Trintellix vs.Viibryd: Kusiyana, kufanana, ndi zomwe zili zabwino kwa inu
Mankhwala osokoneza bongo Vs. MnzanuKuwunika kwa mankhwala osokoneza bongo & kusiyana kwakukulu | Zinthu zothandizira | Mphamvu | Kuphunzira inshuwaransi ndi kufananiza mtengo | Zotsatira zoyipa | Kuyanjana kwa mankhwala | Machenjezo | FAQ
Oposa 17 miliyoni aku America ali nawo kukhumudwa (kusokonezeka kwakukulu-MDD). Zochitika zaposachedwa, monga mliri wa COVID-19, zakhala zowononga kwambiri, zomwe zakhudza thanzi la anthu ambiri.
Trintellix (vortioxetine) ndi Viibryd (vilazodone) ndi mankhwala opatsirana pogonana. Mankhwala onsewa amavomerezedwa ndi United States Food and Drug Administration (FDA) ndipo amapezeka mwa mankhwala. Takeda Pharmaceuticals, Inc. imapanga Trintellix; Allergan, Inc. amapanga Viibryd. Trintellix kapena Viibryd itha kugwiritsidwa ntchito limodzi ndi psychotherapy ndi psychologist kapena psychiatrist.
Trintellix ndi Viibryd ndi amodzi mwa mankhwala omwe amatchedwa serotonin reuptake inhibitors (SSRIs). Zomwe zimachepetsa kupsinjika zimachitika ma SSRIs akachulukitsa ma serotonin muubongo, ndikuthandizira kukonza zizindikilo za kukhumudwa. Mankhwala onsewa ali ndi zochitika zina pama serotonin receptors, koma kufunikira kwa ntchito yowonjezerayi sikudziwika kapena kumveka. Pachifukwa ichi, nthawi zina amatchedwa antidepressants kapena serotonin modulators.
Kodi pali kusiyana kotani pakati pa Trintellix ndi Viibryd?
Trintellix (vortioxetine) ndi mankhwala a SSRI. Amadziwikanso kuti serotonin modulator kapena atypical antidepressant. Trintellix imapezeka mu dzina lokha, piritsi. Trintellix itha kugwiritsidwa ntchito kwa akulu okha-sichinaphunzire kwa ana. (Chidziwitso: Trintellix poyamba amatchedwa Brintellix, koma dzina linasinthidwa kupewa chisokonezo ndi Brilinta, mankhwala oletsa antiplatelet.)
Viibryd (vilazodone) ndi mankhwala a SSRI omwe amapezeka m'maina apakompyuta. Monga Trintellix, Viibryd imaphatikizidwanso ngati serotonin modulator kapena atypical antidepressant. Viibryd sivomerezeka kuti igwiritsidwe ntchito kwa ana. Zimangowonetsedwa kuti zigwiritsidwe ntchito kwa akulu.
| Kusiyana kwakukulu pakati pa Trintellix ndi Viibryd | ||
|---|---|---|
| Zamgululi | Viibryd | |
| Gulu la mankhwala osokoneza bongo | SSRI (serotonin reuptake inhibitor) / atypical antidepressant / serotonin modulator | SSRI (serotonin reuptake inhibitor) / atypical antidepressant / serotonin modulator |
| Chizindikiro cha Brand / generic | Mtundu | Mtundu |
| Kodi dzina lachibadwa ndi liti? | Vortioxetine | Vilazodone |
| Kodi mankhwalawa amabwera mwa mawonekedwe ati? | Piritsi | Piritsi |
| Kodi mulingo woyenera ndi uti? | Yambani pa 10 mg patsiku, kenako onjezerani 20 mg patsiku ngati mukulekerera. | Yambani pa 10 mg patsiku masiku asanu ndi awiri, kenako onjezani 20 mg patsiku ngati kuli kofunikira. Tengani ndi chakudya. |
| Kodi mankhwalawa amatenga nthawi yayitali bwanji? | Zimasintha | Zimasintha |
| Ndani amagwiritsa ntchito mankhwalawa? | Akuluakulu | Akuluakulu |
Zomwe amathandizidwa ndi Trintellix ndi Viibryd
Trintellix ndi Viibryd onse akuwonetsedwa kuti amachiza MDD, kapena vuto lalikulu lokhumudwitsa (kukhumudwa kwakukulu), mwa akulu. Palibe mankhwala omwe amavomerezedwa kuti agwiritsidwe ntchito kwa odwala.
Trintellix kapena Viibryd nthawi zina amapatsidwa osalemba Matenda amisala wamba kapena zina.
| Mkhalidwe | Zamgululi | Viibryd |
| Matenda akulu achikulire (MDD) mwa akuluakulu | Inde | Inde |
| Matenda amisala wamba | Kutumiza | Kutumiza |
Kodi Trintellix kapena Viibryd ndiyothandiza kwambiri?
Phunziro limodzi adayang'ana mankhwala 21 opondereza, kuphatikizapo Trintellix ndi Viibryd. Kafukufukuyu adapeza kuti Trintellix ndi imodzi mwamankhwala othandiza kwambiri komanso olekerera. Pali zochepa kwambiri poyerekeza mankhwala awiriwo mutu ndi mutu.
Mankhwala othandiza kwambiri kwa inu angadziwike ndi omwe amakuthandizani paumoyo wanu, omwe angaganizire zaumoyo wanu komanso mbiri yanu, ndi mankhwala aliwonse omwe mungamwe omwe angagwirizane ndi Trintellix kapena Viibryd.
Kuphatikiza ndi kuyerekezera mtengo kwa Trintellix vs.Viibryd
Trintellix imakhala ndi inshuwaransi yambiri komanso mapulani a mankhwala a Medicare. Mtengo wakuthumba uli pafupifupi $ 500 pamapiritsi 30, 20 mg. Khadi laulere la SingleCare limatha kutsitsa mtengo mpaka pafupifupi $ 345.
Mapulogalamu ambiri a inshuwaransi ndi Medicare amakhudza Viibryd. Mtengo wakuthumba wamapiritsi a 30, 20 mg utha kukhala pafupifupi $ 400. Ndi khadi laulere la SingleCare mutha kulipira ndalama zochepa ngati $ 278 kuma pharmacies omwe akutenga nawo mbali.
Mapulani a inshuwaransi amasiyana. Lumikizanani ndi kampani yanu ya inshuwaransi kuti mumve zambiri zokhudza inshuwaransi yanu.
| Zamgululi | Viibryd | |
| Nthawi zambiri amakhala ndi inshuwaransi? | Inde | Inde |
| Nthawi zambiri amakhala ndi Medicare Part D? | Inde | Inde |
| Mlingo woyenera | 30, 20 mg mapiritsi | 30, 20 mg mapiritsi |
| Wopanga Medicare wamba | $ 3- $ 14 | $ 1- $ 10 |
| Mtengo wosakwatiwa | $ 345 + | $ 278 + |
Zotsatira zoyipa za Trintellix vs.Viibryd
Zotsatira zoyipa kwambiri za Trintellix ndi mseru. Mseruwu umakhala wofatsa pang'ono ndipo umatha pafupifupi milungu iwiri. Zochitika zina zodziwika bwino za Trintellix zimaphatikizapo zovuta zakugonana, nseru, kudzimbidwa, kusanza, kutsekula m'mimba, mkamwa mouma, komanso chizungulire.
Zotsatira zoyipa kwambiri za Viibryd ndi kutsegula m'mimba, nseru, kusanza, ndi kugona tulo.
Ndi mankhwala aliwonse atsopano kapena odzazidwanso a Trintellix kapena Viibryd, mudzalandira chitsogozo cha mankhwala chomwe chimakambirana za zovuta, machenjezo, ndi zina zofunika.
Ili si mndandanda wathunthu wazotsatira. Zotsatira zina zoyipa zimatha kuchitika. Funsani omwe amakuthandizani kuti mupeze mndandanda wazomwe zingachitike.
| Zamgululi | Viibryd | |||
| Zotsatira zoyipa | Zoyenera? | Pafupipafupi | Zoyenera? | Pafupipafupi |
| Mutu | Inde | % sananene | Inde | khumi ndi zisanu% |
| Nseru | Inde | 21% -32% | Inde | 22% |
| Kusanza | Inde | 5% -6% | Inde | 4% |
| Kusokonezeka / kutha kwa kugonana | Inde | 16% -34% | Inde | 1% -3% |
| Kutsekula m'mimba | Inde | 7% -10% | Inde | 26% |
| Kudzimbidwa | Inde | 3% -6% | Ayi | - |
| Pakamwa pouma | Inde | 6% -8% | Inde | 8% |
| Kusinza | Ayi | - | Inde | 4% |
| Chizungulire | Inde | 6% -9% | Inde | 6% |
| Kusowa tulo | Ayi | - | Inde | 7% |
| Kulemera | Inde | % sananene koma sanena chilichonse chokhudza thupi | Inde | 1% -2% |
* zoyipa zimadalira mlingo
Gwero: DailyMed ( Zamgululi ), Tsiku Lililonse ( Viibryd )
Kuyanjana kwa mankhwala a Trintellix vs.Viibryd
Chifukwa mankhwala onsewa ali mgulu limodzi, amakhala ndi machitidwe ofanana azamankhwala.
MAOI (monoamine oxidase inhibitors) amalumikizana ndi Trintellix ndi Viibryd. Kugwiritsa ntchito kwawo kuyenera kulekanitsidwa ndi masiku 14-21, kutengera dongosolo la chithandizo. Kuphatikiza MAOI ndi Trintellix kapena Viibryd kumawonjezera ngozi matenda a serotonin , mwangozi zoopsa zachipatala chifukwa cha serotonin yochulukirapo.
Ma Triptan monga Imitrex (sumatriptan), ndi mankhwala ena opewetsa kupsinjika, monga Prozac kapena Cymbalta, sayenera kuphatikizidwa ndi Trintellix kapena Viibryd chifukwa chowopsa cha matenda a serotonin.
Dextromethorphan ya chifuwa (yomwe imapezeka ku Robitussin-DM komanso mitundu ina yambiri ya chifuwa ndi kuzizira) iyenera kupewedwa chifukwa imatha kupatsanso matenda a serotonin akaphatikizidwa ndi Trintellix kapena Viibryd.
Mankhwala ena omwe amatha kulumikizana ndi Trintellix kapena Viibryd amaphatikizapo mankhwala osagwiritsa ntchito zotupa (NSAIDs) monga aspirin kapena ibuprofen, ndi anticoagulants (oponda magazi) ngati warfarin. Pewani mowa mukamamwa Trintellix kapena Viibryd.
Ili si mndandanda wathunthu wazomwe zimachitika ndi mankhwala. Funsani wothandizira zaumoyo wanu kuti mupeze mndandanda wathunthu wamagwiridwe antchito.
| Mankhwala osokoneza bongo | Gulu la mankhwala osokoneza bongo | Zamgululi | Viibryd |
| Phenelzine Rasagiline Selegiline Zamgululi | MAOIs | Inde | Inde |
| Mowa | Mowa | Inde | Inde |
| Rizatriptan Sumatriptan Zolmitriptan | Zolemba | Inde | Inde |
| St. John's Wort | Zowonjezera | Inde | Inde |
| Warfarin | Wotsutsa | Inde | Inde |
| Codeine Hydrocodone Morphine Oxycodone Zamgululi | Opioids | Inde | Inde |
| Dextromethorphan (m'mafupa ambiri ndi mankhwala ozizira) | Chifuwa suppressant | Inde | Inde |
| Asipilini Zamgululi Meloxicam Nabumetone Naproxen | NSAIDs | Inde | Inde |
| Chotsani Duloxetine Katemera | SNRI antidepressants | Inde | Inde |
| Amitriptyline Desipramine Imipramine Mzere wa Nortriptyline | Tricyclic antidepressants | Inde | Inde |
| Alprazolam Clonazepam Diazepam | Benzodiazepines | Ayi | Inde |
| Digoxin | Mtima glycoside | Ayi | Inde |
| Carbamazepine Phenytoin Rifampin | Makina olimbikitsa amtundu wa enzyme cytochrome P 450 3A4 | Inde | Inde |
| Clarithromycin Chinthaka Ketoconazole | Amphamvu oletsa ma enzyme cytochrome P 450 3A4 | Ayi | Inde |
Machenjezo a Trintellix ndi Viibryd
Ma SSRIs onse, kuphatikiza Trintellix ndi Viibryd, ali ndi chenjezo lakuda (chenjezo lamphamvu kwambiri lofunikira ndi a FDA) lodzipha. Ana, achinyamata, komanso achikulire (mpaka zaka 24) omwe amamwa mankhwala opatsirana amakhala ndi chiopsezo chowonjezeka chodzipha ndi malingaliro. Odwala onse pa mankhwala opatsirana pogonana ziyenera kuyang'aniridwa mosamala.
Machenjezo ena ndi awa:
- Matenda a Serotonin ndiwopseza moyo chifukwa cha serotonin yambiri. Odwala omwe amatenga Trintellix kapena Viibryd ayenera kuyang'aniridwa ngati ali ndi zizindikiro za matenda a serotonin, kuphatikizapo kuyerekezera zinthu m'maganizo, kugwidwa, kusintha kwa magazi, komanso kusokonezeka. Odwala ayenera kupita kuchipatala mwadzidzidzi ngati zizindikiro zikuchitika. Mankhwala ena omwe amachulukitsa kuchuluka kwa serotonin (triptans, tricyclic antidepressants, fentanyl, lithium, tramadol, tryptophan, buspirone, dextromethorphan, amphetamines, St. John's Wort, ndi MAOIs) zimawonjezera chiopsezo cha matenda a serotonin akaphatikizidwa ndi Trintellix kapena Viibryd.
- SSRIs imatha kuwonjezera ngozi yakutuluka magazi, ndipo chiwopsezo chimakula ndikamagwiritsa ntchito ma aspirin, ma NSAID, kapena warfarin.
- Kukhazikitsa kwa mania kapena hypomania kumatha kuchitika. Odwala omwe ali ndi vuto losinthasintha zochitika, wopanikizika amatha kutulutsa gawo losakanikirana.
- Pewani ma SSRIs kapena muzigwiritsa ntchito mosamala kwa odwala omwe ali ndi ma angles osatetezedwa (anatseka-glaucoma). Funsani wothandizira zaumoyo wanu ngati muli pachiwopsezo.
- Hyponatremia (otsika sodium) chifukwa cha matenda osayenera a antidiuretic hormone secretion (SIADH) atha kuchitika. Odwala amatha kupwetekedwa mutu, kuvutika kuganizira, kukumbukira kukumbukira, kusokonezeka, kufooka, komanso kusakhazikika, mwina komwe kumatha kugwa. Odwala ayenera kupeza chithandizo chadzidzidzi ngati zizindikiro zikuchitika ndikusiya SSRI.
- Mukasiya Trintellix kapena Viibryd, mankhwalawa amayenera kupendedwa pang'onopang'ono kuti apewe zizindikiritso monga kusuta, kukwiya, kusokonezeka, kupweteka mutu, komanso kugwidwa. Osasiya mwadzidzidzi kumwa Trintellix kapena Viibryd. Wothandizira zaumoyo wanu akhoza kukulangizani za njira yabwino yoletsera Trintellix kapena Viibryd.
- Osayendetsa (kapena kugwiritsa ntchito makina) mpaka mutadziwa momwe Trintellix kapena Viibryd zimakukhudzirani.
- Ngati muli ndi mbiri yakugwa, lankhulani ndi omwe amakuthandizani kuti mugwiritse ntchito Trintellix kapena Viibryd.
- Nthawi zina, thupi lawo siligwirizana. Ngati mukumva zizindikiro zosafunikira kapena kupuma movutikira, siyani kumwa Trintellix kapena Viibryd, ndipo nthawi yomweyo pitani kuchipatala.
Trintellix kapena Viibryd ayenera kugwiritsidwa ntchito pathupi ngati phindu kwa mayi ndiloposa chiopsezo kwa mwana. Kuyimitsa mankhwalawa kumatha kuyambitsanso kukhumudwa kapena kuda nkhawa. Chifukwa chake, odwala amayenera kuwunikidwa pamlanduwu. Wothandizira zaumoyo wanu amatha kuyeza zoopsa poyerekeza ndi phindu logwiritsa ntchito SSRI panthawi yapakati. Ma Neonates omwe amapezeka ku SSRI m'gawo lachitatu lachitatu akhala ndi zovuta zomwe zimafunikira kuchipatala kwakanthawi, chithandizo cha kupuma, komanso kudyetsa chubu. Ngati muli pa Trintellix kapena Viibryd ndipo mukudziwa kuti muli ndi pakati, funsani omwe akukuthandizani nthawi yomweyo.
Mafunso omwe amafunsidwa pafupipafupi za Trintellix vs. Viibryd
Kodi Trintellix ndi chiyani?
Trintellix ndi SSRI, kapena serotonin reuptake inhibitor yosankha. Chifukwa cha ntchito zina zama serotonin receptors, amadziwikanso kuti ndi antidepressant. Ikupezeka mu dzina la dzina ndipo imagwiritsidwa ntchito kuthana ndi kukhumudwa kwa akulu.
Kodi Viibryd ndi chiyani?
Viibryd ndi dzina lotchedwa SSRI. Monga Trintellix, amadziwikanso kuti ndi antidepressant. Viibryd imagwiritsidwa ntchito kuthana ndi kukhumudwa kwa akulu.
Kodi Trintellix ndi Viibryd ali ofanana? / Ndi mankhwala otani opatsirana omwe amafanana ndi Viibryd?
Trintellix ndi Viibryd onse amachita ngati mankhwala osokoneza bongo a SSRI. Mankhwala ena a SSRI omwe mwina mwamvapo ndi awa: Celexa (citalopram), Lexapro (escitalopram), Luvox (fluvoxamine), Paxil (paroxetine), Prozac (fluoxetine), ndi Zoloft (sertraline).
Komabe, ngakhale Trintellix ndi Viibryd amachita ngati SSRIs, imagwiranso ntchito m'njira zina pama serotonin receptors, omwe samamvetsetsa bwino. Viibryd amagawidwa mwalamulo ngati SSRI ndi 5-HT1A pang'ono agonist. Trintellix amadziwika kuti SSRI ndipo amachita ngati wotsutsana, agonist, komanso agonist pang'ono wama serotonin receptors. Chifukwa cha ntchito yawo, amadziwikanso kuti atypical antidepressants. Mankhwala ena opatsirana pogonana ndi awa:
- Bupropion (Wellbutrin SR, Wellbutrin XL)
- Mirtazapine (Chikumbutso)
- Zamgululi
Gulu lina lofananira (koma losafanana) la mankhwala oponderezana ndi gulu la SNRI, lomwe limayimira serotonin-norepinephrine reuptake inhibitors. Kalasiyi imaphatikizapo mankhwala monga Cymbalta (duloxetine), Effexor (venlafaxine), Pristiq (desvenlafaxine), ndi Fetzima (levomilnacipran).
Kodi Trintellix kapena Viibryd ndibwino?
Ngakhale mankhwala onsewa adavomerezedwa kutengera kafukufuku woyesedwa ndi placebo, kafukufuku sanayerekezere mankhwalawo molunjika. Kuwunikiranso kwakukulu kwamaphunziro ambiri (onani pamwambapa) kunapeza Trintellix kuti ndi imodzi mwazomwe zimalepheretsa kupsinjika mtima. Komabe, mankhwala abwino kwambiri kwa inu angadziwike ndi dokotala wanu, yemwe angayang'ane chithunzi chonse cha matenda anu komanso mbiri yanu ndi mankhwala ena omwe mumamwa.
Kodi nditha kugwiritsa ntchito Trintellix kapena Viibryd ndili ndi pakati?
Funsani wothandizira zaumoyo wanu kwa upangiri wa zamankhwala. Adzafufuza zaubwino wotenga mankhwala opatsirana pogonana motsutsana ndi chiopsezo cha mwanayo. Ma Neonates omwe amapezeka ndi mankhwala opatsirana pogonana, kuphatikiza ma SSRIs, mu trimester yachitatu ya mimba, adakumana ndi zovuta zazikulu.
Ngati muli pa Trintellix kapena Viibryd ndipo mukudziwa kuti muli ndi pakati, funsani OB-GYN anu nthawi yomweyo kuti akuthandizeni. Ngati muli kuyamwitsa , Funsani OB-GYN wanu.
Kodi ndingagwiritse ntchito Trintellix kapena Viibryd ndi mowa?
Ayi. Trintellix kapena Viibryd sayenera kumwedwa ndi mowa chifukwa kuphatikiza kumatha kuwonjezera chiopsezo cha kupuma (kupumira pang'ono, kusapeza mpweya wokwanira) ndikuwonjezera kutopa ndi kugona, komanso kusokoneza chidwi. Kuphatikizaku kungapangitsenso nkhawa ndi kukhumudwa.
Kodi Viibryd amathandizira nkhawa?
Ngakhale Viibryd sivomerezeka kuthana ndi nkhawa, kafukufuku wasonyeza kuti itha kuthandizira kuthana ndi vuto la nkhawa. Chifukwa chake, a Viibryd nthawi zina amatha kulembedwa kuti azichotsa nkhawa.
Kodi Viibryd ndi ya bipolar?
Viibryd sichisonyezedwa kuti imachiza matenda ochititsa munthu kusinthasintha zochitika. Zimangowonetsedwa kuti zigwiritsidwe ntchito pakukhumudwa. Odwala ayenera kuwunikidwa ngati ali ndi vuto la kusinthasintha kwamaganizidwe asanatenge Viibryd. Pulogalamu ya kupereka chidziwitso a Viibryd akuti mwa odwala omwe ali ndi vuto losinthasintha zochitika, kugwiritsa ntchito Viibryd kapena mankhwala ena opewetsa kupsinjika kuti athetse vuto lokhumudwitsa kumatha kuyambitsa gawo losakanikirana.
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