Glipizide vs. metformin: Kusiyana, kufanana, ndi zomwe zili zabwino kwa inu

Mankhwala osokoneza bongo Vs. Mnzanu

Kuwunika kwa mankhwala osokoneza bongo & kusiyana kwakukulu | Zinthu zothandizira | Mphamvu | Kuphunzira inshuwaransi ndikufanizira mtengo | Zotsatira zoyipa | Kuyanjana kwa mankhwala | Machenjezo | FAQ

Glipizide ndi metformin ndi mankhwala awiri omwe amagwiritsidwa ntchito pochizira mtundu wachiwiri wa shuga. Anthu omwe ali ndi matenda a shuga amtundu wa 2 ali ndi vuto la hormone insulin, yomwe imayambitsa kusuntha shuga (glucose) wamagazi m'maselo amthupi kuti akhale ndi mphamvu. Insulini ikakhala kuti siyigwiranso ntchito, kukana kwa insulin kumatha kukula ndikuwonjezera kuchuluka kwa shuga, komwe kumatha kubweretsa mavuto ena azaumoyo. Glipizide ndi metformin zitha kuthandiza kusungunuka kwa milingo yambiri ya shuga kuti ichepetse chiopsezo cha zovuta kuchokera ku shuga.

Poyerekeza ndi othandizira atsopano, glipizide ndi metformin ndi mankhwala otchipa ochepetsa matenda ashuga. Zonsezi zimagwiritsidwa ntchito poyang'anira kwa nthawi yayitali mtundu wa 2 shuga. Ngakhale ali ndi kufanana pazotsatira zake zonse, glipizide ndi metformin zimasiyana mosiyanasiyana, makamaka momwe amagwirira ntchito, zovuta zina, komanso kuyanjana kwa mankhwala.

Kodi pali kusiyana kotani pakati pa glipizide ndi metformin?

Glipizide

Glipizide ndi dzina lodziwika bwino la Glucotrol. Ndi gawo limodzi la mankhwala omwe amatchedwa sulfonylureas, ndipo amagwira ntchito kulimbikitsa kutulutsa kwa insulin kuchokera ku kapamba. Kuwonjezeka kwa insulini kumathandizira kutsitsa magazi m'magazi m'thupi.

Glipizide imapezeka ngati 5 mg kapena 10 mg piritsi yamlomo. Generic glipizide imabweranso m'mapiritsi otulutsa mphamvu mu 2.5 mg, 5 mg, ndi 10 mg. Glipizide nthawi zambiri amatengedwa kamodzi tsiku lililonse kadzutsa.

Metformin

Metformin ndi dzina lodziwika bwino la Glucophage kapena Riomet, ndipo ndi gulu la mankhwala otchedwa biguanides. Metformin imagwira ntchito yothandizira mtundu wachiwiri wa shuga ndi kuchepetsa kupanga shuga m'chiwindi ndi kuchepa mayamwidwe shuga m'matumbo. Zimathandizanso kukulitsa chidwi cha insulin ndikuwonjezera kuchuluka kwa shuga m'matumba amthupi.

Metformin imapezeka ngati piritsi pakamwa pamphamvu za 500 mg, 850 mg, ndi 1000 mg. Mapiritsi otulutsidwa a metformin amapezekanso ndipo adapangidwa kuti azitengedwa kamodzi tsiku lililonse. Kutulutsa msanga metformin nthawi zambiri amapatsidwa kuti azitengedwa kawiri tsiku lililonse.

Kusiyana kwakukulu pakati pa glipizide ndi metformin
	Glipizide	Metformin
Gulu la mankhwala osokoneza bongo	Sulfonylurea	Zamgululi
Chizindikiro cha Brand / generic	Ma brand ndi generic amapezeka	Ma brand ndi generic amapezeka
Kodi dzina lake ndi ndani?	Glucotrol	Glucophage Riomet
Kodi mankhwalawa amabwera mwa mawonekedwe ati?	Piritsi lapakamwa	Piritsi lapakamwa
Kodi mulingo woyenera ndi uti?	5 mg kamodzi tsiku lililonse musanadye chakudya cham'mawa. Mlingo ungasinthidwe malinga ndi kuyankha ndi matenda. Zolemba malire mlingo wa 40 mg pa tsiku.	500 mg kawiri tsiku lililonse kapena 850 mg kamodzi tsiku lililonse ndi chakudya. Mlingo ungasinthidwe malinga ndi kuyankha ndi matenda. Mlingo waukulu wa 2,550 mg patsiku.
Kodi mankhwalawa amatenga nthawi yayitali bwanji?	Kutalika kwakanthawi kasamalidwe ka matenda ashuga	Kutalika kwakanthawi kasamalidwe ka matenda ashuga
Ndani amagwiritsa ntchito mankhwalawa?	Akuluakulu azaka 18 kapena kupitilira apo	Akuluakulu ndi ana azaka 10 kapena kupitilira apo

Zomwe zimathandizidwa ndi glipizide ndi metformin

Glipizide ndi metformin onse ndi ovomerezeka ndi FDA kuti athetse mtundu wa 2 wa matenda ashuga. Kuchepetsa kuchuluka kwa shuga m'magazi kumatha kuchepetsa kuchepa kwa zovuta kuchokera ku matenda ashuga. Mavutowa atha kuphatikizira matenda amtima, matenda a impso, matenda a chiwindi, kuwonongeka kwamaso, ndi matenda am'mapazi.

Metformin nthawi zina amagwiritsidwa ntchito pochiza matenda ena, monga matenda ashuga, kapena matenda ashuga panthawi yapakati, komanso matenda a polycystic ovary (PCOS) . Metformin imagwiritsidwanso ntchito ngati cholembera kuti muchepetse kunenepa komwe kumachitika chifukwa cha mankhwala ena opatsirana pogonana.

Palibe maphunziro ofunikira omwe adachitapo pazogwiritsa ntchito glipizide.

Mkhalidwe	Glipizide	Metformin
Type 2 matenda a shuga	Inde	Inde
Matenda a shuga	Ayi	Kutumiza
Matenda a Polycystic ovary	Ayi	Kutumiza
Kulemera chifukwa cha mankhwala a antipsychotic	Ayi	Kutumiza

Kodi glipizide kapena metformin ndiyothandiza kwambiri?

Glipizide ndi metformin ndi mankhwala othandiza onse a shuga kuti athe kuchepetsa kuwongolera kwa anthu omwe ali ndi matenda ashuga amtundu wa 2. Zitha kugwiritsidwa ntchito ngati monotherapy kapena piritsi losakaniza lotchedwa Metaglip. Glipizide ndi metformin zimagwira ntchito bwino zikagwiritsidwa ntchito ndi zakudya zoyenera komanso masewera olimbitsa thupi.

Metformin amakhalabe mankhwala oyamba a mtundu wachiwiri wa shuga, malinga ndi malangizo ochokera ku Bungwe la American Diabetes Association (ADA) . Poyerekeza poyerekeza ndi omwe ali ndi matenda ashuga amtundu wa 2 komanso matenda amitsempha am'mitsempha, metformin imachepetsa chiopsezo chodwala matenda amtima komanso kupwetekedwa kuposa glipizide. Malinga ndi kafukufuku wakhungu kawiri, metformin adawonetsa zazikulu zotsatira za mtima kuposa glipizide pakatha zaka zisanu.

Wina kuyesa kofananako anapeza kuti metformin inapereka shuga wabwino kwambiri kuposa glipizide. Omwe amatenga metformin mu phunziroli anali ndi bwino kusala magazi m'magazi a glucose kuposa glipizide pambuyo pa 24, 36, ndi masabata 52. Omwe amatenga metformin analinso ndi otsika Mulingo wa HbA1c kuposa omwe amatenga glipizide pambuyo pa masabata 52. Metformin idapangitsa kuti muchepetse ndipo glipizide idapangitsa kuti omwe akutenga nawo mbali apindule nawo.

Funsani othandizira zaumoyo kuti akuthandizeni ngati angadwale matenda amtundu wachiwiri. Kutengera matenda anu onse, shuga m'magazi , ndi mankhwala ena omwe mukumwa, mankhwala amodzi akhoza kusankhidwa kuposa ena.

Mukufuna mtengo wabwino pa Glipizide?

Lowani zidziwitso zamitengo ya Glipizide ndikupeza kuti mitengo ikasintha liti!

Pezani zidziwitso zamitengo

Kuphunzira ndi kuyerekezera mtengo wa glipizide vs. metformin

Glipizide ndi mankhwala ochizira matenda a shuga omwe nthawi zambiri amapangidwa ndi Medicare ndi mapulani a inshuwaransi. Kuti mupeze glipizide, copay imatha kuyambira $ 0 mpaka $ 9. Mtengo wapakati wogulitsa glipizide ukhoza kukhala pafupifupi $ 30. Coupon ya singleCare glipizide itha kuthandiza kutsitsa mtengo mpaka $ 4 kuma pharmacies omwe akutenga nawo mbali.

Metformin ndi mankhwala omwe amalembedwa antidiabetic omwe amapezeka ndi Medicare komanso mapulani a inshuwaransi. Medicare copay wamba imatha kuyambira $ 0 mpaka $ 8, ndipo mtengo wogulitsa ukhoza kukhala pafupifupi $ 25 kutengera mankhwala omwe mukupitako. Coupon ya metformin yochokera ku SingleCare imatha kuchepetsa mtengo mpaka $ 4.

	Glipizide	Metformin
Nthawi zambiri amakhala ndi inshuwaransi?	Inde	Inde
Nthawi zambiri amakhala ndi Medicare Part D?	Inde	Inde
Mlingo woyenera	5 mg kamodzi patsiku (kuchuluka kwa mapiritsi 60)	500 mg kawiri tsiku lililonse (kuchuluka kwa mapiritsi 60)
Wopanga Medicare wamba	$ 0 mpaka $ 9	$ 0 mpaka $ 8
Mtengo wosakwatiwa	$ 4 +	$ 4 +

Zotsatira zoyipa za glipizide vs. metformin

Zotsatira zoyipa kwambiri za glipizide zimaphatikizapo shuga wambiri wamagazi ( hypoglycemia ), kudzimbidwa, kutsegula m'mimba, nseru, ndi chizungulire.

Zotsatira zoyipa kwambiri za metformin zimaphatikizapo kutsegula m'mimba, mseru, kufooka (asthenia), hypoglycemia, ndi mutu.

Zotsatira zoyipa za glipizide zimaphatikizapo hypoglycemia yoopsa ndi kuchepa kwa magazi m'thupi. Zotsatira zoyipa za metformin zimaphatikizapo lactic acidosis komanso kuchepa kwa vitamini B12. Funsani wothandizira zaumoyo pazinthu zina zomwe zingachitike chifukwa cha glipizide kapena metformin.

	Glipizide	Metformin
Zotsatira zoyipa	Zoyenera?	Pafupipafupi	Zoyenera?	Pafupipafupi
Matenda osokoneza bongo	Inde	*	Inde	1% –5%
Kudzimbidwa	Inde	*	Ayi	-
Kutsekula m'mimba	Inde	*	Inde	53%
Nseru	Inde	*	Inde	26%
Chizungulire	Inde	*	Ayi	-
Kufooka	Ayi	-	Inde	9%
Mutu	Inde	*	Inde	6%

* sananene
Pafupipafupi sizidalira zomwe zimayesedwa pamutu. Izi sizingakhale mndandanda wathunthu wazovuta zomwe zingachitike. Chonde onani dokotala wanu kapena wothandizira zaumoyo kuti mudziwe zambiri.
Gwero: DailyMed ( Glipizide ), Tsiku Lililonse ( Metformin )

Kuyanjana kwa mankhwala a glipizide vs. metformin

Glipizide ndi metformin amatha kulumikizana ndi mankhwala ofanana. Mankhwala ena amatha kuonjezera kutsika kwa shuga m'magazi chifukwa cha glipizide ndi metformin, zomwe zimatha kuwonjezera chiopsezo cha hypoglycemia. Mankhwalawa amaphatikizapo mankhwala ena a antidiabetic ndi ena ochepetsa kuthamanga kwa magazi monga ACE inhibitors ndi angiotensin type II receptor blockers.

Mankhwala ena amatha kuchepetsa momwe glipizide ndi metformin zimagwirira ntchito, zomwe zimatha kuchepetsa kutsika kwa shuga m'magazi. Mankhwalawa atha kuphatikiza calcium channel blockers, diuretics, corticosteroids, beta blockers, ndi njira zakulera zam'kamwa. Zizindikiro za hypoglycemia zimatha kubisidwa mukamamwa ma beta blockers, chifukwa chake amayenera kuyang'aniridwa ndi anthu omwe amamwa mankhwalawa.

Metformin amathanso kulumikizana ndi carbonic anhydrase inhibitors, monga topiramate ndi zonisamide, zomwe zimatha kuwonjezera chiopsezo cha lactic acidosis. Mankhwala ena monga ranolazine ndi vandetanib amatha kulumikizana ndi metformin ndikusokoneza kuchotsedwa kwa impso. Mankhwalawa amatha kukulitsa kuchuluka kwa metformin m'magazi ndikuwonjezera chiopsezo cha lactic acidosis.

Mankhwala osokoneza bongo	Gulu la mankhwala osokoneza bongo	Glipizide	Metformin
Topiramate Zonisamide Acetazolamide Dichlorphenamide	Mpweya wa anhydrase inhibitors	Ayi	Inde
Ranolazine	Zotsutsana	Ayi	Inde
Vandetanib	Tyrosine kinase inhibitors	Ayi	Inde
Insulini Sitagliptin Dulaglutide Dapagliflozin Miglitol	Maantibayotiki	Inde	Inde
Lisinopril Enalapril Wolemba	Zoletsa za ACE	Inde	Inde
MulembeFM Irbesartan Losartan	Angiotensin II olandila othandizira	Inde	Inde
Amlodipine Nicardipine Kutumiza	Oletsa ma calcium	Inde	Inde
Hydrocortisone Prednisone Methylprednisolone	Corticosteroids	Inde	Inde
Hydrochlorothiazide Chlorthalidone Indapamide Furosemide Bumetanide	Okodzetsa	Inde	Inde
Atenolol Bisoprolol Zamgululi	Oletsa Beta	Inde	Inde
Mankhwala osokoneza bongo Ethinyl estradiol Wotsogola Norethindrone	Estrogens ndi njira zakulera zam'kamwa	Inde	Inde

Funsani katswiri wa zamankhwala pazinthu zina zomwe zingagwiritsidwe ntchito ndi mankhwala

Machenjezo a glipizide ndi metformin

Chifukwa cha kuchepa kwa shuga, glipizide ndi metformin amakhala pachiwopsezo cha hypoglycemia, kapena shuga wotsika magazi. Chiwopsezo cha hypoglycemia chimawonjezeka glipizide kapena metformin ikatengedwa ndi othandizira ena. Kuchita masewera olimbitsa thupi kwakanthawi komanso kumwa mowa kumawonjezeranso ngozi imeneyi. Zizindikiro za hypoglycemia zimaphatikizapo mantha, thukuta, kugunda kwamtima, komanso kusokonezeka.

Anthu ena omwe ali ndi vuto la kusowa kwa glucose 6-phosphate dehydrogenase (G6PD) ali pachiwopsezo chokhala ndi kuchepa kwa magazi m'thupi mukamamwa glipizide. Komabe, anthu ena opanda vuto la GP6D amathanso kuperewera magazi m'thupi.

Kugwiritsa ntchito metformin kumatha kubweretsa metformin yokhudzana ndi lactic acidosis. Mtundu uwu wa lactic acidosis nthawi zambiri umalumikizidwa ndi bongo wa metformin. Komabe, palinso chiopsezo cha lactic acidosis mwa anthu omwe amachepetsa chiwindi kapena impso. Zizindikiro za lactic acidosis zimaphatikizapo kunyoza, kuthamanga kwa magazi, komanso kupweteka m'mimba.

Funsani wothandizira zaumoyo kuti akuchenjezeni ndi zomwe mungachite pokhudzana ndi glipizide kapena metformin.

Mafunso omwe amafunsidwa pafupipafupi za glipizide vs. metformin

Kodi glipizide ndi chiyani?

Glipizide ndi mankhwala achibadwa omwe ali mgulu la mankhwala otchedwa sulfonylureas. Glipizide dzina lake ndi Glucotrol. Glipizide imagwira ntchito poonjezera kutulutsidwa kwa insulin m'mapapo kuti muchepetse shuga. Imapezeka ngati piritsi lokamwa lomwe limamasulidwa nthawi yomweyo.

Kodi metformin ndi chiyani?

Metformin imadziwikanso ndi mayina odziwika bwino monga Riomet ndi Glucophage. Ili m'gulu la mankhwala osokoneza bongo otchedwa biguanides. Metformin imagwira ntchito powonjezera kukhudzidwa kwa insulin, kuchepa kwa shuga m'chiwindi, ndikuchepetsa m'matumbo shuga. Metformin imapezeka ngati piritsi yamlomo yotulutsidwa mwachangu.

Kodi glipizide ndi metformin ndizofanana?

Glipizide ndi metformin sizofanana. Glipizide ndi sulfonylurea yomwe imathandizira mtundu wa 2 shuga mwa akulu ndipo metformin ndi biguanide yomwe imathandizira mtundu wa 2 shuga kwa akulu ndi ana omwe ali ndi zaka 10 kapena kupitirira. Glipizide ndi metformin amagwira ntchito m'njira zosiyanasiyana ndikukhala ndi mitundu yosiyanasiyana.

Kodi glipizide kapena metformin ndiyabwino?

Glipizide ndi metformin onse amagwira ntchito kuti achepetse magazi m'magazi mwa iwo omwe ali ndi matenda amtundu wa Type 2. Malinga ndi American Diabetes Foundation malangizo , metformin ndi mankhwala oyamba a mtundu wachiwiri wa shuga. Glipizide ndi metformin nthawi zina amatengedwa limodzi nthawi zina pamene kuchepa kwa shuga kumafunika. Ponseponse, mankhwala abwino kwambiri a shuga amatengera matenda anu komanso kuyankha kwa mankhwalawa.

Kodi ndingagwiritse ntchito glipizide kapena metformin ndili ndi pakati?

Poyerekeza ndi metformin, glipizide imatha kukhala ndi vuto lalikulu loyambitsa poizoni wa fetus. Malinga ndi kafukufuku wazinyama, metformin ikhoza kukhala yotetezeka kuti ingagwiritsidwe ntchito panthawi yapakati; koma palibe maphunziro omaliza mwa anthu omwe adachitidwa. Funsani wothandizira zaumoyo kuti adziwe njira yabwino kwambiri yothandizira mukakhala ndi pakati.

Kodi ndingagwiritse ntchito glipizide kapena metformin ndi mowa?

Sikulimbikitsidwa kumwa mowa wambiri mukamamwa glipizide kapena metformin . Kumwa mowa kumatha kuyambitsa shuga wosadalirika ndikuwonjezera chiopsezo cha hypoglycemia kapena hyperglycemia. Mowa amathanso kuwonjezera ngozi ya lactic acidosis mukakhala pa metformin.

Kodi nthawi yabwino kwambiri yamasana kuti mutenge glipizide ndi iti?

Nthawi yabwino kumwa glipizide musanadye kuti muchepetse vuto la hypoglycemia. Ngati imamwa kamodzi patsiku, glipizide imalangizidwa kuti imwetsedwe musanadye chakudya choyamba tsikulo.

Kodi glipizide ndiyabwino impso?

Matenda osasinthasintha amtundu wa shuga amatha kubweretsa zovuta monga kuwonongeka kwa impso. Komabe, glipizide sikudziwika kuti imawononga impso. Kuchotsa kwa glipizide kumatha kuchepetsedwa mwa anthu omwe ali ndi vuto la impso. Kudzikundikira kwa glipizide kumatha kubweretsa chiopsezo chowonjezeka cha shuga wotsika m'magazi.

Kodi mankhwala otetezedwa kwambiri pamtundu wachiwiri wa shuga ndi ati?

Metformin nthawi zambiri amapatsidwa mankhwala oyamba a mtundu wa 2 mwa anthu ambiri. Ndi chifukwa chakuti metformin ndi yotsika mtengo, yotetezeka, komanso yothandiza. Poyerekeza ndi ma antidiabetic agents, metformin imalumikizidwa ndi magulu otsika kapena ofanana a HbA1c . Kugwiritsiridwa ntchito kwa metformin kumalumikizidwanso ndi zochitika zochepa za hypoglycemia kuposa mankhwala ena monga sulfonylureas.