Waukulu >> Mankhwala Osokoneza Bongo Vs. Mnzanu >> Atorvastatin vs. simvastatin: Kusiyana, kufanana, ndi zomwe zili zabwino kwa inu

Atorvastatin vs. simvastatin: Kusiyana, kufanana, ndi zomwe zili zabwino kwa inu

Atorvastatin vs. simvastatin: Kusiyana, kufanana, ndi zomwe zili zabwino kwa inuMankhwala osokoneza bongo Vs. Mnzanu

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Atorvastatin ndi simvastatin ndi mankhwala awiri ovomerezeka a statin omwe amachiza cholesterol. Dokotala wanu akhoza kukupatsani imodzi mwa mankhwalawa ngati muli ndi LDL (low-density lipoprotein) cholesterol, yomwe imadziwikanso kuti cholesterol yoyipa. Mwa kutsitsa cholesterol, atorvastatin kapena simvastatin zitha kuthandiza kuchepetsa chiopsezo cha matenda amtima komanso kupwetekedwa mtima.



Makamaka, atorvastatin ndi simvastatin amagwira ntchito ngati HMG-CoA reductase inhibitors. Poletsa ma enzyme a HMG-CoA reductase, awa zikondwerero amachepetsa kutulutsa kwa cholesterol m'chiwindi. Ndi cholesterol yochepetsetsa yomwe imazungulira m'magazi, thupi limatha kubwezeretsanso mafuta m'thupi ambiri ndikuchepetsa cholesterol yonse.

Atorvastatin ndi simvastatin atha kugwiranso ntchito m'njira zofananira koma ali ndi kusiyanasiyana kwamiyeso, kayendetsedwe kake, ndi zovuta zina zomwe zingachitike.

Kodi pali kusiyana kotani pakati pa atorvastatin ndi simvastatin?

Atorvastatin imadziwikanso ndi dzina lake, Lipitor, yomwe idavomerezedwa ndi FDA mu 1996. Mwa zina, imagwiritsidwa ntchito kuti ichepetse chiwopsezo cha matenda amtima kapena kupwetekedwa ndi omwe ali ndi mitima matenda .



Atorvastatin (Atorvastatin ndi chiyani?) Amakhala ndi theka la moyo wa maola 14. Mankhwalawa amagwira ntchito akangoyamwa, ndipo ntchito yake yotsitsa lipid imatha 20 mpaka 30 maola pambuyo pa kayendetsedwe. Pamodzi ndi rosuvastatin, kapena Crestor, atorvastatin ndi mankhwala amphamvu kwambiri kuposa ma statins ena monga simvastatin ndi pravastatin.

Atorvastatin imapezeka mu 10 mg, 20 mg, 40 mg, ndi mapiritsi a 80 mg. Mlingo woyambira ndi 10 kapena 20 mg kamodzi tsiku lililonse ngakhale kuti mulingo wokhazikika umatha kuyambira 10 mpaka 80 mg kamodzi tsiku lililonse. Atorvastatin akhoza kumwedwa nthawi iliyonse patsiku.

Simvastatin (Simvastatin ndi chiyani?) Imadziwikanso ndi dzina lake, Zocor. Poyerekeza ndi atorvastatin, simvastatin ndi mankhwala achikulire omwe FDA idavomerezedwa koyamba mu 1991. Monga ma statins ena, amagwiritsidwa ntchito pochepetsa chiopsezo cha matenda amtima ndi kupwetekedwa mtima kwa omwe ali ndimatenda amtima.



Mukufuna mtengo wabwino kwambiri pa simvastatin?

Lowani zidziwitso zamitengo ya simvastatin kuti mudziwe kuti mitengo isintha liti!

Pezani zidziwitso zamitengo

Mosiyana ndi atorvastatin, simvastatin ndi osokoneza bongo . Kutanthauza, siligwira ntchito mpaka itapukusidwa, kapena kukonzedwa, m'chiwindi. Ikakonzedwa, simvastatin imasandulika mawonekedwe ake, simvastatin acid, yomwe imakhala ndi theka la moyo kwa ola limodzi kapena awiri.



Simvastatin imapezeka mu mphamvu za 5 mg, 10 mg, 20 mg, 40 mg, ndi 80 mg. Mlingo woyambira woyambira ndi 10 kapena 20 mg kamodzi tsiku lililonse, ndipo mlingo wabwinobwino umatha kuyambira 5 mpaka 40 mg patsiku. Simvastatin tikulimbikitsidwa kuti titenge usiku.

Kusiyana kwakukulu pakati pa atorvastatin ndi simvastatin
Atorvastatin Simvastatin
Gulu la mankhwala osokoneza bongo HMG-CoA reductase inhibitor
Statin
HMG-CoA reductase inhibitor
Statin
Chizindikiro cha Brand / generic Ma brand ndi generic amapezeka Ma brand ndi generic amapezeka
Kodi dzina lake ndi ndani? Lipitor Zocor
Kodi mankhwalawa amabwera mwa mawonekedwe ati? Piritsi lapakamwa Piritsi lapakamwa
Kodi mulingo woyenera ndi uti? 10 mpaka 80 mg kamodzi tsiku lililonse 5 mpaka 40 mg kamodzi patsiku
Kodi mankhwalawa amatenga nthawi yayitali bwanji? Kuchiza ndi atorvastatin ndikutenga nthawi yayitali kuti muchepetse kuchuluka kwa mafuta m'thupi komanso kukhalabe pachiwopsezo chodwala matenda a mtima komanso sitiroko. Chithandizo cha simvastatin ndi chanthawi yayitali chothana ndi kuchuluka kwama cholesterol komanso kukhalabe pachiwopsezo chodwala matenda a mtima komanso sitiroko.
Ndani amagwiritsa ntchito mankhwalawa? Akuluakulu; ana ndi achinyamata azaka 10 mpaka 17 azaka zapakati pa heterozygous family hypercholesterolemia (HeFH) Akuluakulu; ana ndi achinyamata azaka 10 mpaka 17 azaka zapakati pa heterozygous family hypercholesterolemia (HeFH)

Zomwe zimathandizidwa ndi atorvastatin ndi simvastatin

Atorvastatin ndi simvastatin amagwiritsidwanso ntchito chimodzimodzi. Onsewa amathandizira cholesterol yambiri (hypercholesterolemia), kuchuluka kwa lipid (hyperlipoproteinemia), ndi milingo yayikulu ya triglyceride (hypertriglyceridemia). Nthawi yomweyo, ma statins amatha kuthandiza kuwonjezera cholesterol ya HDL, mtundu wa cholesterol wabwino womwe umakhala ndi zoteteza ku matenda amtima.



Atorvastatin ndi simvastatin zitha kuchepetsanso chiopsezo cha matenda amtima ndi kupwetekedwa motere:

  • Akuluakulu omwe alibe matenda amtima (CHD) omwe amakhala ndi ziwopsezo zingapo
  • Akuluakulu omwe ali ndi matenda amtundu wa Type 2 opanda CHD, koma omwe ali ndi zifukwa zingapo zoopsa
  • Akuluakulu omwe amapezeka ndi CHD

Zowopsa pazochitika zamtima zingaphatikizepo kuthamanga kwa magazi (kuthamanga kwa magazi) ndi shuga wambiri wamagazi (matenda ashuga).



Atorvastatin ndi simvastatin zitha kuchepetsa cholesterol komanso lipid mwa omwe ali ndi matenda a lipid , monga homozygous family hypercholesterolemia (HoFH). Ma statins amathanso kuchiza ana ndi achinyamata (azaka 10-17 zakubadwa) ndi heterozygous family hypercholesterolemia (HeFH).

Chithandizo cha atherosclerosis, kapena mafuta omwe amaikidwa pamakoma amitsempha yamagazi, ndi chifukwa china chomwe atorvastatin kapena simvastatin atha kulembedwera. Pochepetsa chikwangwani pamakoma amitsempha yamagazi, ma statins amatha kuthandiza kuchepetsa zizindikilo monga kupweteka pachifuwa (angina).



Mkhalidwe Atorvastatin Simvastatin
Matenda osokoneza bongo Inde Inde
Hyperlipoproteinemia Inde Inde
Hypertriglyceridemia Inde Inde
Matenda a mtima ndi kupewa sitiroko Inde Inde
Matenda a m'mimba Inde Inde

Kodi atorvastatin kapena simvastatin ndiyothandiza kwambiri?

Atorvastatin ndi simvastatin onse ndi mankhwala othandiza. Kafukufuku wasonyeza kuti iwo omwe amamwa mankhwala awo a statin osachepera 90% ya nthawiyo khalani ndi chiopsezo chochepera 45% chomwalira ndi matenda amtima, sitiroko, kapena chifukwa chilichonse. Kawirikawiri, ma statins ndi othandiza kwambiri pochepetsa mafuta m'thupi komanso kuchepetsa kuchuluka kwa matenda amtima komanso kupwetekedwa mtima.

Palibe mayesero olimba a mutu ndi mutu kuyerekeza atorvastatin ndi simvastatin zomwe zachitika. Komabe, atorvastatin amadziwika kuti ndi mankhwala amphamvu kuposa simvastatin. Mu kafukufuku wina waposachedwa , atorvastatin idapezeka kuti imathandizira kwambiri kutsitsa LDL cholesterol (LDL-C) kuposa simvastatin. Kafukufukuyu adalemba zotsatira kuchokera ku 50, mayesero azachipatala, ndikuyerekeza mankhwala ena a statin monga fluvastatin, pravastatin, rosuvastatin, ndi lovastatin. Rosuvastatin inali ndi mphamvu zochepetsera kuchuluka kwa LDL mu kafukufukuyu.

Mmodzi kuwunika mwatsatanetsatane , Kafukufuku 75 poyerekeza mankhwala a statin adayesedwa. Malinga ndi zotsatira zamagulu owerengera, kuchuluka kwa tsiku ndi tsiku kwa atorvastatin 10 mg kumatha kutsitsa LDL cholesterol ndi 30% -40% pomwe mlingo wa tsiku ndi tsiku wa simvastatin 10 mg ukhoza kutsitsa LDL cholesterol ndi 20% -30%. Komabe, zovuta zamankhwala zakusiyanaku mwina sizingakhale zofunikira.

Funsani wothandizira zaumoyo wanu kuti adziwe njira yabwino kwambiri yothandizira. Kuchita bwino kwa ma statins kutengera mbiri yakuchipatala ndi banja lanu, mwazinthu zina.

Kuphunzira ndi kuyerekezera mtengo wa atorvastatin vs. simvastatin?

Atorvastatin imapezeka ngati mankhwala achibadwa omwe nthawi zambiri amapezeka ndi Medicare ndi mapulani ena a inshuwaransi. Amayikidwa ngati piritsi ya tsiku ndi tsiku yomwe imatha kupezeka m'masiku 30 kapena masiku 90. Mtengo wamtengo wapakati wa atorvastatin utha kufika $ 250. Komabe, mtengo ukhoza kutsitsidwa mpaka $ 15 ndi coupon ya SingleCare atorvastatin.

Simvastatin imapezekanso ngati mankhwala achibadwa. Monga statin yodziwika bwino, simvastatin nthawi zambiri imakhala ndi Medicare ndi mapulani a inshuwaransi. Mtengo wapakati wogulitsa simvastatin ndi pafupifupi $ 470. Komabe, ndi khadi yotsitsa ya simvastatin, monga SingleCare, mutha kuyembekezera kulipira ndalama zosakwana $ 10 patsiku la 30 la mapiritsi a 20 mg kuma pharmacies omwe akutenga nawo mbali.

Atorvastatin Simvastatin
Nthawi zambiri amakhala ndi inshuwaransi? Inde Inde
Nthawi zambiri amakhala ndi Medicare Part D? Inde Inde
Mlingo woyenera 10 mg kamodzi tsiku lililonse (kuchuluka kwa 30) 20 mg kamodzi tsiku lililonse (kuchuluka kwa 30)
Wopanga Medicare wamba $ 0 mpaka $ 16 $ 0 mpaka $ 9
Mtengo wosakwatiwa $ 15 + $ 10 +

Pezani khadi yochotsera mankhwala

Zotsatira zoyipa za atorvastatin vs. simvastatin?

Zotsatira zoyipa kwambiri za ma statins, monga atorvastatin ndi simvastatin, zimaphatikizapo zovuta zam'mimba monga kutsegula m'mimba, kudzimbidwa, ndi nseru. Zotsatira zina zimaphatikizapo chizungulire ndi kutupa kwa manja, miyendo, kapena mapazi (edema). Ma Statin amathanso kupweteketsa minofu (myalgia) kapena kufooka kwa minofu (myopathy).

Kuopsa kwa kupweteka kwa minofu kumawonjezeka ndi kuchuluka kwa ma statins. Komabe, poyerekeza ndi atorvastatin, simvastatin amadziwika kuti ali pachiwopsezo chachikulu cha myalgia. Anthu ena amathanso kukhala ndi chibadwa cha myalgia kuchokera ku simvastatin. Ngakhale ma statin onse ali ndi chiopsezo chokonzera kupweteka kwa minofu ngati mbali ina, a FDA walephera kugwiritsa ntchito ya simvastatin mapiritsi a 80 mg chifukwa chowopsa.

Zotsatira zina zoyipa zimapezeka patebulopo.

Atorvastatin Simvastatin
Zotsatira zoyipa Zoyenera? Pafupipafupi Zoyenera? Pafupipafupi
Ululu wophatikizana Inde 7% Inde 0.1%
Kutsekula m'mimba Inde 7% Inde *
Kudzimbidwa Ayi - Inde awiri%
Kudzimbidwa Inde 5% Inde *
Nseru Inde 4% Inde 6%
Kupweteka kwa minofu Inde 4% Inde 4%
Matenda a mkodzo Inde 6% Inde 3%
Nasopharyngitis Inde 8% Ayi -
Chizungulire Inde * Inde 5%
Edema Inde * Inde 3%

* sananene
Pafupipafupi sizidalira zomwe zimayesedwa pamutu. Izi sizingakhale mndandanda wathunthu wazovuta zomwe zingachitike. Chonde onani dokotala wanu kapena wothandizira zaumoyo kuti mudziwe zambiri.
Gwero: DailyMed ( Atorvastatin ), Tsiku Lililonse ( Simvastatin )

Kuyanjana kwa mankhwala a atorvastatin vs. simvastatin

Atorvastatin ndi simvastatin zimakonzedwa makamaka m'chiwindi ndi enzyme ya CYP3A4. Mankhwala omwe amaletsa, kapena kutseka, enzyme iyi imatha kuyambitsa kuchuluka kwa atorvastatin kapena simvastatin m'magazi. Mukatengedwa ndi CYP3A4 inhibitor monga clarithromycin kapena itraconazole, atorvastatin imatha kubweretsa chiopsezo chowonjezeka cha kupweteka kwa minofu (myalgia) kapena kufooka kwa minofu (myopathy). Madzi amphesa ndi CYP3A4 inhibitor yomwe imatha kukulitsa atorvastatin ndi simvastatin. Kumbali inayi, mankhwala monga rifampin ndi carbamazepine ndi ma inducers a CYP3A4 omwe amachepetsa milingo ya atorvastatin ndi simvastatin mthupi.

Protease inhibitors, monga ritonavir ndi lopinavir, zimatha kuyambitsa kuchuluka kwama statins mthupi. MaseĊµera apamwamba m'magazi angapangitse chiopsezo chowonjezeka cha zotsatira zoyipa, kuphatikizapo myalgia. Mankhwala osokoneza bongo ndi niacin amathanso kuonjezera chiwopsezo cha myalgia akatengedwa ndi atorvastatin kapena simvastatin.

Kutenga atorvastatin ndi njira zakulera zakumwa kumatha kuyambitsa kuchuluka kwamagazi azamankhwala akulera.

Kutenga ma statin okhala ndi warfarin akuti apangitsa kuchuluka kwa warfarin komanso chiopsezo chowopsa chakutaya magazi. Komabe, atorvastatin ndi mwina sangasokoneze ndi zotsatira za warfarin.

Mankhwala osokoneza bongo Gulu la mankhwala osokoneza bongo Atorvastatin Simvastatin
Clarithromycin
Mankhwalawa
Chinthaka
Ketoconazole
Madzi amphesa
CYP3A4 zoletsa Inde Inde
Rifampin
Carbamazepine
Othandizira a CYP3A4 Inde Inde
Ritonavir
Lopinavir
Simeprevir
Darunavir
Protease zoletsa Inde Inde
Gemfibrozil
Fenofibrate
Amapanga Inde Inde
Niacin Antihyperlipidemic Inde Inde
Digoxin Mtima glycoside Inde Inde
Norethindrone
Ethinyl estradiol
Njira zolera zapakamwa Inde Ayi
Warfarin Wotsutsa Ayi Inde

Funsani katswiri wa zamankhwala pazinthu zina zomwe zingagwiritsidwe ntchito ndi mankhwala.

Machenjezo a atorvastatin ndi simvastatin

Onse atorvastatin ndi simvastatin amatha kuyambitsa zovuta zomwe zimakhudza kupweteka kwa minofu (myalgia) kapena kufooka kwa minofu (myopathy). Zikakhala zovuta kwambiri, ma statins amathanso kuyambitsa rhabdomyolysis, kapena kuwonongeka msanga kwa mafupa. Mtundu wosowa wa myopathy, wotchedwa immune-mediated necrotizing myopathy (IMNM) nawonso akuti umagwiritsidwa ntchito ndi statin.

Atorvastatin ndi simvastatin makamaka zimapukusidwa m'chiwindi. Chifukwa chake, kugwiritsa ntchito kwawo kumatha kuyambitsa zovuta zina m'magawo a enzyme ya chiwindi. Mavitamini a chiwindi ayenera kuyang'aniridwa panthawi yonse yamankhwala. Anthu omwe ali ndi matenda a chiwindi amayeneranso kuyang'aniridwa kapena kupewa ma statin palimodzi.

Atorvastatin ndi simvastatin ziyenera kupewedwa mwa amayi apakati ndi amayi omwe akuyamwitsa. Izi zimatha kukhala ndi chiopsezo chowonjezeka cha zopunduka zobadwa.

Mafunso omwe amafunsidwa pafupipafupi za atorvastatin vs. simvastatin?

Kodi atorvastatin ndi chiyani?

Atorvastatin, yemwenso amadziwika ndi dzina loti Lipitor, ndi mankhwala a statin omwe amagwiritsidwa ntchito kutsitsa cholesterol ndikuchepetsa chiopsezo cha matenda amtima ndi stroke. Mulingo wabwinobwino wa atorvastatin umakhala pakati pa 10 mpaka 80 mg patsiku. Atorvastatin amakhala ndi theka la moyo wa maola 14 ndipo amatha kumwedwa nthawi iliyonse masana.

Simvastatin ndi chiyani?

Simvastatin imadziwikanso ndi dzina lake, Zocor. Ndi mankhwala a statin omwe amachepetsa kuchuluka kwa mafuta m'thupi, omwe nawonso angathandize kuchepetsa chiwopsezo chodwala matenda amtima komanso kupwetekedwa mtima. Mulingo wabwinobwino wa simvastatin ndi asanu mpaka 40 mg patsiku. Simvastatin amakhala ndi theka lanthawi yayitali ndipo tikulimbikitsidwa kuti timwetsedwe madzulo.

Kodi atorvastatin ndi simvastatin ndizofanana?

Atorvastatin ndi simvastatin onse ali mgulu la mankhwala lotchedwa HMG-CoA reductase inhibitors, kapena ma statins. Onsewa amagwiritsidwa ntchito kutsitsa cholesterol cha LDL. Komabe, ali ndi zosiyana pamphamvu zomwe zilipo komanso momwe amatengedwa.

Kodi atorvastatin kapena simvastatin ndibwino?

Atorvastatin ndi simvastatin onse ndi mankhwala othandiza kutsitsa cholesterol yamagazi. Komabe, atorvastatin amadziwika kuti ndi statin wamphamvu kwambiri. Atorvastatin imatha nthawi yayitali mthupi ndipo imatha kumwa m'mawa kapena usiku. Simvastatin ali pachiwopsezo chachikulu cha kupweteka kwa minofu kapena kufooka kuposa atorvastatin, makamaka pamlingo waukulu. Dokotala woperekayo ndi amene adzasankhe statin yothandiza kwambiri pazochitika zilizonse.

Kodi nditha kugwiritsa ntchito atorvastatin kapena simvastatin ndili ndi pakati?

Atorvastatin ndi simvastatin siziyenera kugwiritsidwa ntchito panthawi yapakati. Mafuta a cholesterol amatha kuchuluka panthawi yomwe ali ndi pakati ndipo amafunikira kuthandizira mwana wosabadwayo. Chifukwa chake, palibe phindu kutenga ma statinswa panthawi yapakati. Zitha kupanganso vuto la fetus nthawi yapakati.

Kodi ndingagwiritse ntchito atorvastatin kapena simvastatin ndi mowa?

Malinga ndi akatswiri a zaumoyo , Kumwa mowa mosapitirira malire kumakhala kotetezeka pogwiritsa ntchito statin. Kumwa mowa kwambiri komwe kwadzetsa matenda a chiwindi ndipamene mavuto angabuke. Mavitamini a chiwindi ayenera kuyang'aniridwa nthawi yonse yothandizira ndi statin.

Ndi statin iti yomwe ili ndi zovuta zochepa?

Statins nthawi zambiri imakhala yotetezeka popanda zovuta zoyipa zochepa. Malinga ndi American Heart Association (AHA), maubwino ama statins kuposa chiopsezo chomwe chingakhalepo za zotsatira zoyipa. Komabe, ma statins ena, monga pravastatin ndi fluvastatin , akhoza kukhala ndi chiopsezo chochepa cha myalgia kuposa simvastatin ndi atorvastatin. Poyerekeza ndi ma statins omwe amaperekedwa m'munsi mwake, ma statin omwe ali ndi milingo yayikulu amatha kuyambitsa mavuto. Mwachitsanzo, mlingo wa 80 mg wa simvastatin uli pachiwopsezo chachikulu choyambitsa myalgia. Pachifukwa ichi, a FDA adachepetsa kuchuluka kwa simvastatin kokha kwa anthu ena.

Zotsatira zoyipa za atorvastatin ndizotani?

Zotsatira zoyipa zazitali zamankhwala amtundu wa statin zimatha kusiyanasiyana kutengera munthu. Kutalika zotsatira zoyipa za ma statins Zitha kuphatikizira kupweteka kwa minofu, kuwonongeka kwa chiwindi, kuchuluka kwa shuga m'magazi, komanso zovuta zokumbukira. Komabe, chiopsezo cha zotsatirapo zazitali chimakhala chochepa ngati mankhwalawo apatsidwa ndi kuperekedwa moyenera.

Kodi atorvastatin ndiyabwino impso zanu?

Mlingo wa atorvastatin sikuyenera kusintha kwa iwo omwe ali ndi vuto la impso. Mwa anthu ena omwe ali ndi vuto lalikulu la impso, kugwiritsa ntchito atorvastatin kumatha kuyang'aniridwa.

Ambiri, atorvastatin si owopsa impso. Komabe, kugwiritsa ntchito atorvastatin kumatha kubweretsa chiopsezo chowonjezereka cha rhabdomyolysis, chomwe chimatha kubweretsa kulephera kwa impso koopsa. Lankhulani ndi dokotala wanu ngati muli ndi vuto la impso musanayambe kugwiritsa ntchito mankhwala osokoneza bongo.