Pravastatin vs.Lipitor: Kusiyana, kufanana, ndi zomwe zili zabwino kwa inu
Mankhwala osokoneza bongo Vs. MnzanuKuwunika kwa mankhwala osokoneza bongo & kusiyana kwakukulu | Zinthu zothandizira | Mphamvu | Kuphunzira inshuwaransi ndikufanizira mtengo | Zotsatira zoyipa | Kuyanjana kwa mankhwala | Machenjezo | FAQ
Pravastatin ndi Lipitor (atorvastatin) ndi mankhwala akuchipatala omwe amagwiritsidwa ntchito pochiza cholesterol. Mafuta a cholesterol omwe ndi apamwamba kuposa achilengedwe amatha kuwonjezera ngozi ya matenda amtima, matenda amitsempha, matenda amtima, ndi sitiroko. Cholesterol amapangidwa makamaka m'chiwindi kudzera mu enzyme ya HMG-CoA reductase.
Pravastatin ndi atorvastatin ndi mankhwala omwe amadziwika kuti HMG-CoA reductase inhibitors. Amadziwikanso kuti statin drug, pravastatin ndi atorvastatin inhibit, kapena block, HMG-CoA reductase enzyme, yomwe imapangitsa kuchepa kwa cholesterol m'chiwindi. Kugwiritsa ntchito ma statins kumathandizanso kuchuluka kwa ma LDL (low-density lipoprotein) receptors m'chiwindi, omwe amathandizira kutsika kwa LDL, kapena mtundu woyipa wa cholesterol, m'magazi.
Onse pravastatin ndi atorvastatin amagwira ntchito mofananamo, koma ali ndi zosiyana zoti azidziwe.
Kodi pali kusiyana kotani pakati pa pravastatin ndi Lipitor?
Pravastatin ndi dzina lodziwika bwino la Pravachol. Mosiyana ndi mankhwala ena amtundu wa statin, pravastatin siyopangidwira kwambiri, kapena kusinthidwa, ndi michere ya CYP3A4 pachiwindi. M'malo mwake, pravastatin ndi wosweka m'mimba .
Mapiritsi achibadwa a Pravastatin amapezeka mwamphamvu za 10 mg, 20 mg, 40 mg, ndi 80 mg. Pravastatin nthawi zambiri amapatsidwa kuti azimwa kamodzi tsiku lililonse madzulo. Zawonetsedwa kuti pravastatin imagwira ntchito kwambiri ikamwedwa madzulo osati m'mawa.
Lipitor ndi mankhwala odziwika bwino ndipo amapezeka mumtundu wa generic wotchedwa atorvastatin. Mosiyana ndi pravastatin, atorvastatin imakonzedwa kwambiri ndi michere ya CYP3A4 m'chiwindi. Chifukwa chake, atorvastatin itha kuyanjana ndi mankhwala ambiri kuposa pravastatin.
Lipitor imapezeka m'mapiritsi amlomo okhala ndi mphamvu ya 10 mg, 20 mg, 40 mg, ndi 80 mg. Lipitor imatha kumwedwa m'mawa kapena madzulo, ndipo imamwedwa kamodzi tsiku lililonse.
| Kusiyana kwakukulu pakati pa pravastatin ndi Lipitor | ||
|---|---|---|
| Pravastatin | Lipitor | |
| Gulu la mankhwala osokoneza bongo | HMG-CoA reductase inhibitor | HMG-CoA reductase inhibitor |
| Chizindikiro cha Brand / generic | Ma brand ndi generic amapezeka | Ma brand ndi generic amapezeka |
| Kodi dzina lachibadwa ndi liti? Kodi dzina lake ndi ndani? | Dzina la dzina: Pravachol Dzina lachibadwa: Pravastatin | Dzina la dzina: Lipitor Dzina lachilengedwe: Atorvastatin |
| Kodi mankhwalawa amabwera mwa mawonekedwe ati? | Piritsi lapakamwa | Piritsi lapakamwa |
| Kodi mulingo woyenera ndi uti? | 10 mpaka 80 mg kamodzi tsiku lililonse | 10 mpaka 80 mg kamodzi tsiku lililonse |
| Kodi mankhwalawa amatenga nthawi yayitali bwanji? | Kutalika | Kutalika |
| Ndani amagwiritsa ntchito mankhwalawa? | Akuluakulu; ana ndi achinyamata azaka zapakati pa 8 mpaka 18 | Akuluakulu; ana ndi achinyamata azaka 10 mpaka 17 zaka |
Zomwe zimathandizidwa ndi pravastatin ndi Lipitor
Pravastatin ndi atorvastatin zitha kuthandiza kuchepetsa chiopsezo cha mtima komanso kukwapula mwa anthu omwe ali ndi matenda amtima. Mankhwala onsewa amathanso kuthandizira kuchepetsa ngozi yakufa matenda amtima . Zomwe zimayambitsa matenda amtima zimaphatikizapo kuthamanga kwa magazi, kusuta, komanso kuchuluka kwama cholesterol.
Onse pravastatin ndi atorvastatin ndi FDA yovomerezeka kuti ichepetse mafuta okwera kwambiri ndi ma LDL (amadziwikanso kuti hyperlipidemia kapena hypercholesterolemia). Mankhwala a Statin amathanso kuthandizira magulu okwera a triglycerides , omwe ndi mtundu wina wamafuta kapena lipids mthupi. Wina yemwe ali ndi milingo yokwera ya triglycerides ali ndi hypertriglyceridemia.
Pravastatin ndi Lipitor amathanso kuwonjezera milingo ya HDL m'magazi. HDL cholesterol ndi yomwe imadziwika kuti cholesterol yabwino m'magazi.
| Mkhalidwe | Pravastatin | Lipitor |
| Hyperlipidemia | Inde | Inde |
| Matenda osokoneza bongo | Inde | Inde |
| Hypertriglyceridemia | Inde | Inde |
Kodi pravastatin kapena Lipitor ndiyothandiza kwambiri?
Onse pravastatin ndi atorvastatin ndi mankhwala othandiza kuchiza cholesterol yamagazi. Mankhwala othandiza kwambiri amadalira momwe mulili, kukula kwa matenda anu, mankhwala ena omwe mukumwa, ndi zina.
Chimodzi kuphunzira poyerekeza anapeza kuti palibe kusiyana kwakukulu pakati pa pravastatin, simvastatin, ndi atorvastatin popewa zochitika zamtima. Mwanjira ina, mankhwalawa a statin anali othandiza mofananamo pochepetsa matenda amtima ndi matenda amtima.
KU kuwunika mwatsatanetsatane omwe adaphatikiza mayesero opitilira 90 poyerekeza mankhwala a statin monga fluvastatin, atorvastatin, pravastatin, simvastatin, ndi rosuvastatin. Kuwunikaku kunatsimikizira kuti atorvastatin, fluvastatin, ndi simvastatin anali ndi mwayi wambiri wothandiza kwambiri popewa zochitika zamtima.
Funsani wothandizira zaumoyo kuti akupatseni mankhwala abwino kwambiri. Pambuyo poyesa magazi ndikuwunika momwe mulili, wopezayo adzatha kudziwa ngati pravastatin kapena atorvastatin ndi mankhwala othandiza kwambiri kwa inu. Akhozanso kupereka mankhwala osiyana siyana monga Zocor (simvastatin) kapena Crestor (rosuvastatin).
Kuphunzira ndi kuyerekezera mtengo wa pravastatin vs. Lipitor
Pravastatin ndi mankhwala achibadwa omwe nthawi zambiri amapangidwa ndi Medicare ndi mapulani a inshuwaransi. Mtengo wapakati wamtengo wapatali wa pravastatin ndi pafupifupi $ 129.99 pamasiku 30. Khadi losungira la SingleCare litha kutsitsa mtengo wamankhwala a pravastatin kukhala ochepera $ 15.
Lipitor ndi mankhwala omwe amadziwika ndi dzina lake omwe amapezekanso pamtengo wotsika mtengo. Lipitor, atorvastatin, imakhala yolembedwa ndi ambiri a Medicare ndi mapulani a inshuwaransi. Lipitor yotchedwa Brand ingakhale ndi mapulani a inshuwaransi omwe ali ndi ndalama zambiri. Mtengo wamtengo wa Lipitor ndi pafupifupi $ 249.99. Makuponi a SingleCare atha kutsitsa mtengo mpaka $ 15 kuma pharmacies omwe akutenga nawo mbali.
| Pravastatin | Lipitor | |
| Nthawi zambiri amakhala ndi inshuwaransi? | Inde | Inde |
| Nthawi zambiri amakhala ndi Medicare Part D? | Inde | Inde |
| Kuchuluka | Mapiritsi 30 (40 mg) | Mapiritsi 30 (40 mg) |
| Wopanga Medicare wamba | $ 0 mpaka $ 20 | $ 0 mpaka $ 16 |
| Mtengo wosakwatiwa | $ 12 + | $ 15 + |
Zotsatira zoyipa za pravastatin vs. Lipitor
Zotsatira zoyipa kwambiri za pravastatin ndi minofu kapena mafupa, mseru, kusanza, kutsegula m'mimba, ndi mutu. Zotsatira zoyipa kwambiri za atorvastatin ndi minofu kapena mafupa, matenda otsekula m'mimba, komanso kupweteka kwaminyewa (arthralgia). Pravastatin ndi atorvastatin amathanso kuyambitsa zovuta zina monga kudzimbidwa, chizungulire, kutopa, zotupa, ndi matenda am'mikodzo.
Zovuta zoyipa zamankhwala osokoneza bongo Phatikizani matenda am'mimba (myopathy) ndikuwonongeka msanga kwa minofu ya minofu (rhabdomyolysis). Lumikizanani ndi othandizira azaumoyo nthawi yomweyo ngati mukumva kupweteka kosalekeza kapena kosamveka bwino, kufooka, kapena kukoma mtima.
Pravastatin ndi atorvastatin amathanso kuyambitsa michere yokwanira ya chiwindi. Magulu a enzyme ya chiwindi angafunike kufufuzidwa kale ndikuyang'aniridwa nthawi yonse ya chithandizo.
| Pravastatin | Lipitor | |||
| Zotsatira zoyipa | Zoyenera? | Pafupipafupi | Zoyenera? | Pafupipafupi |
| Kupweteka kwa minofu | Inde | 10% | Inde | 4% |
| Kunyansidwa / kusanza | Inde | 7% | Inde | 4% |
| Kutsekula m'mimba | Inde | 7% | Inde | 7% |
| Kudzimbidwa | Inde | 3% | Inde | 5% |
| Chizungulire | Inde | 4% | Inde | * |
| Mutu | Inde | 6% | Ayi | - |
| Kutopa | Inde | 3% | Inde | * |
| Kutupa | Inde | 5% | Inde | * |
| Matenda a Arthralgia | Inde | * | Inde | 7% |
| Matenda a mkodzo | Inde | 3% | Inde | 6% |
Pafupipafupi sizidalira zomwe zimayesedwa pamutu. Izi sizingakhale mndandanda wathunthu wazovuta zomwe zingachitike. Chonde onani dokotala wanu kapena wothandizira zaumoyo kuti mudziwe zambiri.
Gwero: DailyMed ( Pravastatin ), Tsiku Lililonse ( Lipitor )
* sananene
Kuyanjana kwa mankhwala a pravastatin vs. Lipitor
Pravastatin ndi atorvastatin amalumikizana ndi mankhwala ofanana. Komabe, popeza atorvastatin imapukusidwa makamaka ndi michere ya CYP3A4 m'chiwindi, imatha kulumikizana ndi mankhwala ena omwe amakhudza michere ya CYP3A4 m'chiwindi.
Kumwa mankhwala monga cyclosporine, clarithromycin, kapena ritonavir yokhala ndi pravastatin kapena atorvastatin kumatha kubweretsa kuchuluka kwama statin m'magazi, omwe angapangitse chiopsezo chazovuta.
Maantacids amatha kusokoneza kuyamwa kwa mankhwala a statin ndikuchepetsa mphamvu zawo. Maperekedwe a maantacid ndi ma statin ayenera kupatulidwa kwa maola osachepera awiri. Cholestyramine imathanso kuchepetsa mayamwidwe ndi mphamvu ya ma statins. Makonzedwe a cholestyramine ndi ma statins ayenera kupatulidwa ndi maola anayi.
Niacin ndi fibrate zitha kuwonjezera chiopsezo cha myopathy ndi rhabdomyolysis mukamamwa ndi pravastatin kapena atorvastatin.
Kugwiritsa ntchito atorvastatin kuyenera kupewedwa kapena kuyang'aniridwa mukamadya Madzi amphesa . Madzi amphesa amakhala CYP3A4 inhibitor yomwe imatha kubweretsa kuchuluka kwa atorvastatin m'magazi ndikuwonjezera mavuto.
| Mankhwala osokoneza bongo | Gulu la mankhwala osokoneza bongo | Pravastatin | Lipitor |
| Cyclosporine | Odwala matenda opatsirana pogonana | Inde | Inde |
| Clarithromycin Mankhwalawa | Maantibayotiki | Inde | Inde |
| Ketoconazole Chinthaka Voriconazole Posaconazole | Zosakaniza | Ayi | Inde |
| Ritonavir Simeprevir Ledipasvir Boceprevir Darunavir | Zosakaniza | Inde | Inde |
| Niacin | Othandizira ku Antilipemic | Inde | Inde |
| Fenofibrate Gemfibrozil | Amapanga | Inde | Inde |
| Digoxin | Ma glycosides amtima | Inde | Inde |
| Cholestyramine | Zotsatira za asidi a asidi | Inde | Inde |
| Zotayidwa hydroxide Mankhwala enaake a hydroxide | Maantibayotiki | Inde | Inde |
Funsani katswiri wa zamankhwala pazinthu zina zomwe zingagwiritsidwe ntchito ndi mankhwala.
Machenjezo a pravastatin ndi Lipitor
Pravastatin ndi atorvastatin ziyenera kupewedwa mwa iwo omwe ali ndi matenda opatsirana a chiwindi kapena milingo yayikulu ya enzyme ya chiwindi. Mankhwala amtundu wa Statin amatha kuwononga chiwindi china kwa munthu amene ali ndi matenda a chiwindi.
Pravastatin ndi atorvastatin siziyenera kugwiritsidwa ntchito kwa iwo omwe ali ndi mbiri yokhudzidwa ndi mankhwala a statin. Zizindikiro za hypersensitivity reaction zimaphatikizapo kuthamanga, kuyabwa, kutupa, komanso kupuma movutikira.
Mankhwala a Statin amakhala pachiwopsezo cha kuwonongeka kwambiri kwa minofu ndi kupweteka kwa minofu. Pakhoza kukhala chiopsezo chowonjezeka cha kupweteka kwa minofu kwa iwo omwe ali ndi zaka zopitilira 65 kapena omwe ali ndi vuto losalamulirika la hypothyroidism kapena mavuto a impso.
Pravastatin ndi atorvastatin sayenera kugwiritsidwa ntchito kwa omwe ali ndi pakati kapena akuyamwa.
Lankhulani ndi othandizira azaumoyo kuti akambirane machenjezo ena kapena zodzitetezera zokhudzana ndi pravastatin kapena atorvastatin.
Mafunso omwe amafunsidwa pafupipafupi za pravastatin vs. Lipitor
Kodi pravastatin ndi chiyani?
Pravastatin ndi mankhwala achibadwa omwe amagwiritsidwa ntchito kutsitsa cholesterol komanso kupewa zovuta zomwe zimadza chifukwa cha kuchuluka kwama cholesterol. Pravastatin dzina lake ndi Pravachol. Amaperekedwa kuti azitengedwa kamodzi tsiku lililonse madzulo. Pravastatin imapezeka ngati piritsi lokamwa.
Kodi Lipitor ndi chiyani?
Lipitor ndi mankhwala odziwika ndi dzina lopangidwa ndi Pfizer. Dzinalo la Lipitor ndi atorvastatin. Amagwiritsidwa ntchito kuthana ndi cholesterol yambiri ndikuchepetsa chiopsezo cha matenda a mtima ndi sitiroko. Lipitor imaperekedwa kuti izitengedwa kamodzi tsiku lililonse m'mawa kapena madzulo. Imapezeka ngati piritsi lokamwa.
Kodi pravastatin ndi Lipitor ndizofanana?
Onse pravastatin ndi atorvastatin ndi mankhwala omwe amagwiritsidwa ntchito pochepetsa cholesterol. Komabe, sizofanana. Atorvastatin imagwiritsidwa ntchito makamaka ndi mavitamini a CYP P450 m'chiwindi pomwe pravastatin idagwa m'mimba. Pravastatin nthawi zambiri amatengedwa usiku pomwe Lipitor amatengedwa m'mawa kapena madzulo.
Kodi pravastatin kapena Lipitor ndibwino?
Onse pravastatin ndi Lipitor ndi mitundu yothandiza ya mankhwala a statin. Mankhwala onsewa amatha kuthana ndi vuto la cholesterol, monga atherosclerosis, matenda amtima, ndi sitiroko. Kafukufuku wina wochokera ku Magazini azamtima apeza kuti atorvastatin, chinthu chogwira ntchito ku Lipitor, ndichothandiza kwambiri kuposa mankhwala ena a statin oletsa zochitika zamtima ndi mtima. Wopereka chithandizo chamankhwala amatha kukupatsani upangiri wachipatala pamankhwala abwino kwambiri a statin kwa inu.
Kodi ndingagwiritse ntchito pravastatin kapena Lipitor ndili ndi pakati?
Pravastatin ndi atorvastatin sakulimbikitsidwa kuti atengedwe ali ndi pakati. Mankhwala onsewa ali pachiwopsezo chachikulu chobweretsa zolakwika kubadwa. Funsani wothandizira zaumoyo kuti akuthandizeni malangizo abwino a cholesterol chambiri mukakhala ndi pakati.
Kodi ndingagwiritse ntchito pravastatin kapena Lipitor ndi mowa?
Palibe ngozi yayikulu yathanzi yomwe imakhalapo chifukwa chomwa mowa kwambiri komanso ma statins. Mankhwala osokoneza bongo komanso kumwa kwambiri mowa zitha kuwononga chiwindi . Lankhulani ndi omwe amakuthandizani kuti muwone ngati zili bwino kuti muzimwa mowa mukamamwa mankhwala osokoneza bongo.
