Maantibayotiki 8 omwe amachititsa C. Diff

Maphunziro a Zaumoyo

Kukhazikitsidwa kwa maantibayotiki ochiritsa matenda mosakayikira kunasinthiratu zamankhwala mzaka zapitazi. Koma zina mwa mankhwalawa, monga momwe amatchulidwira kale, amathanso kusiya thupi kukhala lotetezeka ku matenda opatsirana otchedwa C. Difficile.

Kodi C. Diff ndi chiyani?

Clostridioides amakhala , poyamba ankadziwika kuti Clostridium difficile , kapena C.Diff, ndi mabakiteriya opatsirana zomwe zingayambitse kutsegula m'mimba kwambiri. Zizindikiro zina zodziwika bwino za C zimaphatikizapo kutentha thupi, nseru, kusowa chilakolako, komanso kupweteka m'mimba.

Zikuyesa kuti zayambitsa pafupifupi 500,000 matenda ku United States ndi Anthu 15,000 amwalira chaka chilichonse, malinga ndi Malo Othandizira Kuletsa ndi Kupewa Matenda . Pakadali pano amadziwika ndi CDC ngati Zowopsa Mwamsanga - malo oopseza kwambiri a Centers-kuumoyo wa anthu kuchokera ku tizilombo toyambitsa matenda ku US (CDC ikukonzekera kumasula lipoti losinthidwa zokhudzana ndi izi mu kugwa kwa 2019.)

Ndi maantibayotiki ati omwe amachititsa C. Diff?

Ndiye kodi kugwiritsa ntchito maantibayotiki kumapangitsa bwanji kuti munthu atenge matenda owopsa ngati C. Diff? Mukamamwa mankhwala opha tizilombo, amagwira ntchito kupha matenda a bakiteriya mthupi lanu. Pochita izi, mankhwalawa amathanso kuwononga mabakiteriya athanzi omwe amasunga owukira ngati C. Diff. Ndikofunika kuzindikira, si maantibayotiki onse omwe amachititsa C.Diff, ndipo si onse omwe ali pachiwopsezo chofanana. Ngakhale kuti pafupifupi maantibayotiki onse amatha kuyambitsa vutoli, vuto lalikulu kwambiri, pankhaniyi, nthawi zambiri limakhala mankhwala opha tizilombo ambiri. Omwe ali pachiwopsezo chachikulu ndi odwala azaka 65 kapena kupitilira apo omwe adakhala m'malo azaumoyo, monga kuchipatala kapena nyumba yosamalirako okalamba.

Maantibayotiki ophatikizika amtunduwu amakhala ndi zochita motsutsana ndi mabakiteriya [akulu] ambiri omwe amakhala m'matumbo, akufotokoza Dr. Hana Axelrod , pulofesa wothandizira zamankhwala ku Division of Infectious Disease ku George Washington School of Medicine ndi Health Science . Ndikofunika kwambiri kukhala ndi thanzi labwino komanso losiyanasiyana la mabakiteriyawa. Anthu akapatsidwa maantibayotiki osiyanasiyana, mabakiteriya am'matumbo awo amachepa, potero amalola kuti tizilombo toyambitsa matenda, monga C. Diff, tipeze mabakiteriya ankhanza omwe amatulutsa poizoni omwe amawononga matumbo ndikupangitsa matenda oopsa kwambiri.

Erika Prouty, Pharm.D., Yemwe anali pulofesa wothandizira ku Western New England University College of Pharmacy ku Springfield, Massachusetts, ikuwonjezeranso izi: Maantibayotiki ambiri atha kukhala owopsa kwa odwala chifukwa samangoyang'ana mabakiteriya oyipa omwe tikufuna kuwathetsanso, komanso amapha mabakiteriya ambiri abwino omwe ali m'thupi mwathu .

Onse awiri Dr. Akselrod ndi Dr. Prouty amadziwika kuti clindamycin ndi fluoroquinolones ndi ena mwa olakwira kwambiri. Mndandanda wa maantibayotiki omwe zingayambitse C.Diff zikuphatikizapo:

• cephalosporins
• chiwoo ( Cleocin )
• ciprofloxacin ( Kupro )
• kutchfuneralhome ( Levaquin )
• moyankwo ( Avalox , Vigamox )
• amoxicillin (Amoxil)

Ndizomvetsa chisoni, akutero Dr. Akselrod, chifukwa maantibayotiki amenewo amagwiritsidwa ntchito kwambiri pazonse kuyambira chibayo mpaka matenda am'mikodzo. Vuto linanso ndilofunikira kwa maantibayotiki ena a IV omwe amagwiritsidwa ntchito nthawi zonse ndi asing'anga muzipinda zadzidzidzi zachipatala, zomwe zimakhalanso pansi pa ambulera yotakata. Mankhwalawa ndi awa:

• piperacillin / tazobactam (Zosyn)
• meropenem (Ndimatenga)

Maantibayotiki a IV ndi achizolowezi m'malo mwa ER chifukwa amagwiritsidwa ntchito ngati mankhwala oyamba pomwe odwala adwala ndipo sakudziwa chomwe chikuyambitsa matendawa, akufotokoza Dr. Akselrod. Koma monga katswiri wazachipatala atenga mbali imeneyi, amadziwa bwino madotolo oyenera omwe madotolo akuyenera kutsatira potengera onse omwe akuchiza matendawa, osayambitsa matenda ena. Popita nthawi tazindikira zoopsa motsutsana ndi maubwino amtunduwu wamankhwala wamba, akutero. Kungakhale kuyimba kovuta kuti ayambe kapena ayi kuyambitsa maantibayotiki a IV. Chomwe chimatithandiza kupanga chisankho choyenera ndi njira yanzeru ndikuyesera kukhala ndi chifukwa chenicheni choperekera maantibayotiki.

Ndi maantibayotiki ati omwe sangayambitse C. Diff?

Ngati muli pachiwopsezo chachikulu cha C.Diff, ndibwino kuti mulankhule ndi dokotala wanu zakusankha chithandizo chochepa. Maantibayotiki omwe ali sizingayambitse C.Diff monga:

• azithromycin ( Zithromax , Z-Pak )
• chithuchithu (Biaxin)
• kutuloji ( Oracea , Vibramycin )
• erythromycin ( Kutsekedwa )
• fidaxomicin ( Zovuta )
• minocycline (Zojambula, Solod )
• metronidazole (Flagyl)

Ndi maantibayotiki ati omwe amachiza C. Diff?

Ngakhale mankhwalawa ali pamwamba pa mndandanda wa zoyambitsa za C. Diff, pali mitundu yochepa chabe ya maantibayotiki a Diff omwe amatha kuchiza matendawa. Vancomycin ndi mankhwala omwe amagwiritsidwa ntchito kwambiri kwa C.Diff, akutero Dr. Prouty, ponena kufunika kwa pakamwa, mosiyana ndi IV, chithandizo: IV siyilowerera kwenikweni m'matumbo, motero ndi yopanda ntchito. Ndipo popeza matenda onse amayamba chifukwa cha tizilombo tating'onoting'ono tosiyanasiyana (bakiteriya yomwe imayambitsa matenda), si maantibayotiki onse omwe amalimbana ndi tizilombo toyambitsa matenda tiwapha, akutero. Chifukwa chake, mankhwala enieni ayenera kugwiritsidwa ntchito pa C. Diff chithandizo.

Zanenedwa kuti mitengo ya C.iff yagwa mzaka zaposachedwa pang'ono pang'ono chifukwa cha mapulogalamu oyang'anira maantibayotiki muzipatala, zomwe zimafuna kuchepetsa kupatsidwa mankhwala osafunikira. Koma zikafika pokhudzana ndi odwala kuchita chidwi ndi C. Diff kupewa, Dr. Akselrod akuti chinthu choyamba chomwe angachite ndikukambirana moona mtima ndi omwe amawapatsa chithandizo chamankhwala ngati akufuna mankhwalawo, komanso kuti achepetse nthawi yomwe agwiritsa ntchito pa iyo.