutengera dongosolo |
| Mlingo woyenera | 75 mg kawiri tsiku lililonse kwa masiku 5 | Mapiritsi awiri a 20 mg omwe amatengedwa pamodzi ngati mlingo umodzi wa 40 mg |
| Wopanga Medicare wamba | $ 10- $ 200 | $ 30- $ 170 |
| Mtengo wosakwatiwa | $ 30 | $ 160 |
Zotsatira zoyipa za Tamiflu vs. Xofluza
Tamiflu ndi Xofluza amakhala ndi zovuta zina monga mseru komanso kupweteka mutu. Kutengera kuyesedwa kwamankhwala, Tamiflu atha kukhala ndi zotulukapo zochulukirapo. Zotsatira zina zoyipa za Tamiflu zimaphatikizapo kusanza ndi kupweteka, malinga ndi chizindikiro kuchokera ku U.S. Food and Drug Administration. Zotsatira zina zoyipa za Xofluza zimaphatikizapo kutsegula m'mimba, kutupa kwamapapo (bronchitis), ndi kutukusira kwa sinusitis (sinusitis).
Tamiflu imatha kuyambitsa zovuta zina monga khungu kapena hypersensitivity reaction. Izi zimayamba ngati zotupa ndikuwonjezeka pakapita nthawi. Pakhala palinso malipoti a zochitika zamaganizidwe monga delirium, kuyerekezera zinthu m'maganizo, komanso zizolowezi mwa omwe amatenga Tamiflu.Zochitika zamaganizowa zanenedwa makamaka mwa ana ochokera ku Japan.
Xofluza amathanso kuyambitsa khungu kapena hypersensitivity reaction. Izi zimatha kuchitika ngati kufiira kapena kuyabwa. Palinso chiopsezo chotenga matenda a bakiteriya mukamamwa Xofluza.
| Tamiflu | Xofluza | |||
| Zotsatira zoyipa | Zoyenera? | Pafupipafupi | Zoyenera? | Pafupipafupi |
| Nseru | Inde | 8-10% | Inde | awiri% |
| Kusanza | Inde | 2-8% | Ayi | - |
| Mutu | Inde | 2-17% | Inde | 1% |
| Kutsekula m'mimba | Ayi | - | Inde | 3% |
| Matenda | Ayi | - | Inde | 3% |
| Sinusitis | Ayi | - | Inde | awiri% |
Gwero Tsiku ndi Tsiku (Tamiflu) , Tsiku ndi Tsiku (Xofluza) .
Kuyanjana kwa mankhwala a Tamiflu ndi Xofluza
Onse Tamiflu ndi Xofluza atha kulumikizana ndi Katemera wa chimfine - makamaka, katemera woteteza fuluwenza wamoyo. Chifukwa mankhwalawa ndi antivirals, amatha kukhudza momwe katemera wa chimfine amagwirira ntchito ndikuchepetsa mphamvu yake. Chifukwa chake, katemera wa fuluwenza sayenera kuperekedwa masiku 14 asanadutse kapena masiku awiri Tamiflu kapena Xofluza makonzedwe.
Xofluza amatha kulumikizana ndi mankhwala omwe ali ndi ma cation ambirimbiri. Mankhwalawa atha kuphatikizira mankhwala ofewetsa tuvi tolimba, maantacid, kapena zowonjezera zomwe zili ndi calcium, iron, magnesium, zinc, kapena selenium. Pogwiritsidwa ntchito ndi Xofluza, mankhwalawa amatha kuchepetsa kuchuluka kwa Xofluza mthupi ndikuchepetsa mphamvu yake.
| Tamiflu | Xofluza | |
| Katemera wa fuluwenza wamoyo | Inde | Inde |
| Mankhwala okhala ndi cation wopangidwa ndi polyvalent (zopangidwa ndi calcium, iron, magnesium, selenium, zinc, etc.) | Ayi | Inde |
Machenjezo a Tamiflu ndi Xofluza
Tamiflu iyenera kuyang'aniridwa mwa iwo omwe ali ndi mavuto a impso. Izi ndichifukwa choti kuwonongeka kwa impso kumatha kubweretsa kuchuluka kwa Tamiflu mthupi, zomwe zingayambitse zovuta.
Kutenga kwa Xofluza sikudziwika kuti kumakhudzidwa ndi ntchito ya impso. Kuphatikiza apo, chitetezo chake komanso mphamvu zake sizinaphunzirepo kwa omwe amalemera ochepera 40 kilogalamu.
Tamiflu ndi Xofluza sizovomerezeka kwa aliyense amene ali ndi ziwengo chifukwa cha zinthu zawo. Tamiflu ndi Xofluza sanaphunzire kwambiri ali ndi pakati. Kugwiritsa ntchito kwawo pathupi kuyenera kuwunikidwa ndi othandizira azaumoyo popeza maubwino ake akhoza kupitilira zovuta zomwe zingachitike.
Mafunso omwe amafunsidwa pafupipafupi okhudza Tamiflu vs. Xofluza
Tamiflu ndi chiyani?
Tamiflu (oseltamivir) ndi mankhwala ochepetsa tizilombo omwe amagwiritsidwa ntchito pochizira kapena kupewa chimfine. Imagwira ngati neuraminidase inhibitor yomwe imalepheretsa kufalikira kwa chimfine A ndi B mthupi. Kugwiritsa ntchito Tamiflu kumatha kufupikitsa nthawi yomwe zimatengera kuti chimfine zisinthe. Nthawi zambiri amatengedwa kawiri tsiku lililonse kwa masiku asanu.
Xofluza ndi chiyani?
Xofluza (baloxavir marboxil) ndi mankhwala omwe amatha kuchiza kapena kupewa chimfine. Ndi PA endonuclease inhibitor yomwe imayimitsa kachilombo ka fuluwenza kuti isadzitengere mthupi. Monga Tamiflu, imatha kufupikitsa nthawi yakusintha kwazizindikiro. Xofluza idapangidwa ndi Shionogi Pharma ndipo imaperekedwa ngati mlingo umodzizochizira chimfine kapena kupewa.
Kodi Tamiflu ndi Xofluza ndi ofanana?
Tamiflu ndi Xofluza onse ndi mankhwala opha ma virus. Koma sizofanana. Ngakhale onse amawongolera zizindikiro za chimfine, amagwira ntchito mosiyanasiyana ndipo amakhala ndi zovuta zina.
Kodi Tamiflu kapena Xofluza ndibwino?
Tamiflu ndi Xofluza onse ndi othandiza polimbana ndi kachilombo ka fuluwenza. Xofluza ndi mankhwala atsopano omwe awonetsedwa kuti amathandizira kuzizira chimfine mwachangu kuposa Tamiflu. Iyenso imangofunika kumwa ngati mlingo umodzi, womwe anthu ena angafune. Ndikofunika kukambirana njirazi ndi dokotala kuti mudziwe chithandizo chabwino kwambiri kwa inu.
Kodi nditha kugwiritsa ntchito Tamiflu kapena Xofluza ndili ndi pakati?
Palibe chidziwitso chokwanira chazachipatala chosonyeza kuti Tamiflu ndi Xofluza ali otetezeka mwa amayi apakati. Ngakhale umboni woti ungagwiritsidwe ntchito bwino pathupi ukusowa, maubwino awo atha kupitilira chiwopsezo cha matenda a fuluwenza. Funsani dokotala posankha mankhwala omwe mungagwiritse ntchito ngati muli ndi pakati.
Kodi ndingagwiritse ntchito Tamiflu kapena Xofluza ndi mowa?
Palibe zambiri pazolemba zamagulu omwe amafotokoza zomwe Tamiflu kapena Xofluza amachita ndi mowa. Komabe, kumwa mowa kumafooketsa chitetezo cha mthupi ndipo kumapangitsa kuti zikhale zovuta kulimbana ndi chimfine. Chifukwa chake, sikulimbikitsidwa kuti muzimwa mowa mukamadwala.
Kodi mungatenge Xofluza ndi Tamiflu?
Ayi. Sikoyenera kutenga Xofluza ndi Tamiflu limodzi. Mankhwalawa amaperekedwa ngati njira zingapo za chimfine. Kutengera mbiri yanu yazachipatala komanso mkhalidwe wanu wonse, mankhwala amodzi amatha kuperekedwa pamzake.
