Waukulu >> Nkhani >> Kumanani ndi Ubrelvy, mankhwala atsopano ovomerezeka a FDA omwe amachiritsa migraine

Kumanani ndi Ubrelvy, mankhwala atsopano ovomerezeka a FDA omwe amachiritsa migraine

Nkhani

Pafupifupi 1 mwa mabanja anayi aku US, wina amadwala mutu waching'alang'ala, malinga ndi Migraine Research Foundation . Ndipo ambiri mwa omwe akhudzidwa sanapeze mankhwala omwe amagwira ntchito. Tsopano, pali chatsopano chithandizo cha migraine mwina posachedwa. A FDA adavomereza Ubrelvy (ubrogepant) posachedwa, mankhwala omwe amachita mwachangu kuti athandize kufupikitsa kutalika kwa mutu waching'alang'ala.

Kodi mutu waching'alang'ala ndi chiyani?

Migraine sikuti imangodwala mutu. M'malo mwake, mutu waching'alang'ala imawerengedwa ngati matenda achisanu ndi chimodzi opundula kwambiri padziko lapansi. Kuwonjezera pa kupweteka kwa mutu, kusokonezeka m'maso, kunyoza, kusanza, chizungulire, kumva kwambiri mawu, kuwunika, kukhudza ndi kununkhiza, komanso kulira kapena kuzizira kumapeto kapena nkhope nthawi zambiri kumatsagana ndi migraines.

ZOKHUDZA : Nthawi yoti mukalankhule ndi dokotala za mankhwala okhudza migraines

Kodi migraines ndi yofala motani?

12% ya anthu kuphatikiza 10% ya ana - amamva mutu waching'alang'ala. Amakhudza azimayi aku America aku 18% komanso amuna 6%. Ponseponse, amenewo ndi anthu opitilira 4 miliyoni omwe ali ndi mutu waching'alang'ala wosachiritsika tsiku lililonse ndipo amakumana ndi masiku opitilira 15 a migraine pamwezi.

Mankhwala a Migraine

Pali mankhwala ambiri omwe mungalandire omwe angakuthandizeni kupewa mutu waching'alang'ala, ndipo muzichiza matendawa mukangoyamba kumene. Kuphatikiza apo, madotolo nthawi zina amalimbikitsa kusintha kwamachitidwe (monga kuchepetsa kupsinjika kapena kuzimitsa magetsi), amalimbikitsa odwala kuti azigula pa-counter kapena mphamvu zamankhwala NSAIDs (monga ibuprofen ) kuthana ndi ululu, kupereka mankhwala opatsirana pogonana, mankhwala opatsirana pogonana, mankhwala a antiepileptic, beta blockers, komanso kulangiza odwala kulandira Botox jakisoni kuchepetsa pafupipafupi ndi zizindikiro za mutu wawo waching`alang`ala.

ZOKHUDZA : Kodi muyenera kutenga Topamax pa migraines yanu?

Ubrelvy (ubrogepant) ndi chiyani?

Ubrelvy (ubrogepant) ndi mankhwala aposachedwa kwambiri a mutu waching'alang'ala (wopanda kapena wopanda aura). Ndi chithandizo chatsopano, kutanthauza, ndi nthawi yoyamba kuti kalasi yamankhwalayi ivomerezedwe kuti ichiritse mutu waching'alang'ala. Izi zikhoza kukhala nkhani zosintha moyo kwa odwala omwe sanapezepo mpumulo ku mankhwala omwe alipo kale.

Mankhwala ovomerezeka ndi FDA amatsimikiziridwa mwachipatala kuti amachepetsa kutalika kwa magawo a migraine, komanso amachepetsa kupweteka ndi zizindikilo zomwe zimakhudzana nawo. Zimagwira ntchito poletsa zotsatira za calcitonin peptide yokhudzana ndi majini (CGRP) receptor. CGRP yatsimikiziridwa kuti ndi gawo limodzi lamkati lomwe limayambitsa komanso kulimbikitsa migraines. Ndipo ngakhale pali mankhwala ena -Majakisoni odziwika ndi dzina la Aimovig , Mphamvu , ndi Chisangalalo -Omwe amaletsa mutu waching'alang'ala potseka CGRP, Ubrelvy imayima pambali chifukwa ndi mankhwala am'kamwa omwe amathandizira kuchiritsa mutu waching'alang'ala pomwe zikuchitika kale. Zimabwera ndi zosankha ziwiri (50 ndi 100 mg mapiritsi) kuti athe kusinthasintha zosowa za odwala ndikuwonjezera mphamvu kwa anthu ambiri.

Ubrelvy adapambana mayesero azachipatala, zomwe zidapangitsa kuti avomerezedwe komaliza ndi oyang'anira. Malinga ndi a FDA, mphamvu ya mankhwalawa idawonetsedwa m'mayesero awiri olamulidwa mosagwirizana, omwe ali ndi khungu. Munthawi yamaphunziro, odwala 1,439 achikulire omwe ali ndi mbiri ya mutu waching'alang'ala (wokhala ndi wopanda aura) adalandira milingo yovomerezeka ya Ubrelvy kuti athe kuchiza mutu waching'alang'ala.

M'maphunziro onsewa, pafupifupi 19% ya odwala akuti sanamve kuwawa patatha maola awiri atalandira chithandizo chamankhwala (kutanthauziridwa ngati kuchepa kwa kupweteka kwa mutu kuchokera kupweteka pang'ono kapena kupweteka kopanda ululu) ndipo 38.6% akuti akumva kupumula kwathunthu ku chizindikiro chawo china chowopsa cha migraine (nseru , kutengeka pang'ono, kapena kuzindikira kwamphamvu) maola awiri mutalandira chithandizo. Ziwerengerozi ndizokwera kwambiri pakati pa odwala omwe amalandira Ubrelvy (pamlingo uliwonse) poyerekeza ndi omwe adalandira malowa.

Zotsatira zoyipa kwambiri za Ubrelvy ndi nseru komanso kusowa mtendere (kutopa).

Monga gepant woyamba wamlomo, Ubrelvy imapereka njira yatsopano komanso yosiyaniranayi ndi anthu omwe ali ndi zowawa zofooketsa komanso zizindikilo zina za migraine, a David Nicholson, wachiwiri kwa purezidenti wamkulu komanso wamkulu wa R&D ofisala ya kampani ya Ubrelvy, Allergan, adatero cholengeza munkhani . Kuwongolera pakamwa kwake ndi mphamvu ziwiri zamankhwala kumathandizira kuti kusinthasintha kwa chithandizo ndi kupumula pakayambika migraine. Pamene tikupitiliza kuyendetsa zatsopano pamankhwala a migraine, ndife onyadira kupereka kwa odwala njira ina, ndipo tili ndi chidaliro kuti ipanga kusiyana kwa omwe akusowa thandizo. Ku Allergan, timakhulupirira kuti odwala migraine amayenera kulandira mankhwala atsopano onse a matendawa.